UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No.   )

Filed by the Registrant ☒
Filed by a Party other than the Registrant ☐
Check the appropriate box:

Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under §240.14a-12
IRONWOOD PHARMACEUTICALS, INC.
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check all boxes that apply):

No fee required.

Fee paid previously with preliminary materials

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

[MISSING IMAGE: cov_ofc-4c.jpg]
Filed by the Registrant ý

Filed by a Party other than the Registrant o

Check the appropriate box:

o


Preliminary Proxy Statement

o


Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

ý


Definitive Proxy Statement

o


Definitive Additional Materials

o


Soliciting Material under §240.14a-12



IRONWOOD PHARMACEUTICALS, INC.

(Name of Registrant as Specified In Its Charter)


(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

ý


No fee required.

o


Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
(1)Title of each class of securities to which transaction applies:
(2)Aggregate number of securities to which transaction applies:
(3)Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):
(4)Proposed maximum aggregate value of transaction:
(5)Total fee paid:

o


Fee paid previously with preliminary materials.

o


Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.



(1)


Amount Previously Paid:
(2)Form, Schedule or Registration Statement No.:
(3)Filing Party:
(4)Date Filed:
[MISSING IMAGE: lg_ironwood-bw.jpg]

GRAPHIC


GRAPHIC


Table of Contents

GRAPHIC


100 Summer Street, Suite 2300

Boston, Massachusetts 02110


NOTICE OF 20212024 ANNUAL MEETING OF STOCKHOLDERS OF

IRONWOOD PHARMACEUTICALS, INC.

Date:Tuesday, June 18, 2024
Date:Time:Wednesday, June 2, 2021
Time:9:00 a.m. Eastern Time
Location:Location:
Our 20212024 annual meeting of stockholders will be a "virtual“virtual meeting." You will be able to attend the annual meeting, vote and submit questions via live webcast by visiting www.virtualshareholdermeeting.com/IRWD2021IRWD2024.
Purpose:Purpose:We are holding the annual meeting for stockholders to consider three company sponsored proposals:
1.
1.
To elect our Class I directors,nine director nominees, Mark G. Currie, Ph.D., Alexander J. Denner, Ph.D. and, Andrew Dreyfus, Jon R. Duane, and our Class II directors, Marla L. Kessler, Thomas McCourt, Julie McHugh, Catherine Moukheibir Lawrence S. Olanoff, M.D., Ph.D. and Jay P. Shepard, each to serve for a one-year term;
term extending until our 2025 annual meeting of stockholders and their successors are duly elected and qualified;
2.

To hold an advisory vote on named executive officer compensation; and
3.

To ratify our audit committee'scommittee’s selection of Ernst & Young LLP as our auditors for 2021.2024.

We will also consider action on any other matter that may be properly brought before the meeting or any postponement(s) or adjournment(s) thereof.

Our board of directors recommends you vote "for"“for” each of the nine nominees for Class I and Class II director (proposal no. 1), "for"“for” the advisory vote on named executive officer compensation (proposal no. 2), and "for"“for” ratification of our selection of auditors (proposal no. 3). Only stockholders of record at the close of business on April 12, 202119, 2024 are entitled to notice of and to vote at the meeting.

We are pleased to take advantage of the Securities and Exchange Commission, or SEC, rules that allow us to furnish proxy materials to our stockholders on the internet. We believe these rules allow us to provide you with the information that you need while lowering the costs of delivery and reducing the environmental impact of the annual meeting.

The safety of our stockholders is important to us and given the current guidance by public health officials and protocols that federal, state and local health authorities have imposed surrounding the coronavirus (COVID-19) pandemic, at the time of this filing we believe it is not advisable to hold our

Our annual meeting, as in person.prior years, will be conducted in a virtual-only format, solely by means of a live audio webcast. Our virtual stockholder format uses technology designed to provide our stockholders rights and opportunities to participate in the virtual meeting similar to an in-person meeting. A virtual meeting allows more stockholders to attend the meeting without cost from anywhere around the globe. You may attend the meeting, vote and submit questions electronically during the meeting via live webcast by visiting the website provided above. A list of stockholders of record will be available electronically during the meeting. The website can be accessed on a computer, tablet, or phone with internet connection. To be admitted to the meeting at www.virtualshareholdermeeting.com/IRWD2021IRWD2024, you must enter the 16-digit control number found on your proxy card, voting instruction form or notice that you received.

Proxy Material Mailing Date:
April 25, 2024
Sincerely,
[MISSING IMAGE: sg_thomasmccourt-bw.jpg]
Thomas McCourt
Chief Executive Officer and Director


Proxy Material Mailing Date:
April 22, 2021


Sincerely,
GRAPHIC

Thomas McCourt
President and Interim Chief Executive Officer

GRAPHIC [MISSING IMAGE: htr_bluegreen-4c.jpg]
Table of Contents

GRAPHIC

[MISSING IMAGE: ph_ironwood-4c.jpg]
Letter From Our President and Interim CEO1

About Ironwood



3


Our Board of Directors



5

1

Proposal No. 1 Election of Directors



27About Ironwood

3

Our Executives



28Our Board of Directors

8

Executive Compensation



28
Our Executives30

Executive Compensation33

31
33

Compensation Tables


51
54

CEO Pay Ratio
64
Pay Versus Performance65



67

72

Our Stockholders



68

74

Certain Relationships and Related Person Transactions



71

77



75


User's Guide



76

78

User’s Guide
80
Stockholder Communications, Proposals and Nominations for Directorships


80

84

SEC Filings



81

85

2021  Proxy Statement    i


Table of Contents

GRAPHIC
i   Ironwood

[MISSING IMAGE: htr_greenorange-4c.jpg]
Letter From Our President
and Interim CEO

PHOTO

[MISSING IMAGE: ph_thomasmccourtbg-4c.jpg]

Dear Ironwood stockholders,

Our team showed passion and commitment in 2020 as we continued

I am pleased to executeshare our progress towards realizing our vision of becoming the leading GI healthcare company. At Ironwood, our mission despite the challenges brought on by the COVID-19 pandemic. Ironwood's business fundamentals and financials are strong and we believe the strength of LINZESS® (linaclotide), combined with continued profit and cash generation in 2020, provide a solid foundation for our future.

We have a significant opportunity to execute on our vision to become the leading U.S. gastrointestinal, or GI, healthcare company, advancing treatments for GI diseases and redefining the standard of care for GI patients. Our strategy to get there is grounded on three priorities: maximizing LINZESS, building an innovative GI pipeline, and delivering sustained profits and generating cash flow.

We are Executing Our GI-Focused Strategy

LINZESS showed remarkable resilience in 2020, delivering $931 million in 2020 U.S. net sales—an increase of 10% year-over-year—further strengthening its position as the number one prescribed medicine in the U.S. for the treatment of adults with irritable bowel syndrome with constipation, or IBS-C, or chronic idiopathic constipation, or CIC. We believe there is substantial opportunity for continued growth and are working closely with our partner, AbbVie Inc., or AbbVie, to advance innovative commercial strategies and enhance linaclotide's clinical utility through lifecycle management.

We are also seeking to build an innovative development portfolio by advancing our own IW-3300 for the potential treatment of visceral pain conditions and by pursuing assets that target serious, organic GI diseases. We had some disappointing outcomes from our GI development pipeline last year, and while these types of outcomes are not uncommon in drug development, they are never easy when there are so many patients in need of new therapies. However, with continued scientific progress and our unique expertise and capabilities within GI, we remain committed in our pursuit of innovative treatments for GI diseases.

And lastly, we are continuing our disciplined approach to capital allocation to support our goal of delivering sustainable profits and cash flow. We achieved our second full year of profits in 2020, recording $106 million in net income. Importantly, we ended 2020 with $363 million in cash and cash equivalents—more than doubling our cash position from the end of 2019.

We are Committed to Fostering an Inclusive and Diverse Culture

We believe that creating an equitable, inclusive and diverse culture is critical to attracting, motivating, and retaining the talent necessary to deliver on our mission. In 2020, we adopted a long-term equality, diversity and inclusion strategy, introduced new learning and development opportunities, strengthened our talent acquisition strategies, and made contributions to organizations that advance racial equality and social justice in our communities.

2021  Proxy Statement    1


Table of Contents

GRAPHIC

We are Focused on Driving Stockholder Value

We remain focused on driving value for our stockholders by bringing important medicines to patients and building a growing and successful business. This is central to successfully executing against our strategic priorities and a critical threshold as we continue to invest thoughtfully into our business. Thank you for supporting Ironwood and our path forward. I am confident that with continued focus and execution, Ironwood is well positioned to deliver benefits for patients and value for stockholders.

Sincerely,

GRAPHIC

Thomas McCourt
President and Interim Chief Executive Officer

2    Ironwood


Table of Contents

GRAPHIC
About Ironwood

We aspire to bring innovative treatments for GI diseases to patients in need.

We are a GI healthcare company on a mission to advance the treatment of GI diseases and redefine the standard of care for GI patients. LeveragingThis guiding mission drives us to deliver game-changing GI treatments to patients in need and to do good in the communities in which we and our demonstrated expertisestakeholders live and capabilitieswork.

To uphold these commitments, we remain anchored by our three clearly defined objectives: 1) maximize LINZESS, 2) advance our GI pipeline, and 3) deliver sustained profits and cash flows.
Our blockbuster product, LINZESS, in its 11th year on the market, had a successful 2023, with U.S. net sales increasing by 7% compared to the prior year, driven by continued robust prescription demand growth of 10% year-over-year. Notably, new-to-brand prescriptions saw a significant ramp-up, increasing by 15% compared to 2022, which we believe is a key indicator of future growth potential of LINZESS. LINZESS reached an all-time high of 46% in total prescriptions (TRx) share in the combined branded and generic IBS-C and CIC market, further solidifying its leadership position.
In June 2023, LINZESS received U.S. FDA approval to become the first and only approved prescription therapy for patients ages 6 to 17 years old with functional constipation, providing an important opportunity to expand its clinical utility in younger populations.
Furthermore, in 2023, we strengthened our GI pipeline with the acquisition of VectivBio, a global clinical-stage biopharmaceutical company with operations in Basel, Switzerland. We strongly believe that the VectivBio acquisition fits squarely within our strategic framework and represents a critical step forward for Ironwood to achieve our vision and deliver value for patients and shareholders. Through this acquisition, we are advancing apraglutide, a next-generation, synthetic peptide analog of GLP-2 being evaluated for the treatment of SBS-IF. In February 2024, we announced positive topline results from our STARS Phase III clinical trial in patients with SBS-IF and plan to submit a new drug application and other regulatory filings for apraglutide as a once-weekly GLP-2 analog for use in adult patients with SBS who are dependent on parenteral support. In addition, in late March 2024, we announced positive primary results for our Phase II exploratory trial, STARGAZE, in patients with aGvHD.
Additionally, we are progressing phase 2 studies for CNP-104, a potentially disease-modifying therapy for the treatment of primary biliary cholangitis (PBC), and IW-3300, a GC-C agonist, for the potential treatment of visceral pain conditions, including interstitial cystitis/bladder pain syndrome and endometriosis.
We believe these programs have the potential to improve the standard of care and significantly enhance the quality of life for patients suffering with GI diseases.
We remain focused on making Ironwood a great place to work. We are pleased that our investments in employee programs continue to be reflected in high employee engagement scores and a fourth-consecutive Top Workplaces USA award this year. We were also named a DE&I Standout by The Boston Globe Magazine. We continue strengthening our collaborative culture, advancing our DE&I initiatives through our employee resource groups, and fostering leadership and talent development.

2024 Proxy Statement   1

[MISSING IMAGE: hr_greenltsm-4c.jpg]
I encourage you to read the following pages, which will tell you more about our journey as a company and my confidence that Ironwood is well positioned for future growth. This confidence is underscored by our legacy of innovation and leadership in GI, the expected durability of LINZESS, our enriched R&D pipeline, and our ability to responsibly generate shareholder value.
We are grateful to our colleagues, clinical investigators, physicians, partners, and, of course, patients and their families who have made our advancements possible, and we look forward to continued progress and momentum across our R&D programs and corporate objectives in the year ahead.
Thank you for your continued support and investment in our important work.
Sincerely,
[MISSING IMAGE: sg_thomasmccourt-bw.jpg]
Thomas McCourt
Chief Executive Officer and Director

2   Ironwood

[MISSING IMAGE: htr_greenorange-4c.jpg]
About Ironwood
We aspire to bring innovative treatments for GI diseases weto patients in need.
We are a gastrointestinal, or GI, healthcare company dedicated to advancing the treatment of GI diseases and redefining the standard of care for GI patients. We are focused on the development and commercialization of innovative GI product opportunities in areas of significant unmet need.

LINZESS®need, leveraging our demonstrated expertise and capabilities in GI diseases.

LINZESS® (linaclotide), our commercial product, is the first product approved by the United States Food and Drug Administration, or U.S. FDA, in a class of GI medicines called guanylate cyclase type C agonists, or GC-C agonists, and is indicated for adult men and womenadults suffering from irritable bowel syndrome with constipation, or IBS-C, or CIC.chronic idiopathic constipation, or CIC, and for pediatric patients ages 6-17 years-old with functional constipation, or FC. LINZESS is the U.S. branded prescription market leader for adults in the IBS-C and CIC category in the U.S. Outside of the U.S.,categories. LINZESS is available to adults suffering from IBS-C or CIC in the United States, Mexico and Japan andSaudi Arabia, to adults suffering from IBS-C or chronic constipation in Japan, IBS-C in China (including Hong Kong and Macau).for pediatric patients ages 6-17 years-old with FC in the U.S. Linaclotide is also available under the trademarked name CONSTELLA®CONSTELLA® to adults suffering from IBS-C or CIC in Canada, and to adults suffering from IBS-C in certain European countries.

In addition to LINZESS, we have an emerging pipeline of innovative GI assets, highlighted by apraglutide for the potential treatment of short bowel syndrome with intestinal failure, or SBS-IF, a severe malabsorptive condition. We believe apraglutide has the potential to improve the standard of care for all adult patients with SBS who are dependent on parenteral support, or PS, as the only synthetic peptide analog of glucagon-like peptide-2, or GLP-2, with once‑weekly administration, and extend the growth horizon of our company through the 2030s if successfully developed, approved and commercialized.
Additionally, we recently announced positive primary results for our Phase II exploratory trial, STARGAZE, in patients with aGvHD, and are progressing with Phase II studies for CNP-104, a potentially disease-modifying therapy for the treatment of primary biliary cholangitis, or PBC, and phase 2 proof of concept study for IW-3300, a guanylate cyclase-C, or GC-C, agonist, for the potential treatment of visceral pain conditions, including interstitial cystitis/bladder pain syndrome, or IC/BPS, and endometriosis.
We recognize the value of collaboration and have a track record of establishing, operating and evolving high-performance partnerships globally. We have strategic partnerships with leading pharmaceutical companies to support the development and commercialization of linaclotide around the world. We also aim to leverage our leading capabilities in GI to bring additional treatment options to GI patients in the U.S.

patients.

We believe our history of innovation in GI medicine, deep expertise in developing and commercializing innovative GI therapies, established relationships within the GI community, as well as our leadership'sleadership’s experience building blockbuster brands, positions us well to advance GI care and bring treatments that canwith the potential to deliver great impact for patients, our business and our stockholders.

Our

In 2023, our GI-focused strategy, in 2020 was focusedbuilding on our commercial success and GI development capabilities, continued to center on three core priorities: drivemaximize LINZESS, growth, advance our GI development portfoliopipeline, and deliver sustainable profits. Our performance against our 2020 core priorities was as follows:

sustained profits and cash flow.

2024 Proxy Statement   3

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Performance Against 2023 Core Priorities
1.
Drive
Maximize LINZESS Growth


We grew our share ofrecognized $430.5 million in collaborative arrangements revenue related to sales of LINZESS in the U.S. by 13% year-over-year to $369 million forduring the year ended December 31, 2020. This2023, an increase of $31.7 million compared to the year ended December 31, 2022. The increase was primarily driven by a 9%10% increase in LINZESS prescription demand, partially offset by inventory channel fluctuations. We remain confident in the U.S. in 2020 compared to 2019.

long-term growth potential of LINZESS based on continued strong prescription demand.
The
In June 2023, the U.S. FDA approved LINZESS as a supplemental New Drug Application,once-daily treatment for pediatric patients ages 6-17 years-old with FC, making LINZESS the first and only FDA-approved prescription therapy for FC in this patient population. The safety and effectiveness of LINZESS in patients with FC less than 6 years of age or NDA,in patients with IBS-C less than 18 years of age have not been established. Additional clinical pediatric programs in IBS-C and FC are ongoing.
2.
Advance our GI Pipeline

In June 2023, we completed a tender offer to purchase 98% of the outstanding ordinary shares of VectivBio Holding AG, or VectivBio, a clinical-stage biotechnology company focused on the discovery and development of treatments for LINZESS, resultingsevere, rare GI conditions for which there is a significant unmet medical need. In December 2023, we completed a squeeze-out merger to acquire all remaining shares. The VectivBio acquisition was partially funded with $400 million of borrowings under a new revolving credit facility. Through the acquisition, we are advancing apraglutide, a next-generation, synthetic peptide analog of GLP-2 for rare gastrointestinal diseases, including SBS-IF.

In February 2024, we announced positive topline results from the pivotal Phase III STARS trial, which evaluated the efficacy and safety of once-weekly subcutaneous apraglutide in updated U.S. prescribing information with data demonstrating that linaclotide improved the overall abdominal symptoms of bloating, discomfort, and painreducing PS dependency in adult patients with IBS-C comparedSBS-IF. SBS-IF, a rare and severe organ failure condition in which patients are dependent on PS, affects an estimated 18,000 adult patients in the U.S., Europe and Japan. Based on the results from the STARS trial, we plan to placebo.

Wesubmit a new drug application and our U.S. partner, AbbVie, entered into settlement agreements with the two remaining generic drug manufacturers resolving all pending patent infringement litigation brought in response to abbreviated New Drug Applications, or NDAs, seeking approval to market generic versions of LINZESS prior to the expiration of our and AbbVie's applicable patents.

The United States Patent and Trademark Office granted patents covering the formulation of the 72 mcg dose of LINZESS and methods of using the formulation. The patents are expected to expire in 2031.

2021  Proxy Statement    3


Table of Contents

GRAPHIC
2.
Advance U.S. GI Development Portfolio

MD-7246:  We and AbbVie announced top-line data from a Phase II trial evaluating MD-7246, a delayed release formulation of linaclotide,other regulatory filings for apraglutide for use in adult patients with abdominal pain associated with irritable bowel syndrome with diarrhea, or IBS-D. TheSBS who are dependent on PS.

In March 2024, we announced positive, primary results up to Day 91 for our Phase II exploratory trial, did not meet its primarySTARGAZE, to evaluate apraglutide in patients with steroid-refractory gastrointestinal acute Graft versus Host Disease, or key secondary endpoints. Based on these findings,aGvHD, which evaluated the safety and tolerability of once-weekly apraglutide in aGvHD patients treated with standard of care, including systemic corticosteroids and ruxolitinib.

Through our collaboration and license option agreement, or the COUR Collaboration Agreement, with COUR Pharmaceutical Development Company, Inc., a biotechnology company developing novel immune-modifying nanoparticles to treat autoimmune diseases, or COUR, we and AbbVie madeCOUR are developing CNP-104 for the quick, data-driven decisionpotential treatment of PBC, a rare autoimmune disease targeting the liver that affects approximately 130,000 people in the U.S., according to discontinuea study published in Clinical Gastroenterology and Hepatology in 2018. If successful, CNP-104 has the potential to be the first approved disease-modifying therapy for PBC. COUR is currently conducting a clinical study to evaluate the safety, tolerability, pharmacodynamic effects and efficacy of CNP-104 in PBC patients, with topline data expected in the third quarter of 2024.

We are advancing IW-3300, a GC-C agonist, for the potential treatment of visceral pain conditions, including IC/ BPS and endometriosis. IC/BPS affects an estimated 4 to 12 million people in the U.S., according to the Interstitial Cystitis Association as of 2022. An estimated 4 million reproductive-age women in the U.S. have been diagnosed with endometriosis, according to a study published in Gynecologic and Obstetric Investigation in 2017. Both diseases have a limited number of treatment options available. We successfully completed Phase I

4   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
studies to evaluate the safety and tolerability of IW-3300 in healthy volunteers and are continuing the Phase II proof of concept study in IC/BPS.
3.
Deliver Sustained Profits and Cash Flow

In 2023, we recognized a net loss of approximately $1.0 billion, which included a non-recurring charge of approximately $1.1 billion for acquired in-process research and development of MD-7246.

IW-3718:  We announced that one of our two identical Phase III trials evaluating IW-3718, a gastric retentive formulation of a bile acid sequestrant, in refractory gastroesophageal reflux disease, or refractory GERD, did not meetconnection with the pre-specified criteria associated with a planned early efficacy assessment. Following the assessment from an independent data monitoring committee, we unblinded the data and confirmed that the data from this Phase III trial did not meet the criteria, including the study's primary endpoint of achieving a statistically significant improvement in heartburn severity. Based on these findings, we made the quick, data-drive decision to discontinue the development of IW-3718.

VectivBio acquisition.
We expanded our strategy to build our GI portfolio to include external commercial and earlier-stage clinical assets focused on serious, organic GI diseases.

3.
Deliver Sustainable Profits

We delivered net income of $106 million during the year ended December 31, 2020, reflecting our second consecutive full year of profitability.


We generated $169$183.4 million in cash from operations during the year ended December 31, 2020,2023, ending the year with $363$92.2 million in cash and cash equivalents. On December 31, 2019,
As we had $177 millioncontinue to execute on our strategic priorities, we have great confidence in cashour ability to continue making a meaningful difference for GI patients and cash equivalents.

We demonstrated strong progress acrossrealize our corporate goalsvision of becoming the leading GI healthcare company in 2020. As a result, our 2020the industry.

Our 2023 company performance achievement multiplier, which we used as a key consideration in determining executive compensation for 20202023 performance, was 101%120%, as determined by our board of directors. Please see the Compensation Discussion and Analysis section included elsewhere in this proxy statement for detailed information on compensation to our 20202023 named executive officers.


2024 Proxy Statement   5

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Note about Forward-Looking Statements
This proxy statement contains forward-looking statements. Investors are cautioned not to place undue reliance on these forward-looking statements, including statements about Ironwood’s ability to execute on its mission; Ironwood’s strategy, business and operations; Ironwood’s ability to drive growth and generate shareholder value; the commercial potential of LINZESS; the potential of apraglutide to improve the standard of care for all adult patients with SBS dependent on parenteral support; the potential of CNP-104 to be the first approved disease-modifying therapy for PBC; the potential of apraglutide and CNP-104 to extend the growth horizon of Ironwood through the 2030s; Ironwood’s plan to submit a new drug application and other regulatory filings for apraglutide for use in adult patients with SBS who are dependent on PS; Ironwood’s anticipation of reaching new clinical development milestones in 2024 and the timing of data related thereto, and the belief that Ironwood is positioned well for long term growth. These forward-looking statements speak only as of the date of this proxy statement, and Ironwood undertakes no obligation to update these forward-looking statements. Each forward-looking statement is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statement. Applicable risks and uncertainties include those related to the effectiveness of development and commercialization efforts by us and our partners; preclinical and clinical development, manufacturing and formulation development of linaclotide, apraglutide, CNP-104, IW-3300, and our product candidates; the risk of uncertainty relating to pricing and reimbursement policies in the U.S., which, if not favorable for our products, could hinder or prevent our products’ commercial success; the risk that clinical programs and studies, including for apraglutide, IW-3300 and CNP-104, may not progress or develop as anticipated, including that studies are delayed or discontinued for any reason, such as safety, tolerability, enrollment, manufacturing, economic or other reasons; the risk that findings from our completed nonclinical and clinical studies may not be replicated in later studies; the risk of competition or that new products may emerge that provide different or better alternatives for treatment of the conditions that our products are approved to treat; the risk that we are unable to execute on our strategy to in-license externally developed products or product candidates; the risk that we are unable to successfully partner with other companies to develop and commercialize products or product candidates; the risk that healthcare reform and other governmental and private payor initiatives may have an adverse effect upon or prevent our products’ or product candidates’ commercial success; the efficacy, safety and tolerability of linaclotide and our product candidates; the risk that the commercial and therapeutic opportunities for LINZESS or our product candidates are not as we expect; decisions by regulatory and judicial authorities; the risk we may never get additional patent protection for linaclotide and other product candidates, that patents for linaclotide or other products may not provide adequate protection from competition, or that we are not able to successfully protect such patents; the risk that we are unable to manage our expenses or cash use, or are unable to commercialize our products as expected; we may elect to not exercise our option to acquire the exclusive license for CNP-104; the risk that the development of any of our linaclotide pediatric programs, apraglutide, CNP-104 and/or IW-3300 are not successful or that any of our product candidates does not receive regulatory approval or is not successfully commercialized; outcomes in legal proceedings to protect or enforce the patents relating to our products and product candidates, including abbreviated new drug application litigation; the risk that financial and operating results may differ from our projections; developments in the intellectual property landscape; challenges from and rights of competitors or potential competitors; the risk that our planned investments do not have the anticipated effect on our company revenues; developments in accounting guidance or practice; Ironwood’s or AbbVie’s accounting practices, including reporting and settlement practices as between Ironwood and AbbVie; the risk that we are unable to manage our expenses or cash use, or are unable to commercialize our products as expected; the risk that our indebtedness could adversely affect our financial condition or restrict our future operations; and the risks listed under the heading “Risk Factors” and elsewhere in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, and in our subsequent SEC filings.

6   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Note regarding Trademarks
In this proxy statement, references to "the company"“the company” or "Ironwood"“Ironwood” and, except within the Audit Committee Report and the Compensation Committee Report, references to "we"“we”, "us"“us” or "our"“our” mean Ironwood Pharmaceuticals, Inc. LINZESS®LINZESS® and CONSTELLA®CONSTELLA® are trademarks of Ironwood Pharmaceuticals, Inc. Any other trademarks referred to in this proxy statement are the property of their respective owners. All rights reserved. The contents of our website are not incorporated into this document and you should not consider information provided on our website to be part of this document.

4    Ironwood


Table of Contents

GRAPHIC
2024 Proxy Statement   7

[MISSING IMAGE: htr_bluegreen-4c.jpg]
Our Board of Directors


Who We Are

The following table sets forth certain information, as of April 22, 2021,25, 2024, with respect to each of our directors:

directors. Each director has been nominated for election at the 2024 annual meeting of stockholders to serve for a one-year term extending until the 2025 annual meeting of stockholders and his or her successor is duly elected and qualified.
[MISSING IMAGE: bc_line-4c.jpg]
NameAgeAudit
Committee
Governance
and Nominating
Committee
Compensation
and HR Committee
Mark Currie, Ph.D.69
Alexander Denner, Ph.D.54C
Andrew Dreyfus65C
Jon Duane65
Marla Kessler54
Thomas McCourt66
Julie McHugh, Chair59
Catherine Moukheibir64C
Jay Shepard66

Name

 Age Class Year Term
Expires
 Audit
Committee
 Governance
and Nominating
Committee
 Compensation
and HR Committee

Mark G. Currie, Ph.D.

 66 I 2021   

Alexander J. Denner, Ph.D.

 51 I 2021     

Jon R. Duane

 62 I 2021    

Marla L. Kessler

 51 II 2021     

Catherine Moukheibir

 61 II 2021 C  

Lawrence S. Olanoff, M.D., Ph.D.

 69 II 2021   C  

Jay P. Shepard

 63 II 2021    

Andrew Dreyfus

 62 III 2022     C

Julie H. McHugh, Chair

 56 III 2022     

Edward P. Owens

 74 III 2022     

"C"“C” indicates chair of the committee.

2021  Proxy Statement    5


Table of Contents

GRAPHIC
8   Ironwood

Class I Directors (nominated for election at the 2021 annual meeting)

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]



MARK G.

CURRIE, Ph.D.

Former President and Chief
Scientific Officer, Cyclerion
Therapeutics, Inc.

Partner, Iaso Ventures, LP
Age: 66

69

Director since 2019

Board Committees

Compensation and HR Committee


Dr. Currie has served asbeen a senior advisor topartner of Iaso Ventures, LP, an early-stage healthcare venture capital firm, since January 2024. Dr. Currie was previously the chair of the scientific advisory board of Cyclerion Therapeutics, Inc., or Cyclerion, a clinical-stage biopharmaceutical company, sincefrom January 2021.2021 to September 2023. Prior to that, Dr. Currie previously served as Cyclerion'sCyclerion’s president and chief scientific officer from April 2019 to December 2020, and, prior2020. Prior to that,joining Cyclerion, Dr. Currie served as senior vice president, chief scientific officer and president of research and development at Ironwood from 2002 to April 2019.


Prior to joining Ironwood, Dr. Currie directed cardiovascular and central nervous system disease research as vice president of discovery research at Sepracor, Inc. and initiated, built and led discovery pharmacology and also served as director of arthritis and inflammation at Monsanto Company.


Dr. Currie currently serves on the board of directors of Antag Therapeutics ApS, Science Exchange, LLC.

Inc. and Sea Pharmaceuticals, LLC, each of which is a privately held company. Dr. Currie also chairs the scientific advisory boards of Wild Bioscience Ltd. and Tisento Therapeutics, Inc.


Dr. Currie earned a B.S. in biology from the University of South Alabama and holds a Ph.D. in cell biology from the Bowman Gray School of Medicine of Wake Forest University.


We believe that Dr. Currie'sCurrie’s vast experience leading the research and development efforts of an international biotechnology company will prove instrumental in guiding us through the research and development of novel therapies.





ALEXANDER J.
DENNER, Ph.D.

Founding Partner and
Chief
Investment Officer,
Sarissa
Capital Management LP

Age: 51

54

Director since 2020

Board Committees


Governance and Nominating Committee,

Chair


Dr. Denner is a founding partner and the chief investment officer of Sarissa Capital Management LP, or Sarissa, a registered investment advisor, where he has been since 2011.


Prior to joining Sarissa, Dr. Denner served as a senior managing director at Icahn Capital L.P,LP, an investment advisory firm, from 2006 to 2011. Prior to that, he served as a portfolio manager at Viking Global Investors, a private investment fund, and Morgan Stanley Investment Management, a global asset management firm.


Dr. Denner serves on the board of directors of BiogenAttralus, Inc., a privately held company. In the last five years, Dr. Denner has served as chair of the board of directors of Ariad Pharmaceuticals, Inc. and The Medicines Company and Sarissa Capital Acquisition Corp., as well as a member of the board of directors of BioverativBiogen Inc.


Dr. Denner earned his B.S. in mechanical engineering from Massachusetts Institute of Technology, an M.S. and M.PhilM.Phil. in mechanical engineering from Yale University and an interdisciplinary Ph.D. from Yale University.


Dr. Denner brings to the board significant experience overseeing the operations and research and development of healthcare companies and evaluating corporate governance matters. He also has extensive experience as an investor, particularly with respect to healthcare companies, and possesses broad healthcare industry knowledge.

6    Ironwood


Table of Contents

GRAPHIC
2024 Proxy Statement   9

[MISSING IMAGE: hr_greenltsm-4c.jpg]

ANDREW
DREYFUS
Former President and Chief
Executive Officer for Blue Cross
Blue Shield of Massachusetts
Age: 65
Director since 2016
Board Committees

Compensation and HR Committee, Chair



Mr. Dreyfus most recently served as president and chief executive officer for Blue Cross Blue Shield of Massachusetts, or BCBSMA, one of the largest Blue Cross Blue Shield insurance plans in the country, from 2010 to 2022. From 2005 to 2010, Mr. Dreyfus served as the executive vice president of healthcare services of BCBSMA.

Prior to joining BCBSMA, he served as the first president of the Blue Cross Blue Shield Foundation. Mr. Dreyfus also previously served as executive vice president of the Massachusetts Hospital Association and held a number of senior positions in Massachusetts state government, including undersecretary of consumer affairs and business regulation.

Mr. Dreyfus serves on the board of directors and as a member of the audit committee and the compensation and management development committee of Alto Neuroscience, Inc. (NYSE: ANRO), a public company. Mr. Dreyfus also serves on the board of directors of Octave Health Group Inc., a privately held companyand the Joint Commission, the National Quality Forum and BCBSMA Foundation, all of which are non-profit organizations. He is a member of the advisory boards of Ariadne Labs, Vanna Health and the Massachusetts Coalition for Serious Illness Care. He previously served on the board of directors for BCBSMA, the Blue Cross Blue Shield Association and RIZE Massachusetts.

Mr. Dreyfus received a B.A. in English from Connecticut College.

Mr. Dreyfus brings to our board of directors significant expertise in the healthcare payer and reimbursement market, and broad management and executive leadership experience, providing valuable insight as we continue to develop and commercialize medicines in an evolving healthcare landscape.
JON R.

DUANE

Senior Partner Emeritus,

McKinsey & Company

Age: 62

65

Director since 2019

Board Committees


Governance and Nominating Committee


Compensation and HR Committee


Mr. Duane is senior partner emeritus at McKinsey & Company, or McKinsey, an international management consulting company. Before his retirement in December 2017, Mr. Duane had served as a partner at McKinsey since 1992.


At McKinsey, Mr. Duane founded and led the firm'sfirm’s biotech practice. In that role, Mr. Duane advised both private and public companies in the pharmaceutical, medical device and life science industries, as well as academic research centers, on various strategic initiatives.


Mr. Duane serves as the executive chair on the board of directors of Nashville Biosciences.

Biosciences, LLC, a privately held company.


Mr. Duane graduated from Wesleyan University with a B.A. in government and received an M.B.A from Harvard Business School.


Mr. Duane brings to the board of directors significant experience advising academic research centers and companies across the life science and medical device industries.

2021  Proxy Statement    7


Table of Contents

GRAPHIC
10   Ironwood

Class II Directors (nominated for election at the 2021 annual meeting)

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]



MARLA L.

KESSLER

Former Senior Vice President
for Strategy,Chief Marketing and
Communications, IQVIA
HoldingsOfficer, Datavant, Inc.

Age: 51

54

Director since 2019

Board Committees


Compensation and HR Committee


Ms. Kessler most recently served as chief marketing officer of Datavant, Inc., or Datavant, a health IT company, from October 2022 to April 2024. Prior to joining Datavant, Ms. Kessler served as chief customer officer of Aetion, Inc., or Aetion, a health care technology company, from September 2021 to October 2022, and prior that, as an advisor to the chief executive officer of IQVIA Holdings Inc., or IQVIA (formerly IMS Health and Quintiles), a global analytics and technology company, from October 2020 to February 2021. Prior to that, Ms. Kessler had been the senior vice president for strategy, marketing and communications for IQVIA since October 2016.


Previously, Ms. Kessler served in various roles for IQVIA, including vice president for global services marketing and knowledge management from 2013 to September 2016, regional leader of the IMS Consulting Group in Europe from 2011 to 2013, location manager for the London IMS Consulting Group from 2009 to 2011 and senior principal from 2008 to 2009.


Before joining IQVIA, Ms. Kessler led several marketing efforts for Pfizer Inc. from 2004 to 2007 and worked in consulting for McKinsey & Company from 1996 to 2004.


Ms. Kessler received a B.S. in economics from Arizona State University and an M.B.A. from the Fuqua School of Business at Duke University.


Ms. Kessler provides an important commercial perspective to our board of directors given her expertise in strategic marketing, evidence-based research and customer experience in the life science industry.

THOMAS
McCOURT
Chief Executive Officer, Ironwood Pharmaceuticals, Inc.
Age: 66
Director since 2021

Mr. McCourt has served as our chief executive officer and member of the board of directors since June 2021 and had previously served as president and interim chief executive officer from March 2021 to June 2021 and as president from April 2019 to June 2021. Prior to April 2019, Mr. McCourt served as our senior vice president of marketing and sales and chief commercial officer since joining Ironwood in 2009.

Prior to joining Ironwood, Mr. McCourt led the U.S. brand team for denosumab at Amgen Inc. from 2008 to 2009. Prior to that, Mr. McCourt was with Novartis AG from 2001 to 2008, where he directed the launch and growth of ZELNORM™ for the treatment of patients with IBS-C and CIC and held a number of senior commercial roles, including vice president of strategic marketing and operations.

Mr. McCourt was also part of the founding team at Astra-Merck Inc., leading the development of the medical affairs and science liaison group and then serving as brand manager for PRILOSEC® and NEXIUM®.

Mr. McCourt serves on the board of directors and as a member of the compensation committee of Pliant Therapeutics, Inc. (Nasdaq: PLRX), a public company, and on the board of trustees for the American Society of Gastrointestinal Endoscopy (ASGE). Mr. McCourt previously served on the board of directors of Acceleron Pharma Inc., including as a member of the audit committee and the chair of the nominating and governance committee.

Mr. McCourt received a B.S. in pharmacy from the University of Wisconsin.

Given his role as our chief executive officer and his previous leadership roles at the company since joining in 2009, we believe Mr. McCourt brings unique and in-depth insight into the operations and management of the company, which together with his extensive commercial experience, his deep knowledge of GI, and his experience launching and achieving blockbuster status for LINZESS, are valuable to our board of directors.



2024 Proxy Statement   11

[MISSING IMAGE: hr_greenltsm-4c.jpg]

JULIE
McHUGH, CHAIR
Former Chief Operating Officer, Endo Health Solutions, Inc.
Age: 59
Director since 2014
Board Committees

Audit Committee

Governance and Nominating Committee



Ms. McHugh most recently served as chief operating officer for Endo Health Solutions, Inc., or Endo, from 2010 through 2013, where she was responsible for the specialty pharmaceutical and generic drug businesses.

Prior to joining Endo, Ms. McHugh was the chief executive officer of Nora Therapeutics, Inc.

Before that she served as company group chair for the worldwide virology business unit of Johnson & Johnson, or J&J, and previously she was president of Centocor, Inc., a J&J subsidiary. While at J&J, Ms. McHugh oversaw the development and launches of several products, including Remicade® (infliximab) and she was responsible for oversight of a research and development portfolio including compounds targeting autoimmune diseases, HIV, hepatitis C, and tuberculosis.

Prior to joining Centocor, Inc., Ms. McHugh led marketing communications for gastrointestinal drug Prilosec® (omeprazole) at Astra-Merck Inc.

Ms. McHugh currently serves on the board of directors of Lantheus Holdings, Inc. (Nasdaq: LNTH), a public company, and Xellia Pharmaceuticals ApS, a privately held company. She also serves on the strategic advisory board for HealthCare Royalty Partners and the board of visitors for the Smeal College of Business of Pennsylvania State University. She previously served on the board of directors for Aerie Pharmaceuticals, Inc., Trevena, Inc., ViroPharma Inc., Epirus Biopharmaceuticals, Inc., Evelo Biosciences, Inc., the Biotechnology Industry Organization, the Pennsylvania Biotechnology Association and the New England Healthcare Institute.

Ms. McHugh received her M.B.A. degree from St. Joseph’s University and her B.S. degree from Pennsylvania State University.

Ms. McHugh’s experience as a chief executive officer and a chief operating officer at large multinational pharmaceutical companies makes her a valuable member of our board of directors. Her deep knowledge of Ironwood’s history and strategy and strong relationships with our senior leadership team also make her a valuable resource.
CATHERINE

MOUKHEIBIR

Former Chief Executive Officer,

MedDay Pharmaceuticals

Age: 61

64

Director since 2019

Board Committees


Audit Committee, Chair


Ms. Moukheibir most recently served as chief executive officer of MedDay Pharmaceuticals, or MedDay, a biopharmaceutical company that focused on nervous system disorders, from July 2019 to January 2021. She was also the chairmanchair of the board of directors of MedDay from April 2016 to January 2021.


Prior to that, Ms. Moukheibir served as the senior advisor for finance and a member of the executive board of directors at Innate Pharma SA, an oncology company, from 2011 to December 2016, and as the chief financial officer for Movetis N.V. from 2008 to 2010, when it was acquired.


Ms. Moukheibir previously served as the director of capital markets for Zeltia Group S.A. from 2001 to 2007.


Ms. Moukheibir currently serves on the board of directors of the following public companies: MoonLake Immunotherapeutics AG (Nasdaq: MLTX), Biotalys NV (EBR: BTLS) and chairsOxford Biomedica plc (LSE: OXB)(1). Ms. Moukheibir also serves on the audit committeeboard of Orphazyme A/Sdirectors of Asceneuron SA, Noema Pharma AG and CMR Surgical.Surgical, all of which are privately held companies. She also held past directorships on the boards of directors of Ablynx NV, Cerenis Therapeutics SA, Creabilis S.A., DNA Script SAS, GenKyoTex S.A., Kymab Group Limited, Orphazyme A/S and Zealand Pharma A/S.


Ms. Moukheibir has an M.A. in economics and an M.B.A. from Yale University.


Ms. Moukheibir'sMoukheibir’s long leadership career in the biopharmaceutical industry, as well as her deep background in international finance, provide her with valuable business and financial expertise in support of our corporate objectives.

8    Ironwood


Table

In March 2024, Ms. Moukheibir informed the board of Contents

directors of Oxford Biomedica plc, or Oxford, that she does not intend to stand for re-election at Oxford’s upcoming annual general meeting in June 2024.
GRAPHIC
12   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]



LAWRENCE S. OLANOFF, M.D., Ph.D.

Former Chief Operating Officer, Forest Laboratories, Inc.

Age: 69

Director since 2015

Board Committees

Governance and Nominating Committee, Chair

Dr. Olanoff most recently served as chief operating officer for Forest Laboratories, Inc., or Forest, (acquired by Allergan plc) from 2006 to 2010. Dr. Olanoff also served as a director of Forest from 2006 to 2014.

From 2005 to 2006, Dr. Olanoff was president and chief executive officer and a director at Celsion Corporation. He also served as executive vice president and chief scientific officer of Forest from 1995 to 2005.

Prior to joining Forest in 1995, Dr. Olanoff served as senior vice president of clinical research and development at Sandoz Pharmaceutical Corporation (now a division of the Novartis Group) and at the Upjohn Company in a number of positions, including corporate vice president of clinical development and medical affairs.

In addition, he is currently an adjunct assistant professor and special advisor to the president for corporate relations at the Medical University of South Carolina (MUSC), an ex-officio director of the MUSC Foundation for Research Development, chairman of the board of directors of Mitochondria in Motion, chairman of TAC Development LLC, chairman of the Elliot and Eleanor Foundation and a member of the board of directors of Clinical Biotechnology Research Institute at Roper St. Francis Hospital, the Westedge Project, Ichnos Sciences, and the Zucker Institute for Applied Neurosciences. Dr. Olanoff also held past directorships on the boards of directors of Axovant Sciences Ltd. and Celsion Corporation.

Dr. Olanoff received his Ph.D. in biomedical engineering and M.D. degree from Case Western Reserve University.

Dr. Olanoff's detailed knowledge of the pharmaceutical industry, his broad operational experience and his research and development leadership over the course of his career make him an important asset to our board of directors.





JAY P.

SHEPARD

Former President and Chief

Executive Officer of Aravive, Inc.

Age: 63

66

Director since 2020

Board Committees


Audit Committee


Mr. Shepard is an advisor at Catalyst Pacific, a venture group focused on licensing drug programs and creating new companies in the U.S. and Japan. Mr. Shepard previously was president and chief executive officer of Aravive, Inc. (formerly Versartis, Inc.), a clinical-stage oncology company, from May 2015 to January 2020, and has served as a member of its board of directors sincewhen he retired. From 2013 and asto 2015, Mr. Shepard was executive chairman of its board of directors since January 2020.

Versartis, Inc.


From 20122008 until May 2015, Mr. Shepard was an executive partner at Sofinnova Ventures, a venture capital firm focused on the healthcare industry, which he joined as an executive in residence in 2008.industry. From 2010 to 2012, Mr. Shepard served as president and chief executive officer and was a member of the board of directors of NextWave Pharmaceuticals, Inc., a specialty pediatric pharmaceutical company. From 2005 to 2007, Mr. Shepard served as interim president and chief executive officer of Relypsa (Ilypsa, Inc.’s spin-out company, which was acquired by Galencia), a pharmaceutical company. Mr. Shepard was also vice president of commercial operations at Telik and a memberoncology business unit head of the board of directors of Ilypsa, Inc.Alza Pharmaceuticals (acquired by Amgen Inc.), a biopharmaceutical company focused on therapies for renalJ&J).

Mr. Shepard has over 35 years of experience in the pharmaceutical, biotechnology and metabolic disorders.

drug delivery arenas. Mr. Shepard has participated in or led over 16 product launches by preparing markets and establishing sales and marketing operations.


Mr. Shepard also currently serves on the board of directors of the following public companies: Inovio Pharmaceuticals, Inc., (Nasdaq: INO) and Esperion Therapeutics, Inc. (Nasdaq: ESPR). In addition, Mr. Shepard serves on the board of directors of Aculys Pharma, LLC, Cessation Therapeutics, Inc. and Pathalys Pharma, Inc., each of which is a privately held company. Mr. Shepard also serves as the chairman of the board of directors of the Christopher & Dana Reeve Foundation. Within the past five years, Mr. Shepard also served on the boards of directors of Marinus Pharmaceuticals, Inc. and Durect Corporation.


Mr. Shepard holds a B.S. in Business Administration from the University of Arizona.


Mr. Shepard brings deep expertise to our board of directors, as a recognized leader within the pharmaceutical industry, with nearly three decades of expertise as an accomplished public company CEO and senior executive.

2021


2024 Proxy Statement   9


Table of Contents

GRAPHIC
13

Class III Directors (term expires at the 2022 annual meeting)

[MISSING IMAGE: hr_greenltsm-4c.jpg]



ANDREW
DREYFUS

President and Chief Executive
Officer for Blue Cross Blue
Shield of Massachusetts

Age: 62

Director since 2016

Board Committees

Compensation and HR Committee, Chair

Mr. Dreyfus has served as president and chief executive officer for Blue Cross Blue Shield of Massachusetts, or BCBSMA, one of the largest Blue Cross Blue Shield insurance plans in the country, since 2010. From 2005 to 2010, Mr. Dreyfus served as the executive vice president of healthcare services of BCBSMA.

Prior to joining BCBSMA, he served as the first president of the Blue Cross Blue Shield Foundation. Mr. Dreyfus also previously served as executive vice president of the Massachusetts Hospital Association and held a number of senior positions in Massachusetts state government, including undersecretary of consumer affairs and business regulation.

Mr. Dreyfus serves on the board of directors of BCBSMA, the Blue Cross Blue Shield Association, Boys & Girls Clubs of Boston and RIZE Massachusetts. He is a member of the advisory boards of Ariadne Labs and the Leonard D. Schaeffer Center for Health Policy & Economics at the University of Southern California (USC). He is a founding member of the Massachusetts Coalition for Serious Illness Care.

Mr. Dreyfus received a B.A. in English from Connecticut College.

Mr. Dreyfus brings to our board of directors significant expertise in the healthcare payer and reimbursement market, and broad management and executive leadership experience, providing valuable insight as we continue to develop and commercialize medicines in an evolving healthcare landscape.


How We are Selected and Evaluated



JULIE H.
McHUGH, CHAIR

Former Chief Operating Officer,
Endo Health Solutions, Inc.

Age: 56

Director since 2014

Board Committees

Audit Committee

Governance and Nominating Committee

Ms. McHugh most recently served as chief operating officer for Endo Health Solutions, Inc., or Endo, from 2010 through 2013, where she was responsible for the specialty pharmaceutical and generic drug businesses.

Prior to joining Endo, Ms. McHugh was the chief executive officer of Nora Therapeutics, Inc.

Before that she served as company group chairman for the worldwide virology business unit of Johnson & Johnson, or J&J, and previously she was president of Centocor, Inc., a J&J subsidiary. While at J&J, Ms. McHugh oversaw the development and launches of several products, including Remicade® (infliximab), Prezista® (darunavir) and Intelence® (etravirine), and she was responsible for oversight of a research and development portfolio including compounds targeting HIV, hepatitis C, and tuberculosis.

Prior to joining Centocor, Inc., Ms. McHugh led the marketing communications for gastrointestinal drug Prilosec® (omeprazole) at Astra-Merck Inc.

Ms. McHugh currently serves on the board of directors of Trevena, Inc. (with such service to end in connection with Trevena, Inc.'s 2021 annual meeting of stockholders), Aerie Pharmaceuticals, Inc. and Lantheus Holdings, Inc. She also serves on the board of directors of Evelo Biosciences, Inc., including serving as chair of the nominating and corporate governance committee and as a member of the audit committee. She also chairs the board of visitors for the Smeal College of Business of Pennsylvania State University as well as serves on the board of directors of The New Xellia Group. She previously served on the board of directors for ViroPharma Inc., Epirus Biopharmaceuticals, Inc., the Biotechnology Industry Organization, the Pennsylvania Biotechnology Association and the New England Healthcare Institute.

Ms. McHugh received her M.B.A. degree from St. Joseph's University and her B.S. degree from Pennsylvania State University.

Ms. McHugh's experience as a chief executive officer and a chief operating officer at large multinational pharmaceutical companies makes her a valuable member of our board of directors. Her deep knowledge of Ironwood's history and strategy and strong relationships with our senior leadership team also make her a valuable resource, particularly during the chief executive officer transition period.

10    Ironwood


Table of Contents

GRAPHIC



EDWARD P.
OWENS

Former Partner, Portfolio Manager
and Global Industry Analyst,
Wellington Management
Company, LLP

Age: 74

Director since 2013

Board Committees

Audit Committee

Mr. Owens was previously partner, portfolio manager and global industry analyst with Wellington Management Company, LLP where he worked in investment management from 1974 to 2012. He was the portfolio manager of the Vanguard Health Care Fund for 28 years from its inception in May 1984 until his retirement from Wellington in December 2012.

Mr. Owens serves on the board of directors of Stealth BioTherapeutics Corp and ESCAPE Bio. He has a B.S. in physics from the University of Virginia and an M.B.A. from Harvard Business School.

He brings to our board of directors extensive experience in evaluating and investing in life sciences companies, providing valuable insight as we continue to strive towards our goal of maximizing long-term stockholder value.

2021  Proxy Statement    11


Table of Contents

GRAPHIC

How We are Selected and Evaluated

We believe that our board of directors should be comprised of individuals with sophistication and experience in many substantive areas that will help us achieve our vision of becoming a leading U.S. GI healthcare company dedicated to advancing the treatment of GI diseases and redefining the standard of care for GI patients.

The core criteria that we use in evaluating each nominee to our board of directors consists of the following: (a) an owner-orientedowner oriented attitude and a commitment to represent the interests of our stockholders, demonstrated, in part, through ownership of our stock; (b) strong personal and professional ethics, integrity and values; (c) strong business acumen and savvy; (d) a deep, genuine passion for our business and the patients whom we serve; (e) demonstrated achievement in the nominee'snominee’s field of expertise; (f) the absence of conflicts of interest that would impair the nominee'snominee’s ability to represent the interests of our stockholders; (g) the ability to dedicate the time necessary to regularly participate in meetings of the board and committees of our board; and (h) the potential to contribute to the diversity of our board of directors, as a result of the nominee'snominee’s professional background, expertise, gender, age, ethnicity or ethnicity.

other diversity criteria.

As illustrated in the matrix below, we believe our directorsboard of director nominees possess the professional and personal qualifications and necessary expertise both within and outside of the healthcare industry to maintain a diverse and experienced board of directors that can effectively represent stockholders.

[MISSING IMAGE: bc_line-4c.jpg]
Ironwood Board of
Directors









Broader BusinessHealthcare Industry
Capital
Allocation /

Finance /
Accounting
Strategic
Transactions
Risk
Management
Human
Capital
Public
Company
Board
Senior
Leadership
(small
biotech)
Senior
Leadership
(large
pharma)
Customer /
Market Insights
(patient, payer,
physician)
Mark Currie, Ph.D.

Broader BusinessHealthcare Industry
Ironwood Board of Directors
Capital
Allocation /
Finance /
Accounting

Strategic
Transactions

Risk
Management

Human
Capital

Public
Company
Board

Senior
Leadership
(small
biotech)

Senior
Leadership
(large
pharma)

Customer /
Market Insights
(patient, payer,
physician)

Julie H. McHugh

Andrew Dreyfus

Lawrence S. Olanoff, M.D., Ph.D.

Jon R. Duane

Edward P. Owens

Mark G. Currie, Ph.D.

Marla L. Kessler

Catherine Moukheibir

Alexander J. Denner, Ph.D.

Jay P. Shepard

Alexander Denner, Ph.D.
Andrew Dreyfus
Jon Duane
Marla Kessler
Thomas McCourt
Julie McHugh
Catherine Moukheibir
Jay Shepard


14   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Board Diversity
We believe our board of directors should be comprised of individuals reflecting the diversity represented by our employees and our patients. As mentioned above under How We are Selected and Evaluated, we have core criteria that we evaluate each board of director nominee on, including but not limited to, the potential to contribute to the diversity of our board of directors, as a result of the nominee’s professional background, expertise, gender, age, ethnicity or other diversity criteria. Three of our nine current directors are women, one of whom self-identifies as Middle Eastern. The table below provides additional diversity information regarding our board of directors. Each of the categories listed in the below table has the meaning as it is used in Nasdaq Listing Rule 5605(f).
[MISSING IMAGE: bc_line-4c.jpg]
Board Diversity Matrix (as of April 25, 2024)
Board Size:
Total Number of Directors9
Gender Identity:FemaleMaleNon-BinaryDid Not Disclose
Directors351
Demographic Background:
African American or Black
Alaskan Native or Native American
Asian
Hispanic or Latinx
Native Hawaiian or Pacific Islander
White25
Two or More Races or Ethnicities
LGBTQ+
Did Not Disclose Demographic Background1
Directors who self-identify as Middle Eastern1
Director Succession Planning

We refresh our board of directors and assess our board succession plans regularly. As of April 20, 2021,25, 2024, the average age of our independent directors'directors was 6162 years, and the average tenure of our independent directors was approximately 3.85.6 years. Six of our ten directors joined our board of directors since our separation, or Separation,

12    Ironwood


Table of Contents

GRAPHIC

from Cyclerion Therapeutics, Inc., or Cyclerion, in April 2019, including two directors, Dr. Denner and Mr. Shepard, who joined our board of directors in 2020.

Annual Evaluations

Our directors conduct annual evaluations to assess the performance and effectiveness of the board of directors and each committee in which they are a member. In addition, each director completes a self-evaluationmember, as well as a peerto provide an opportunity for each director to provide an evaluation of eachthe other director.directors. For 2020, each director, except Dr. Denner and Mr. Shepard,2023, directors completed a written questionnairequestionnaires, which solicited open-endedopen- ended and candid feedback on an anonymous basis. Dr. Denner and Mr. Shepard did not complete a written questionnaire as they joined the board of directors in the fourth quarter of 2020. In addition to the director evaluations, we also solicit annual feedback from senior management concerning the board'sboard’s performance on an anonymous basis. After the collective board and committee evaluations and comments (including those from senior management) and the self and peer evaluations andevaluation comments were compiled, the chair of the governance and nominating committee met with our chair of the board and Mark Mallon, our former chief executive officer, to discuss the board and committee evaluations and individual evaluations for directors. The chair of the governance and nominating committee also conducted individual feedback sessions with each director (except Dr. Denner and Mr. Shepard) to discuss the results of his or her individual evaluation and then provided the governance and nominating committee with a summary of the individual evaluations for the Class I and Class II directors up for election at the 2021 annual meeting of stockholders. The chair of the governance and nominating committee then presented a summary of the collective

2024 Proxy Statement   15

[MISSING IMAGE: hr_greenltsm-4c.jpg]
board and committee evaluations and comments (including those from senior management) to the governance and nominating committee and full board of directors.

Director Nomination Process

Our governance and nominating committee identifies potential director candidates through referrals and recommendations, including from incumbent directors, management and stockholders, as well as through business and other organizational networks and relationships. The boardWe and management had built a strong relationship with Dr. Denner from his role as chief investment officer of Sarissa Capital Management LP, one of Ironwood's largest stockholders, and valued his significant experience overseeing the operations of healthcare companies. For that reason, our governance and nominating committee recommended and the board elected Alexander J. Denner, Ph.D. to join our board effectiveof directors retain executive search firms and other third parties from time to time to assist in November 2020. In 2020, we also worked with a leadership consulting firm to identify opportunities to build on capabilities we believed were necessary to execute on our strategic priorities. In connection with that process, we identified an opportunity to add a director with experience as a chief executive officer in the pharmaceutical industry with a history of value creation through inorganic growth to our board. We then retained a search firm to identify candidates that met these qualifications and, through that process, identified Jay P. Shepard, who the governance and nominating committee recommended and the board elected to join our board effective in December 2020.

finding suitable candidates.

Stockholders who wish to recommend candidates may contact the governance and nominating committee in the manner described in Stockholder Communications, Proposals and Nominations for Directorships—Directorships — Communications. Stockholder-recommendedStockholder recommended candidates whose recommendations comply with these procedures will be evaluated by the governance and nominating committee in the same manner as candidates identified by the governance and nominating committee.

2021  Proxy Statement    13


Table of Contents


GRAPHIC
16   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
How We are Organized and Governed
Corporate Governance Highlights
[MISSING IMAGE: bc_line-4c.jpg]

How We are Organized

Number of Independent Directors/Total Number of Directors8/9
All Board Committees Comprised Solely of Independent Directors
Separate Independent Chair and Governed

Chief Executive Officer Positions
Regular Executive Sessions of Independent Directors
Annual Board and Committee Assessments
Annual Election of All Directors
Annual Advisory Stockholder Vote on Executive Compensation
Stock Ownership Guidelines for Directors and Executive Officers
Comprehensive Code of Business Conduct and Ethics
Corporate Governance Guidelines
Prohibition of Hedging and Pledging by Executive Officers and Directors
Anti-Overboarding Policy Limiting the Number of Other Public Company Boards on which our Directors May Serve
Clawback Policy

Board Size and Terms

Our Eleventh Amended and Restated Certificate of Incorporation, as amended, or our Certificate of Incorporation, states that our board of directors shall consist of between one and 15 members, and the precise number of directors shall be fixed by a resolution of our board of directors. Our board of directors currently consists of tennine members.
Each director holds office until his or her successor is duly elected and qualified or until his or her death, resignation or removal. Any vacancy on the board of directors, including a vacancy that results from an increase in the number of directors, may be filled by a vote of the majority of the directors then in office. Any additional directorships resulting from an increase in the number of directors will be apportioned by our board of directors among the three classes until the declassification
All of our board of directors as described further below.

In accordance with the terms of our Certificate of Incorporation, our board of directors is currently divided into three classes, which has resulted in staggered elections. Upon the expiration of the one-year term of a class of directors, directors in that class will be eligible to be nominated andare elected for a new one-year term at the annual meeting in the year in which their term expires. The current members of each class are set forth in the table above under Who We Are.

On the recommendation of our board of directors, our stockholders voted at our 2019 annual meeting of stockholders to amend our Certificate of Incorporation to declassify our board of directors to allow the company's stockholders to vote on the election of the entire board of directors on an annual basis rather than on a staggered basis. Consistent with the amendment to our Certificate of Incorporation that was approved by our stockholders, the declassification of the board of directors is being phased in as follows:

    at our 2020 annual meeting of stockholders, the Class I directors stood for election for a one-year term;

    at our 2021 annual meeting of stockholders, the Class I and Class II directors will stand for election for a one-year term; and

    at our 2022 annual meeting of stockholders, and at each annual meeting of stockholders thereafter, all directors will stand for election for one-year terms.

For so long as our board of directors is classified, directors maycan be removed by our stockholders only for cause. Following the declassification of our board of directors, our directors will be removable with or without cause by our stockholders.

We separate the roles of chair of the board of directors and chief executive officer and rotate the chair approximately every five years, unless the governance and nominating committee recommends otherwise. Our board of directors believes that this structure enhances the board of directors'directors’ oversight of, and independence from, management, and enables the board of directors to carry out its responsibilities on behalf of our stockholders. This leadership structure also allows our chief executive officer to focus his or her time and energy on operating and managing the company, while leveraging the experience and perspective of Ms. McHugh, the current chair of our board of directors. We expect the nextThe governance and nominating committee has determined that Ms. McHugh should continue to serve as chair rotation will take place in 2024.

of our board of directors.

Director Independence

Under Nasdaq Rule 5605, a majority of a listed company'scompany’s board of directors must be comprised of independent directors. In addition, Nasdaq rules require that, subject to specified exceptions, each member of a listed company'scompany’s audit, compensation and governance and nominating committees be independent, and that audit and compensation committee members satisfy the additional independence criteria set forth in Rule 10A-3 and 10C-1, respectively, under

2024 Proxy Statement   17

[MISSING IMAGE: hr_greenltsm-4c.jpg]
the Securities Exchange Act of 1934, as amended, or the Exchange Act. Under Nasdaq Rule 5605(a)(2), a director will only qualify as an "independent director"“independent director” if, in the opinion of that company's

14    Ironwood


Table of Contents

GRAPHIC

company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director.

Our board of directors determined that none of Messrs. Dreyfus, Duane Owens and Shepard, Mses. Kessler, McHugh and Moukheibir, and Drs. Currie and Denner, and Olanoff, representing nineeight of our tennine directors, has a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director and that each of these directors is "independent"“independent” as that term is defined under Nasdaq Rule 5605(a)(2). Dr. Currie, who served asMr. McCourt, our senior vice president, chief scientificexecutive officer, and president of R&D until the Separation in April 2019, was not determined to be independent due to his recent employment with the company. Our board of directors also determined that each of the current members of our audit committee, our governance and nominating committee, and our compensation and HR committee satisfies the independence standards for such committee established by Rule 10A-3 and 10C-1 under the Exchange Act, the SEC rules and the Nasdaq rules, as applicable. In making such determinations, our board of directors considered the information requested from and provided by each director concerning the director'sdirector’s background, employment and affiliations, including family relationships, the relationships that each such non-employee director has with Ironwood and all other facts and circumstances the board of directors deemed relevant in assessing independence. As part of such determination, the board of directors considered: (a) the additional time Ms. McHugh is spending providing counsel and guidance to the Company's senior leadership team during the chief executive officer transition period and the related incremental chair retainer and equity grant recommended by the compensation and HR committee and approved by the board of directors (as described elsewhere in this proxy statement under the caption Additional Chair Compensation), (b) the volume of business between BCBSMA, the company in which Mr. Dreyfus servesconsidered Dr. Currie’s previous employment as president and chief executive officer, and Ironwood, which amounted to less than 1% of the annual revenues of BCBSMA in 2020; and (c) payments made by Ironwood to IQVIA, the company in which Ms. Kessler served as the formerour senior vice president, for strategy, marketingchief scientific officer and communications and former adviser to the chief executive officer, which amounted to less than 1%president of the annual revenues of IQVIA in 2020.

R&D until April 2019.

Risk Oversight

Our board of directors retains ultimate responsibility for risk oversight and our management team retains the responsibility for risk management. In carrying out its risk oversight responsibilities, our board of directors reviews the long- and short-term internal and external risks facing the company through its participation in long-range strategic planning, and the annual review and evaluation of corporate risks that the audit committee reports. Our board of directors also believes that separating the roles of chair of the board of directors and chief executive officer enhances the board of directors'directors’ ability to oversee risk in an objective manner.

We have implemented and continue to refine a formalized enterprise risk management process. On an ongoing basis, we identify key risks, assess their potential impact and likelihood, and, where appropriate, implement operational measures and controls or purchase insurance coverage in order to help ensure adequate risk mitigation. Together with our board of directors, we continue to closely monitor the developments and impact of COVID-19 on our business and operations, including employees, and work diligently to quickly address and mitigate risks in the evolving and dynamic environment.

On a quarterly basis, key risks, status of mitigation activities and potential new or emerging risks are reported to and discussed with senior management and further addressed with our audit committee and board of directors, as necessary. On at least an annual basis, a long-term comprehensive enterprise risk management update is provided to our board of directors. The long-term goal of our enterprise risk management process is to ingrain a culture of risk awareness and mitigation throughout the organization that can be applied to our current business activities as well as our assessment and pursuit of future business opportunities.

2021  Proxy Statement    15


Table of Contents

GRAPHIC

As set forth in its charter, our audit committee discusses with management any significant risks or exposures facing Ironwood, evaluates the steps management has taken or proposes to take to mitigate such risks and reviews our compliance with such mitigation plans. As part of fulfilling these responsibilities, the audit committee meets regularly with Ernst & Young LLP, our independent registered public accounting firm, and members of our management, including our chief executive officer and chief financial officer. Additionally, our audit committee oversees our cybersecurity risk and receives regular reports, with a minimum frequency of once per year, from our Chief Information Officer on various cybersecurity matters, including risk assessments, mitigation strategies, areas of emerging risks, incidents and industry trends and other areas of importance. Our audit committee also discusses with Ernst & Young LLP any significant risks or exposures facing the company to the extent that such risks or exposures relate to accounting and financial reporting and reviews related mitigation plans with Ernst & Young LLP. In addition, our audit committee reviews the risk factors as presented in our annual reports on Form 10-K and our quarterly reports on Form 10-Q, as applicable, that we file with the SEC.

As part of our board of directors'directors’ risk oversight role, our compensation and HR committee reviews and evaluates the risks associated with our compensation programs and succession plans. The compensation and HR committee also is

18   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
responsible under its charter for approving the compensation of all of our executive officers (other than our chief executive officer), recommending chief executive officer compensation to our board of directors for approval and overseeing the maintenance and presentation to our board of directors of succession plans for members of our senior management. Likewise, our governance and nominating committee is responsible for evaluating the performance, operations and composition of our board of directors and the sufficiency of our corporate governance guidelines, either of which may impact our risk profile from a governance perspective.

In performing their risk oversight functions, each committee of our board of directors has full access to management, as well as the ability to engage outside advisors.

Hedging and Pledging Policy

As part of our insider trading prevention policy, our directors and executive officers are prohibited from engaging in any hedging or monetization transactions of our company securities, including through the use of financial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds. In addition, our insider trading prevention policy generally prohibits our directors and executive officers from holding company securities in a margin account or pledging company securities as collateral for a loan.

Corporate Governance Guidelines

We have adopted corporate governance guidelines which are accessible through the Investors section of our website at www.ironwoodpharma.com, under the heading Corporate Governance — Governance Documents, and which are available in print to any stockholder who requests them from our secretary. Our board of directors believes that sound governance practices and policies provide an important framework to assist it in fulfilling its duties to stockholders and relies on these guidelines to provide that framework. Among other things, theThe guidelines help to ensure that our board of directors is independent from management, that our board of directors adequately performs its oversight functions and that the interests of our board of directors and management align with the interests of our stockholders.

Equality, Among other things, our corporate governance guidelines limit the number of other public company boards on which our directors may serve. Accordingly, our directors should not serve on more than four public company boards of directors, including Ironwood. In addition, our directors who hold the position of chief executive officer of a public company should not serve on more than three public company boards of directors, including Ironwood and the board of his or her own company. Our governance and nominating committee conducts an annual review of director commitment levels, and affirms that as of March 31, 2024, all directors were in compliance with our corporate governance guidelines.

Diversity, andEquity & Inclusion

We believe that creating an (DE&I)

Creating a diverse, equitable diverse, and inclusive culture is criticalessential to attracting, motivating and retaining the talent necessary to deliver on our mission,corporate mission. To establish and our compensation HR committee actively engages with management on matters such as employee development, corporatemaintain this culture, and engagement, as well as equality, diversity and inclusion, or EDI, initiatives.

In 2020, we established an EDI working group dedicatedhave a simple vision in mind: to advancing key EDI initiatives. Ironwood's leadership team and board of directors champions these efforts. In October 2020, our management adopted a long-term EDI strategy and, in January 2021, our board of directors approved a specific corporate goal for 2021 aimed at

16make Ironwood


Table of Contents

GRAPHIC

fostering an environment where employees feel includedrooted in valuing each employee for who they are.

This begins with ensuring our workforce represents the diverse populations we serve and empowered. Current EDI initiatives include empoweringreflecting our employee resource groups, such as IronwomenDE&I principles in our employee-related training and Ironwood Stands Together Against Racism, or ISTAR, introducing new learning and development opportunities, strengthening our talent acquisition strategies and introducing new metrics and measurements on outreach to diverse candidate sources, retention, career advancement and employee survey feedback from diverse populations.

policies. As of December 31, 2020,2023, women represented approximately 50% of our employees are women, and women represent approximately 30%employee base, 20% of our leadership team (vice president and above) and nearly 30%33% of our board of directors (including our board and audit committee chairs). Additionally, as of December 31, 2023, approximately 20% of our employees arewere racially or ethnically diverse and in 2020,2023, approximately 40% of our new hires were racially or ethnically diverse.

diverse (excluding Europe-based employees, for which race and ethnicity is not disclosed).

We are focused on fostering an environment where employees feel included and empowered. This approach includes DE&I initiatives such as learning and development opportunities, strengthened talent acquisition strategies, the support of equality programs in our local communities, and a renewed focus on retention and career advancement of diverse populations. We were proud to have five strong DE&I employee resource groups during 2023: (1) W@IRWD (Women at Ironwood), designed to empower, develop, and sponsor women at Ironwood, (2) ISHINE (Ironwood Sponsoring Historically Black Colleges and Universities Student Internships Nurturing Excellence), which draws undergraduate candidates from Historically Black Colleges and Universities and exposes students to careers in the healthcare field, (3) ISTAR (Ironwood Stands Together Against Racism), which was created in response to racial equality movements and

2024 Proxy Statement   19

[MISSING IMAGE: hr_greenltsm-4c.jpg]
our employees’ drive to take action, (4) PRIDE@IRWD, which seeks to foster LGBTQ+ visibility for all Ironwood employees and raise awareness about the current workplace and social issues that affect the LGBTQ+ community, and (5) IMPACT (Ironwood Makes Positive Advances in our Communities Together), which offers a space for bettering our communities and engaging deeper with one another.
In 2023, we continued to advance our DE&I initiatives with strong advocacy from our leadership team and board of directors.
We are committed to furthering our DE&I efforts consistent with our long-term DE&I strategy, including by incorporating DE&I metrics into our corporate goals.
Board Meetings

Our board of directors held nine meetings during 2020.2023. As stated in our corporate governance guidelines, we expect our directors to rigorously prepare for, attend and participate in all board and applicable committee meetings. Each director is expected to ensure that other existing and planned future commitments do not materially interfere with his or her service as a director. We also expect that all of our directors will attend our annual meeting of stockholders unless a director will not be continuing to serve on the board following such annual meeting. In 2020,2023, each incumbent director attended at least 75% of all meetings of the board of directors and all committees of the board of directors on which he or she served that were held during the period that such director was a member of the board of directors or the applicable committee. Eight of ourAll nine directors at the time of our 20202023 annual meeting of stockholders attendedwere present at the meeting.

Committees

Our board of directors has established three standing committees: an audit committee, a governance and nominating committee and a compensation and HR committee. Each of the audit committee, the governance and nominating committee and the compensation and HR committee operates under a charter approved by our board of directors. Copies of each charter are accessible through the Investors section of our website at www.ironwoodpharma.com, under the heading Corporate Governance — Governance Documents, and are available in print to any stockholder who requests them from our secretary. The chair of each of our committees is expected to rotate approximately every three to five years, unless the governance and nominating committee recommends otherwise.

Audit Committee

We have a separately designated standing audit committee established by our board of directors for the purpose of overseeing our accounting and financial reporting processes and audits of our financial statements. The members of our audit committee are Mses. Moukheibir and McHugh and Messrs. Owens andMr. Shepard.

Ms. Moukheibir chairs the audit committee.committee, and our board of directors has determined that Ms. Moukheibir is an audit committee financial expert, as defined in Item 407(d)(5) of Regulation S-K. Our audit committee met four times during 2020.2023. Our audit committee assists our board of directors in its oversight of significant risks facing Ironwood, the integrity of our financial statements and our independent registered public accounting firm'sfirm’s qualifications, independence and performance.

Our audit committee'scommittee’s responsibilities include:


reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements, earnings releases and related disclosures;


reviewing and discussing with management and our independent registered public accounting firm and, as needed, internal auditors or any relevant third party, the quality and adequacy of our internal controls and internal auditing procedures, including any material weaknesses;

2021  Proxy Statement    17


Table of Contents

GRAPHIC weaknesses or significant deficiencies;

    discussing our accounting policies and all material correcting adjustments with our management and our independent registered public accounting firm;


discussing with our management any significant risks or exposures facing the company and the related mitigation plans, and discussing with our independent registered public accounting firm any significant risks or

20   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
exposures facing the company to the extent that such risks or exposures relate to accounting and financial reporting and related mitigation plans;


monitoring our internal control over financial reporting and disclosure controls and procedures;


reviewing and assessing the adequacy of the company’s information technology systems, processes, controls and data and periodically (but no less than annually), reviewing and assessing with management and internal auditors the company’s assessment of risks from cybersecurity threats, the adequacy of the information security program for the company’s information technology systems, processes and data;

working with management to formulate a mitigation plan and reviewing the company'scompany’s compliance, as well as ensuring compliance with any external regulatory or disclosure requirements, with such mitigation plan in the event of a significant breakdowncybersecurity incident or security breach affecting the information technology systems of the company or a third party;

the company’s data;

appointing, retaining, evaluating, overseeing, and approving the compensation for and, when necessary, terminating our independent registered public accounting firm;


approving all audit services and all permitted non-audit, tax and other services to be performed by our independent registered public accounting firm, in each case, in accordance with the audit committee'scommittee’s pre-approval policy;


discussing with the independent registered public accounting firm its independence and ensuring that it receives the written disclosures regarding these communications required by the Public Company Accounting Oversight Board, or PCAOB;


reviewing with the independent registered public accounting firm, to the extent applicable, any matter arising from the audit of the financial statements that was communicated or required to be communicated that both relates to accounts or disclosures that are material to the financial statements and involves especially challenging, subjective or complex auditor judgment;


reviewing and approving all transactions or series of similar transactions to which we were or are a party in which the amount involved exceeded or exceeds $120,000 and in which any of our directors, executive officers, holders of more than 5% of any class of our voting securities, or any member of the immediate family of any of the foregoing persons, had or will have a direct or indirect material interest, other than compensation arrangements with directors and executive officers;


recommending whether the audited financial statements should be included in our annual report and preparing the audit committee report required by SEC rules;


reviewing with our independent registered public accounting firm all material communications between our management and our independent registered public accounting firm;


reviewing, updating and recommending to our board of directors approval of our code of business conduct and ethics; and


establishing procedures for the receipt, retention, investigation and treatment of accounting related complaints and concerns.

Our board of directors has determined that Ms. Moukheibir is an audit committee financial expert, as defined in Item 407(d)(5) of Regulation S-K.

18    Ironwood


Table of Contents


GRAPHIC
2024 Proxy Statement   21

[MISSING IMAGE: hr_greenltsm-4c.jpg]

Audit Committee Report

In the course of our oversight of Ironwood'sIronwood’s financial reporting process, we have (i) reviewed and discussed with management the company'scompany’s audited financial statements for the fiscal year ended December 31, 2020,2023, (ii) discussed with Ernst & Young LLP, the company'scompany’s independent registered public accounting firm, the matters required to be discussed by the applicable requirements of the PCAOB and the SEC, and (iii) received the written disclosures and the letter from Ernst & Young LLP, the company'scompany’s independent registered public accounting firm, required by applicable requirements of the PCAOB regarding the independent registered public accounting firm'sfirm’s communications with us concerning independence, discussed with the independent registered public accounting firm its independence, and considered whether the provision of non-audit services by the independent registered public accounting firm is compatible with maintaining its independence.

Based on the foregoing review and discussions, we recommended to the board of directors of the company that the audited financial statements be included in the company'scompany’s Annual Report on Form 10-K for the year ended December 31, 20202023 for filing with the SEC.

By the Audit Committee,
Catherine Moukheibir, Chair
Julie McHugh
Jay Shepard

22   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
By the Audit Committee,



Catherine Moukheibir, Chair
Julie H. McHugh
Edward P. Owens
Jay P. Shepard

2021  Proxy Statement    19


Table of Contents

GRAPHIC

Governance and Nominating Committee

The members of our governance and nominating committee are Drs.Dr. Denner, and Olanoff, Mr. Duane and Ms. McHugh. Dr. OlanoffDenner chairs the governance and nominating committee. Our governance and nominating committee met fourtwo times during 2020.

2023.

Our governance and nominating committee'scommittee’s responsibilities include:


assisting our board of directors in identifying and recruiting individuals qualified to become members of our board of directors;


recommending to our board of directors the persons to be nominated for election as directors;


recommending to our board of directors qualified individuals to serve as committee members;


performing an annual evaluation of our board of directors and each committee of the board of directors;


evaluating the need and, if necessary, creating a plan for the continuing education of our directors;


assessing and reviewing our corporate governance guidelines and recommending any changes to our board of directors;


considering any potential conflicts of interest of members of our board of directors;


considering our policies with respect to their impact on significant issues of corporate social responsibility; and


evaluating and approving any requests from our executives to serve on the board of directors of another for-profit company.

Compensation and HR Committee

The members of our compensation and HR committee are Dr. Currie, Messrs. Dreyfus and Duane and Ms. Kessler. Mr. Dreyfus chairs our compensation and HR committee. Our compensation and HR committee met fivesix times during 2020.2023. Our compensation and HR committee assists our board of directors in fulfilling its responsibilities relating to the compensation of our board of directors and our executive officers.

officers, and oversees matters related to human capital management, including DE&I, workplace environment and culture and talent development and retention.

Our compensation and HR committee'scommittee’s responsibilities include:

reviewing
evaluating the performance of our chief executive officer and approvingother executive officers in light of pre-determined corporate goals and objectives relevant to the chief executive officer compensation and evaluating the performance ofofficer’s or such executive officers in light of those goals and objectives;

officer’s compensation;

reviewing and recommending to the board our chief executive officer'sofficer’s compensation based on its evaluationincluding salary, bonus and incentive compensation, deferred compensation, perquisites, equity compensation, benefits provided upon retirement, severance or other termination of the chiefemployment, and any other forms of executive officer's and the company's performance;

compensation;

reviewing and approving executive officer compensation (other than for the chief executive officer), including salary, bonus and incentive compensation, deferred compensation, perquisites, equity compensation, benefits provided upon retirement, severance or other termination of employment, and any other forms of executive compensation;


reviewing and approving our peer companies to evaluate our compensation competitiveness and mix of compensation elements;


overseeing and administering our incentive compensation plans and equity-based plans and recommending the adoption of new incentive compensation plans and equity-based plans to our board of directors;

20    Ironwood


Table of Contents

GRAPHIC

    reviewing, accessing and making recommendations to our board of directors with respect to director compensation;

    compensation and any stock ownership guidelines applicable to non-employee directors;

reviewing, approving and overseeing any stock ownership guidelines applicable to executive officers;


2024 Proxy Statement   23

[MISSING IMAGE: hr_greenltsm-4c.jpg]

reviewing and discussing with management the compensation discussion and analysis required to be included in our filings with the SEC and recommending whether the compensation discussion and analysis should be included in such filings;


preparing the compensation and HR committee report required by the SEC;


making recommendations to our board of directors with respect to management succession planning, including planning with respect to our chief executive officer;


overseeing compliance with applicable laws and regulations affecting employee compensation and benefits, including regarding stockholder approval of certain executive compensation matters;

overseeing, reviewing and

recommended to the board of directors for approval of any “clawback” or recoupment policy of the company for recovering incentive-based compensation and monitoring compliance therewith;

reviewing the risks associated with our compensation policies and practices.

practices; and


overseeing the company’s strategies and policies related to human capital management, including with respect to matters such as DE&I, workplace environment and culture, and talent development and retention.
Compensation Committee Interlocks and Insider Participation

None of the members of our compensation and HR committee is or has at any time during the past fiscal year been an officer or employee of Ironwood. None of the members of our compensation and HR committee has formerly been an officer of Ironwood. None of our executive officers serve, or in the past fiscal year has served, as a member of the board of directors or compensation and HR committee of any other entity that has one or more executive officers serving as a member of our board of directors or compensation and HR committee. None of the members of our compensation and HR committee had any relationship with us that requires disclosure under any paragraph of Item 404 of Regulation S-K under the Exchange Act.

How Our Board is Paid

How We Are Paid

Under our second amended and restated 2019 non-employee director compensation policy, effective May 2019,January 1, 2024, or the Director Compensation Policy, the majority of the compensation that our non-employee directors receive for service on our board of directors is paid in the form of restricted shares of our Class A common stock. Vesting of these shares of restricted stock is contingent on each non-employee director continuing to serve as a member of the board of directors on the last day of each applicable vesting period. If a director ceases serving as a member of our board of directors at any time during the vesting period of a restricted stock award, or RSA, unvested shares will be forfeited on the date of such director'sdirector’s termination of service. Shares of restricted stock granted to directors in 2020 under our director compensation policy wereDirector Compensation Policy are granted under our Amended and Restated 2019 Equity Incentive Plan, or our Amended 2019 Plan. Under our Amended 2019 Plan, the aggregate value of all compensation paid or granted to any non-employee director for his or her service as a director in any calendar year may not exceed $600,000.

Under our director compensation policy,Director Compensation Policy, at each annual meeting of stockholders, our non-employee directors are granted restricted shares of our Class A common stock, with a grant date fair valuethe number of shares subject to the award equal to $250,000 determined based ondivided by the average closing price of our Class A common stock on the Nasdaq Global Select Market (or the stock exchange on which our stock is being actively traded) for the six months preceding the month in which the award is granted, rounded down to the nearest whole share. Such restricted shares vest in full on the date immediately preceding the date of the next annual meeting of stockholders.

Each non-employee director who is first elected to our board of directors will, upon his or her initial election, be granted restricted shares of our Class A common stock, with a grant date fair valuethe number of shares subject to the award equal to $250,000 determined based ondivided by the average closing price of our Class A common stock on the Nasdaq Global Select Market (or the stock exchange on which our stock is being actively traded) for the six months preceding the month in which the

2021  Proxy Statement    21


Table of Contents

GRAPHIC

award is granted, rounded down to the nearest whole share. Such restricted shares vest in three equal installments on the first three anniversaries of the grant date. In addition, under our director compensation policy,Director Compensation Policy, if a non-employee


24   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
director is elected other than at an annual meeting of our stockholders, then upon his or her initial election to our board of directors, such director will be granted the number of restricted shares of our Class A common stock granted to non-employee directors at the most recent annual meeting of our stockholders, prorated based on the number of days between the last annual meeting of our stockholders and the date on which the non-employee director began service with us. Such restricted shares will vest in full on the date immediately preceding the date of the next annual meeting of stockholders.

In addition to equity grants, each non-employee director receives an annual retainer under our director compensation policyDirector Compensation Policy for his or her service on our board of directors, as well as additional fees for board chair, committee or committee chair service as follows:

[MISSING IMAGE: bc_line-4c.jpg]



Fees
Fees
Annual retainer for members of the board of directors$50,000 ($80,00085,000 for the chair)(1)
Additional annual retainer for members of the audit committee$10,00011,000 ($20,00025,000 for the chair)(1)
Additional annual retainer for members of the compensation and HR committee$7,50010,000 ($15,00020,000 for the chair)
Additional annual retainer for members of the governance and nominating committee$5,000 ($10,000 for the chair)

(1)
Following a competitive assessment of market data related to non-executive director compensation provided by Human Capital Solutions, Aon, or Aon, our compensation consultant at the time, the compensation and HR committee recommended, and the board approved, to amend and restate our prior amended and restated Director Compensation Policy, to increase, effective January 2024, the annual retainer for the board chair from $80,000 to $85,000, and the additional annual retainers for the members of the audit committee and for the audit committee chair from $10,000 to $11,000, and from $20,000 to $25,000, respectively.
All cash fees are payable quarterly in arrears and will be prorated for any quarter of partial service. Each non-employee director may elect, prior to January 1 of the year with respect to which such election will be effective, to receive fully vested shares of our Class A common stock at no cost in lieu of his or her annual cash retainer and any additional cash retainers for board chair, committee or committee chair service set forth above. The number of shares of our Class A common stock issued is determined by dividing the applicable cash retainer(s) the director would be eligible to receive by the closing price of our Class A common stock on the Nasdaq Global Select Market (or the stock exchange on which our stock is being actively traded) on the date the cash fees would otherwise be paid, rounded down to the nearest whole share. Further, non-employee directors are reimbursed for reasonable travel and other expenses incurred in connection with attending meetings of the board of directors and its committees.


2024 Proxy Statement   25

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Director Compensation Table

The following table sets forth information regarding the compensation earned during the year ended December 31, 20202023, by each of our directors who served in 20202023, other than Mr. Mallon, our former chief executive officer and former member of our board of directors. Mr. Mallon didMcCourt, who does not receive compensation for his service on our board of directors.

[MISSING IMAGE: bc_line-4c.jpg]
NameFees Earned or
Paid in
Cash ($)
All Other
Stock Awards
($)(1)
Compensation
($)
Total
($)
Mark Currie, Ph.D.$60,000$240,710$300,710
Alexander Denner, Ph.D.$59,976(2)$240,710$300,686
Andrew Dreyfus$70,000$240,710$310,710
Jon Duane$65,000$240,710$305,710
Marla Kessler$60,000$240,710$300,710
Julie McHugh$95,000$240,710$335,710
Catherine Moukheibir$69,978(3)$240,710$310,688
Jay Shepard$60,000$240,710$300,710
 
  
  
  
 
Name
 Fees Earned or
Paid in
Cash ($)

 Stock Awards
($)(1)

 Total
($)

 

Mark G. Currie, Ph.D.

 $50,000 $218,286 $268,286 

Alexander J. Denner, Ph.D.

 $7,912(2)$400,461(4)$408,373 

Andrew Dreyfus

 $64,977(3)$218,286 $283,263 

Jon R. Duane

 $62,500 $218,286 $280,786 

Marla L. Kessler

 $57,500 $218,286 $275,786 

Julie H. McHugh

 $95,000 $218,286 $313,286 

Catherine Moukheibir

 $70,000 $218,286 $288,286 

Lawrence S. Olanoff, M.D., Ph.D.

 $60,000 $218,286 $278,286 

Edward P. Owens

 $60,000 $218,286 $278,286 

Jay P. Shepard

 $4,728 $411,750(5)$416,478 
(1)
(1)
On June 3, 2020,20, 2023, each non-employee member of our board of directors who was serving on such date received a restricted stock grant in the amount of 21,72022,350 shares of our Class A common stock for service on our board of directors from the date of our 20202023 annual meeting of stockholders to the date of our 20212024 annual meeting of stockholders, which shares will vest in full on the date immediately preceding the date of our 20212024 annual meeting of stockholders, subject to continued service on our board as of the vesting date. The number of shares subject to the restricted stock grant was determined by dividing (i) $250,000 by (ii) $11.19, which was the average closing price of our Class A common stock on the Nasdaq Global Select Market for the six months preceding the month of the 20202023 annual meeting of stockholders. Each such award of restricted stock had a grant date fair value of $10.05$10.77 per share and was granted pursuant to the terms of our director compensation policyprior amended and restated Director Compensation Policy, which was in effect from January 1, 2023 to December 31, 2023, and our 2019 Equity Plan. As of December 31, 2020,2023, each non-employee director other than Dr. Denner and Mr. Shepard held 21,72022,350 restricted shares of Class A common stock as a result of this grant and held no other unvested equity awards.


Amounts in the table represent the fair value of these restricted stock grants on the date of grant calculated in accordance with Financial Accounting Standards Board Accounting Standards Codification Topic 718, Compensation—Compensation — Stock Compensation., or ASC 718. For a discussion of the assumptions used in the valuation of awards made in 2020,2023, see Note 1413 to our consolidated financial statements for the year ended December 31, 20202023 included in our Annual Report on Form 10-K that we filed with the SEC on February 17, 2021.16, 2024. All values reported exclude the effects of potential forfeitures.

(2)

Dr. Denner joined our board of directors on November 9, 2020 and elected to receive this annual retainer in unrestricted shares of our Class A common stock. Dr. Denner received a total of 6615,942 shares of our Class A common stock for such service in 2020.

2023.
(3)
Mr. Dreyfus
Ms. Moukheibir elected to receive this annual retainer in unrestricted shares of our Class A common stock. Mr. DreyfusMs. Moukheibir received a total of 6,2986,933 shares of our Class A common stock for such service in 2020.

(4)
On November 9, 2020, in connection with his election to our board of directors, Dr. Denner received a restricted stock grant in the amount of 12,258 shares of our Class A common stock, which shares will vest in full on the date immediately preceding the date of our 2021 annual meeting of stockholders, subject to continued service on our board as of the vesting date. The number of shares subject to the restricted stock grant was determined in accordance with the proration formula related to annual equity awards for our directors set forth in our director compensation policy.


Additionally, Dr. Denner received a restricted stock grant related to his initial election to our board in the amount of 24,925 shares of our Class A common stock, which will vest in three equal installments on the first three anniversaries of the date of grant, subject to continued service on our board as of each vesting date. The number of shares subject to this restricted stock grant was determined by dividing (i) $250,000 by (ii) the average closing price of our Class A common stock on the Nasdaq Global Select Market for the six months preceding the month of the date of grant.


Each of the two awards of restricted stock had a grant date fair value of $10.77 per share and were granted pursuant to the terms of our director compensation policy and our 2019 Plan. As of December 31, 2020, Dr. Denner held 37,183 restricted shares of Class A common stock as a result of these grants and held no other unvested equity awards.

22    Ironwood


Table of Contents

GRAPHIC 2023.
(5)
On December 3, 2020, in connection with his election to our board of directors, Mr. Shepard received a restricted stock grant in the amount of 10,830 shares of our Class A common stock, which shares will vest in full on the date immediately preceding the date of our 2021 annual meeting of stockholders, subject to continued service on our board as of the vesting date. The number of shares subject to such restricted stock grant was determined in accordance with the proration formula related to annual equity awards for our directors set forth in our director compensation policy.


Additionally, Mr. Shepard received a restricted stock grant related to his initial election to our board in the amount of 24,727 shares of our Class A common stock, which will vest in three equal installments on the first three anniversaries of the date of grant, subject to continued service on our board as of each vesting date. The number of shares subject to this restricted stock grant was determined by dividing (i) $250,000 by (ii) the average closing price of our Class A common stock on the Nasdaq Global Select Market for the six months preceding the month of the date of grant.


Each of the two awards of restricted stock had a grant date fair value of $11.58 per share and were granted pursuant to the terms of our director compensation policy and our 2019 Plan. As of December 31, 2020, Mr. Shepard held 35,557 restricted shares of Class A common stock as a result of these grants and held no other unvested equity awards.

Additional Chair Compensation

In connection with Mr. Mallon's resignation as our chief executive officer and a member of our board of directors, Ms. McHugh is spending additional time providing counsel and guidance to the Company's senior leadership team. In connection with her expanded responsibilities and additional time commitment, the compensation and HR committee recommended and the board of directors approved (i) additional cash compensation of $10,000 per month for Ms. McHugh, retroactive to February 15, 2021, for the period in which she serves in this expanded role (as determined by the board of directors), up to a maximum of six months, and (ii) a grant of 2,500 shares of restricted stock, to vest in full in March 2022, subject to Ms. McHugh's continued service on our board of directors through such vesting date. In making its recommendation to the board, the compensation and HR committee took into account a number of factors, including the scope of additional responsibility and anticipated duration and additional time associated with the expanded role, as well as market data provided by our compensation consultant, Rewards Solutions, Aon, which we refer to throughout this proxy statement as 'Aon,' related to board chair compensation.

Director Stock Ownership Guidelines

In May 2019, we

We have instituted stock ownership guidelines as part of our director compensation policyDirector Compensation Policy that provide that each non-employee director must accumulate and continuously hold shares of our Class A common stock with a value equal to or greater than three times the amount of the then-current annual retainer paid to the non-employee director for service on our board of directors (excluding any additional board chair, committee, or committee chair retainers). Non-employee directors arewere required to achieve this level of ownership by the later of (a) May 30, 2021 (the date which iswas two years from the date of our 2019 annual meeting of stockholders) and (b) two years from the date the individual began service with us,became a non-employee director, or the Ownership Date.

Compliance with the stock ownership requirements will beis measured on the date of the annual meeting of stockholders each year based on the annual retainer then in effect. Following the Ownership Date, until a non-employee director holds the required ownership level and(or if such director does not hold the number of shares of our Class A common stock to meet the stock ownership requirements at any time thereafter,thereafter), such director will be required to retain 100% of any shares of our Class A common stock held or received upon the vesting or settlement of equity awards or the exercise of stock

26   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
options, in each case, net of shares sold to cover applicable taxes and the payment of any exercise or purchase price (if applicable). Further, following the Ownership Date, to the extent a non-employee director does not hold the number of shares of our Class A common stock that meets this threshold, such director will be automatically deemed to have elected to receive any cash retainer for service on our board of directors or a committee thereof in the form of shares of our Class A common stock in an amount that satisfies the threshold shortfall.

2021  Proxy Statement    23


Table As of Contents

GRAPHIC

In addition to theMarch 31, 2024, each of our non-employee directors was in compliance with our stock ownership guidelines described above, no director may transfer any shares of restricted stock granted pursuant to our director compensation policy that was effective between January 2014 and May 2019, whether the shares of restricted stock are vested or not, while such person is a director of Ironwood, subject to limited exceptions.

guidelines.

We believe our stock ownership guidelines and other transfer restrictions ensure that the interests of our directors, each of whom has equity in the business, are aligned with those of our stockholders and further focus our directors on maximizing long-term value.

24    Ironwood


Table of Contents

GRAPHIC


Table of Contents


GRAPHIC
2024 Proxy Statement   27

[MISSING IMAGE: cv_ibc-4c.jpg]
Proposal No. 1
Election
of Directors

Proposal No. 1

[MISSING IMAGE: ic_check-pn.gif]
OUR BOARD RECOMMENDS
THAT YOU VOTE
FOR
EACH OF THE DIRECTORS
UP FOR ELECTION

In furtherance of the phased-in board declassification process described elsewhere in this proxy statement under the caption Board Size and Terms, our

[MISSING IMAGE: ic_prop1-bw.gif]

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Proposal No. 1
Our board of directors has nominated eachall of our nine current Class I directors—directors  —  Drs. Currie and Denner, and Mr. Duane—and Class II directors—Mses. Kessler and Moukheibir, Dr. Olanoff and Mr. Shepard—for election at the 2021 annual meeting. Each of Drs. Currie, Denner and Olanoff, Messrs. Dreyfus, Duane, McCourt and Shepard and Mses. Kessler, McHugh and Moukheibir  —  for election at the 2024 annual meeting of stockholders. Each of Drs. Currie and Denner, Messrs. Dreyfus, Duane, McCourt and Shepard and Mses. Kessler, McHugh and Moukheibir has indicated his or her willingness to serve if elected and has consented to be named in the proxy statement. Should any nominee become unavailable for election at the annual meeting, the persons named on the enclosed proxy card as proxy holders may vote all proxies given in response to this solicitation for the election of a substitute nominee chosen by our board of directors.

Vote Required

The sevenelection of the board of director nominees forwill be determined by a plurality of the votes cast, meaning that board of director nominees with the highestgreatest number of affirmative votes cast for election, even if less than a majority, will be elected as directors to serve for one year and until their successors arehis or her successor is duly elected and qualified or until their death, resignation or removal. Because there is no minimum vote required, abstentions and broker non-votes will not affect the outcome of this proposal.

2021


2024 Proxy Statement   27


Table of Contents

29

GRAPHIC TABLE OF CONTENTS
[MISSING IMAGE: htr_bluegreen-4c.jpg]
Our Executives


Who We Are

The following table sets forth certain information, as of April 22, 2021,25, 2024, with respect to each of our executive officers.

officers, other than Mr. McCourt, whose biographical information is included elsewhere in this proxy statement under the caption Our Board of Directors:
[MISSING IMAGE: bc_line-4c.jpg]

Name

AgePosition(s)
AgePosition(s)

Gina Consylman, CPA

Andrew Davis4938Senior Vice President, Chief Business Officer
Sravan Emany46Senior Vice President, Chief Financial Officer

Thomas McCourt

63President and Interim Chief Executive Officer

Jason Rickard

John Minardo5049Senior Vice President, Chief OperatingLegal Officer and Secretary

Michael Shetzline, M.D., Ph.D.

62
65
Senior Vice President, Chief Medical Officer Senior Vice President and Head of Research and Drug Development





GINA
CONSYLMAN, CPA

ANDREW DAVIS
Senior Vice President, Chief
Financial
Business
Officer of Ironwood

Pharmaceuticals, Inc.

Age: 49

38

Joined Ironwood 2014

2021

Ms. Consylman

Andrew Davis has served as our chief business officer since December 2021.He previously served as senior vice president chief financial officer since November 2017. Ms. Consylman previouslycorporate development, strategy, and valuation from July 2021 to December 2021, and as senior vice president of business development from May 2021 to July 2021.

Before joining Ironwood, Mr. Davis served as our interimthe chief financialbusiness development and M&A officer at iNova Pharmaceuticals from September 2017 to November 2017,May 2021, leading all company transactions and as our vice president of finance and chief accounting officer from August 2015 to November 2017. She also previously served as our vice president, corporate controller and chief accounting officer from 2014 to 2015.

Prior to joining Ironwood, Ms. Consylman served as vice president, corporate controller and principal accounting officer of Analogic Corporation, or Analogic, (which was acquired by funds affiliated with Altaris Capital Partners, LLC) from 2012 to 2014, where she oversaw Analogic's global accounting team.

Prior to joining Analogic, Ms. Consylman served in various finance roles at Biogen Inc., or Biogen, from 2009 to 2012, culminating in her service as senior director, corporate accounting where she was responsible for the accounting teams for the corporate and U.S. commercial business units.

Before joining Biogen, Ms. Consylman also served as corporate controller at Varian Semiconductor Equipment Associates, Inc. (subsequently acquired by Applied Materials, Inc.)

Ms. Consylman currently serves on the board of directors and chair of the audit committee of Verastem, Inc. andacting as a member of the board of directors and member of the audit committee of Assembly Biosciences, Inc. Ms. Consylman, a Certified Public Accountant, began her career in public accounting at Ernst & Young LLP. She holds a B.S. in accounting from Johnson & Wales University and a M.S. in taxation from Bentley University.

28    Ironwood


Table of Contents

GRAPHIC





THOMAS McCOURT

President and Interim Chief
Executive Officer of Ironwood
Pharmaceuticals, Inc.

Age: 63

Joined Ironwood 2009

Mr. McCourt has served as our president since April 2019 and as our interim chief executive officer since Mr. Mallon's resignation in March 2021.management team. Prior to April 2019,iNova, Mr. McCourt servedDavis was head of oncology business development for Merck & Co. from November 2016 to September 2017. Before his time at Merck, Mr. Davis was at Bausch Health Companies (formerly Valeant Pharmaceuticals), where he held roles of increasing responsibility within the business development function, ultimately serving as our senior vice president of marketingbusiness development and sales and chief commercial officer since joining Ironwood in 2009.

Prior to joining Ironwood, Mr. McCourt led the U.S. brand team for denosumab at Amgen Inc. from 2008 to 2009. Prior to that, Mr. McCourt was with Novartis AG from 2001 to 2008, where he directed the launch and growth of ZELNORM™leading all transactions for the treatmentcompany, including the acquisitions of patients with IBS-CSalix Pharmaceuticals and CIC and held a number of senior commercial roles, including vice president of strategic marketing and operations.

Bausch + Lomb. Mr. McCourt was also part ofDavis began his career as an analyst at McKinsey & Co., where his work focused on the founding team at Astra-Merck Inc., leading the development of the medical affairs and science liaison group and then serving as brand manager for PRILOSEC® and NEXIUM®.

healthcare space.


Mr. McCourtDavis serves on the board of directors of Acceleron Pharma Inc., including asUTILITY therapeutics Ltd.

Mr. Davis holds a member of the audit committee and the chair of the nominating and governance committee, and on the board of trustees for the American Society of Gastrointestinal Endoscopy (ASGE). Mr. McCourt has a degreeB.A. in pharmacyeconomics from the University of Wisconsin.

Boston University.



30   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]



JASON RICKARD

SRAVAN EMANY
Senior Vice President, Chief
Operating Financial Officer of Ironwood
Pharmaceuticals, Inc.

Age: 50

46

Joined Ironwood 2012

2021


Mr. RickardEmany has served as our chief operatingfinancial officer since April 2020. Prior to his appointment as the company's senior vice president, chief operating officer, Mr. Rickard had been the company's senior vice president, operations since July 2018, in which capacity he led the company's manufacturing, pharmaceutical development, quality, human resources, information technology and facilities functions. Before becoming senior vice president, operations, Mr. Rickard served as the company's vice president global operations and information technology from July 2015 to July 2018; vice president global operations from 2014 to July 2015; vice president commercial manufacturing supply chain from 2013 to 2014; and head of supply chain from 2012 to 2013.

December 2021.


Prior to joining Ironwood, Mr. RickardEmany served as corporate vice president, commercial excellence and chief strategy officer of Integra LifeSciences Holdings Corporation, a publicly held global healthcare company, since March 2020 and as vice president of strategy, treasury and investor relations from February 2018 to March 2020. Prior to that, Mr. Emany served in various mergers and acquisitions investment banking roles at Bank of America and BofA Securities (formerly Bank of America Merrill Lynch) from September 2008 to February 2018, culminating in his service as managing director in the mergers and acquisitions group where he led numerous mergers and acquisitions in the healthcare sector. Mr. Emany also served in various other financial roles, including with Goldman Sachs Group and Morgan Stanley.

Mr. Emany serves on the board of directors of Assertio Holdings, Inc. (Nasdaq: ASRT).

Mr. Emany holds a B.A. in international relations from The Johns Hopkins University and an M.A. in international relations and international economics from The Johns Hopkins School of Advanced International Studies.
JOHN MINARDO
Senior Vice President, Chief Legal Officer and Secretary of Ironwood Pharmaceuticals, Inc.
Age: 49
Joined Ironwood 2021

Mr. Minardo has served as our chief legal officer since August 2021.

Prior to joining Ironwood, Mr. Minardo was with Genentech, Inc.Seqirus, a pharmaceutical company, where he was vice president, general counsel and a member of the Seqirus executive leadership team, leading a global legal team overseeing activities including business transactions, regulatory matters, corporate governance, compliance and intellectual property from 2000November 2015 to 2012July 2021. Prior to Seqirus, Mr. Minardo was with Novartis in increasing roles of increasing responsibility in manufacturingfrom October 2007 to November 2015, ultimately serving as vice president, general counsel and supply chain.chief compliance officer at Novartis Influenza Vaccines. Mr. Rickard beganMinardo started his legal career as a mechanical engineerlitigator at AMOT Controls Corporation.

Kaye Scholer LLP.


Mr. RickardMinardo holds an M.S.a B.A. from California State University—SacramentoBoston College and a B.S.J.D. from California State University—Chico, both in mechanical engineering.

Brooklyn Law School.

2021


2024 Proxy Statement   29


Table of Contents

GRAPHIC
31


[MISSING IMAGE: hr_greenltsm-4c.jpg]



MICHAEL

SHETZLINE,

M.D., Ph.D.

Senior Vice President, Chief Medical
Officer Senior Vice
President and Head of Research and
Drug
Development of Ironwood

Pharmaceuticals, Inc.

Age: 62

65

Joined Ironwood 2019


Dr. Shetzline has served as our chief medical officer, senior vice presidentand head of research and drug development since October 2021 and had served as chief medical officer, and head of drug development sincefrom January 2019.2019 to October 2021. Dr. Shetzline is a gastroenterologist and internist, with more than 2530 years of experience in the biopharmaceutical industry and academia.


Before joining Ironwood, Dr. Shetzline was vice president and head of gastroenterology clinical sciences at Takeda Pharmaceuticals International Co., or Takeda, a global pharmaceutical company, where he led global clinical development for all GI assets from January 2015 to January 2019.


Prior to Dr. Shetzline'sShetzline’s role at Takeda, Dr. Shetzline served as vice president and global head of gastroenterology at Ferring International Pharmascience Center U.S., Inc., or Ferring, from 2012 to January 2015, during which he led Ferring'sFerring’s clinical development programs in gastroenterology. Before that, Dr. Shetzline was vice president and global program head crossing multiple therapeutic areas and head of translational medicine GI discovery at Novartis Pharmaceuticals AG from 2002 to 2012.


Dr. Shetzline also served as gastroenterology program director and assistant professor of medicine at Duke University Medical Center from 1997 to 2002. Dr. Shetzline has published over 40 full papers and book chapters and acted as a reviewer for a range of medicine journals.


Dr. Shetzline earned his M.D. and Ph.D. from The Ohio State University in physiology and medicine. Dr. Shetzline completed his internal medicine residency and fellowship in gastroenterology and served on the faculty as a National Institutes of Health supported physician scientist at Duke University Medical Center.


Dr. Shetzline is a Fellow of the American College of Physicians, the American College of Gastroenterology, and the American Gastroenterological Association and certified by the American Board of Internal Medicine.

30    Ironwood


Table of Contents

GRAPHIC
32   Ironwood

[MISSING IMAGE: htr_greenorange-4c.jpg]
Executive Compensation

Compensation Discussion and Analysis

Executive Summary

Compensation Highlight: Performance-based Restricted Stock Units

Our executive equity compensation program continuedfor 2023 remained aligned with market practice and our corporate performance, which created a strong link between the value of our executives’ compensation and our stockholders’ returns. Together with the objective of linking executive and stockholder interests, our compensation program is also designed to evolveattract, retain, motivate and reward outstanding talent across Ironwood through well-communicated programs that are aligned with our vision and mission, and support a positive company culture and our values. The three primary elements of our executive officer compensation program are base salary, cash bonus and long-term equity incentive compensation. Long-term equity incentive compensation, which includes a balanced mix of time-based and performance-based equity awards, represents a significant percentage of each named executive officer’s target total direct compensation (as defined below). We believe this emphasis on equity strongly reinforces the concept of pay-for-performance, as the single largest component of pay is tied to execution of key performance milestones and future increases in 2020the value of our stock.

The majority of total direct compensation, which we define as base salary, target annual bonus and 2021. One key highlight is the addition of performance-based restricted stock units, or PSUs, granted totarget long-term equity incentive compensation, for our named executive officers.

In 2020, PSUs replaced stock optionsofficers during 2023 consisted of variable pay elements, as reported in the Summary Compensation Table included elsewhere in this proxy statement. We believe this allocation aligns with our 2020 executivepay-for-performance compensation program to further tie executive compensation to corporate performance and stockholder value. The PSUs awarded in March 2020 may be earned over a two to three-year performance period based on corporate achievement in three categories: (1) gaining the U.S. FDA acceptancephilosophy of one or more additional NDAs through internal development or acquisition of development-stage or commercial-stage programs, (2) achieving cumulative adjusted organic EBITDA goals, and (3) realizing specified levels of relative stockholder return, or rTSR.

In 2021, to further tie the compensation ofmotivating our named executive officers to stockholderachieve our performance objectives in the short term and to grow the business to create sustainable value for our compensation and HR committee determined to have an rTSR performance goal asshareholders in the sole PSU performance metric in our 2021 executive equity compensation program, as measured over a three-year performance period against an expanded peer group.

Additional information onlong term.

2023 CEO Compensation2023 Other NEOs Compensation
[MISSING IMAGE: pc_ceocompensation-4c.jpg]
[MISSING IMAGE: pc_neoscompensation-4c.jpg]
(*)
Performance-based awards for 2023 consisted of PSUs awarded to our named executive officers in 2020 and 2021 is provided under the respective captions 2020 Annual Equity Awards and 2021 Annual Equity Awards(as defined below), below.

which are valued at target.

Stockholder Engagement and Say-On-Pay Vote Consideration


2024 Proxy Statement   33

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Stockholder Engagement and Say-On-Pay Vote Consideration
Feedback from stockholders is an essential part of our executive compensation decision-making process. We value stockholders’ perspectives and have a regular process throughout the year to discuss a range of topics with our stockholders, including our strategy, operations, financial and business performance. Discussions with our stockholders assist us in setting goals and expectations for our performance and facilitate the identification of emerging issues that may affect our strategies, corporate governance, compensation practices, and other aspects of our operations. Our company engages with many of our largest stockholders on an annual basis.a frequent basis year-round. This includes investor conferences, investor events, and one-on-one discussions. We invite feedback on a wide variety of topics, including corporate strategy, capital allocation, governance, human capital management and executive compensation. In 2020, senior management met with the majority of Ironwood's largest 20 stockholders, which represented over 85% of our outstanding shares as of December 31, 2020. In addition, Alexander J. Denner, Ph.D., who is the chief investment officer of Sarissa Capital Management LP, one of our largest stockholders, joined our board in November 2020.

Our stockholders also have the opportunity to cast a non-binding advisory vote on named executive officer compensation, or a "say-on-pay"“say-on-pay” vote, every year. This allows our stockholders to provide us with regular, timely and direct input on our executive compensation philosophy, policies and practices. We believe this enables us to further align our compensation programs with our stockholders'stockholders’ interests and to enhance our ability to consider stockholder feedback as part of our annual compensation review process. We sought stockholder input on our executive compensation program through the say-on-pay vote at our 20202023 annual meeting of stockholders and approximately 84%98% of votes cast by our stockholders voted in support of our named executive officer compensation.

2021  Proxy Statement    31


Table of Contents

Named Executive Officers: Goals and Accomplishments
GRAPHIC

Named Executive Officers: Goals and Accomplishments

Named Executive Officers for 2020

2023

This section discusses the principles underlying our policies and decisions with respect to the compensation of our executive officers who are named in the Summary Compensation Table, or our named executive officers. Provided below are material factors we believe are relevant to an analysis of these policies and decisions. Our named executive officers for 20202023 were:

Mark Mallon, former
Thomas McCourt, chief executive officer;

Gina Consylman,
Sravan Emany, senior vice president, chief financial officer;

Andrew Davis, senior vice president, chief business officer;

John Minardo, senior vice president, chief legal officer and senior vice president;

secretary; and
Thomas McCourt, president and interim chief executive officer;

Jason Rickard, chief operating officer and senior vice president; and


Michael Shetzline, M.D., Ph.D., senior vice president, chief medical officer senior vice president and head of research and drug development.

Mr. Rickard and Dr. Shetzline became executive officers of Ironwood effective April 17, 2020. Effective March 12, 2021, Mr. Mallon resigned from his position as Ironwood's chief executive officer and Mr. McCourt became our interim chief executive officer in addition to his continued service as our president. For more information on our chief executive officer transition, please see Chief Executive Officer Transition elsewhere in this proxy statement.

Goals and Accomplishments

In late 2019,early 2023, our board, with input from senior management, established what it believed were challengingour 2023 corporate performance goals for 2020,and the relative weighting of such goals, the achievement of which we believed would further the accomplishment of our short- and long-term business plan. These goals included maximizing LINZESS net sales growth as well as the attainment of certain financial and pipeline targets, in each case, based on the Company'scompany’s board-approved operating plan for 2020. In early 2020,2023, as well as goals related to our compensationworkforce, strategy and HR committee approved the relative weighting of our corporate performance goals for 2020.

culture.

Our named executive officers (except Mr. Mallon) were evaluated based on the level of achievement of the 20202023 corporate goals and their achievements in 2020, including additionalagainst their 2023 individual goals that contributed toward, and related directly to, the accomplishment of the 2020 corporate goals. The compensation and HR committee and board determined to equate Mr. Mallon's individual performance with the company's overall corporate performance, and, as a result, assessed Mr. Mallon's performance based on the achievement of the 2020 corporate performance goals and accomplishments. Performance measured against the 20202023 corporate and individual goals (as applicable) was used, in part, in determining salary adjustments and cash bonus awards for our named executive officers in early 2021.

2024.

As described in more detail elsewhere in this proxy statement under Compensation Determination Process, beginning in 2021, our board becameis responsible for assessing the Company'scompany’s performance against its pre-determined corporate goals. Thus, inIn January 2021, 2024, our board determined that the 20202023 company performance achievement multiplier, which was used as a key consideration in determining executive compensation awarded for 20202023 performance, was 101%120%. When assessing corporate performance for 2020, our board noted that certain of our corporate goals for 2020 were met or exceeded despite the challenges posed by the COVID-19 pandemic. No COVID-19-related adjustments were made to goals, expectations or compensation targets for our named executive officers in 2020.

32    Ironwood


Table of Contents


GRAPHIC
34   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]

The level of achievement against our 20202023 corporate performance goals, as determined by our board in early 2021,2024, was as follows:

[MISSING IMAGE: bc_line-4c.jpg]
Company GoalPartially
Achieved
TargetOver
Achieved
Results
MAXIMIZE LINZESS (30%)
LINZESS U.S. Net Sales$1,022M$1,051M$>1,070M$1,073M(1)
Achieve U.S. FDA approval of sNDA for pediatric patients ages 6-17 years old with FCSpecific goals are not disclosed for
competitive reasons
Above Target(2)
Commercial launch target date of LINZESS for pediatric patients ages 6-17 years old with FC as measured by a launch scorecardSpecific goals are not disclosed for
competitive reasons
Above Target(3)
(20%)(30%)(40%)(40%)
BUILD INNOVATIVE PIPELINE (30%)
Secure 1 asset aligned with prioritized criteriaSpecific goals are not disclosed for
competitive reasons
Above Target(4)
Achieve CNP-104 enrollment targetSpecific goals are not disclosed for
competitive reasons
Target(5)
Achieve IW-3300 enrollment targetSpecific goals are not disclosed for
competitive reasons
Below Target(6)
(20%)(30%)(50%)(35%)
STRENGTHEN FINANCIAL PROFILE (35%)
Adjusted EBITDA from organic business (excluding the impact of any corporate development transactions and costs associated with a potential CNP-104 option exercise)$235M$250M$>260M$268M(7)
(30%)(35%)(40%)(40%)
CREATE GREAT PLACE TO WORK (5%)
Achieve a certain number of objectives on the corporate DEI scorecardCommittee judgment
on actual
performance
Specified NumberN/ATarget(8)
Maintain confidence in Ironwood’s strategy and culture, measured by positive response rate range on annual employee engagement surveyCommittee judgment
on actual
performance
>50%N/ATarget(9)
(5%)(5%)
TOTAL120%
Notes to 2023 Company Performance Targets and Results Table
Corporate
Goal
 Stockholder
Impact
 Achievements  Target
Percentage
(%)
  Actual Level of
Achievement
(%)
 
Drive LINZESS Growth Grows the revenue base 

Exceeded target U.S. LINZESS net sales of $892 million with compliance excellence

Obtained U.S. FDA approval of sNDA to include IBS-C overall abdominal symptoms data LINZESS label

  30% 40%
Advance our Pipeline Advances future business growth and profitability 

Obtained Phase III data from IW-3718 program and made data-driven "go/no go" decision to discontinue development of IW-3718

Obtained Phase II data from MD-7246 clinical trial ahead of schedule and made data-driven decision to discontinue development of MD-7246

  30% 30%
Expand our impact in GI Supports potential for long-term growth and profitability 

In connection with a U.S. disease education and promotional agreement with Alnylam Pharmaceuticals, Inc., Ironwood efforts contributed to >25 patients starting on GIVLAARI® (givosiran) treatment

  20% 6%
Invigorate Ironwood Helps to attract, motivate and retain top talent 

Built new GI capabilities and expertise

Strengthened and advanced equality, diversity & inclusion (ED&I) initiatives

  5% 5%
Strengthen our financial profile Enables Ironwood to invest thoughtfully without reliance on capital markets 

Exceeded target revenue of $372 million, target adjusted EBITDA* of $105 million, and target cash from operations of $135 million

Delivered 2nd full year of profitability

  15% 20%
    Totals  100% 101%
  Stretch Goals for Additional Potential Achievement  50% 0%
    TOTALS  150% 101%
(1)

* AdjustedGoal exceeded. LINZESS U.S. net sales were $1,073 million for the year ended December 31, 2023. LINZESS U.S. net sales are reported by our U.S. partner, AbbVie.

(2)
Goal exceeded. In June 2023, the U.S. FDA approved LINZESS as a once-daily treatment for pediatric patients ages 6-17 years old with functional constipation, making LINZESS the first and only FDA-approved prescription therapy for functional constipation in this patient population. Specific target thresholds are not disclosed for competitive reasons.
(3)
Goal exceeded. Specific details and target thresholds are not disclosed for competitive reasons.
(4)
Goal exceeded. In June 2023, we completed a tender offer to purchase 98% of the outstanding ordinary shares of VectivBio Holding AG. In December 2023, we completed a squeeze-out merger to acquire all remaining shares. Specific target thresholds are not disclosed for competitive reasons.
(5)
Goal achieved. Specific details and target thresholds are not disclosed for competitive reasons.
(6)
Goal was below target. Specific details and target thresholds are not disclosed for competitive reasons.
(7)
Goal exceeded. Our adjusted EBITDA, from continuing operationswhich was calculated by subtracting mark-to-market adjustments on derivatives related to Ironwood’s 2022 Convertible Notes, restructuring expenses, net interest expense, income taxes, depreciation and amortization, mark-to-market adjustments on derivatives related to Ironwood's 2.25% convertible notes due 2022, restructuring expenses,and acquisition-related costs, from GAAP net income, (loss)was ($884.8) million for the year ended December 31, 2023. When excluding from continuing operations.

adjusted EBITDA the impact of corporate development activities in 2023, which include all profit and loss incurred by VectivBio subsequent to the VectivBio acquisition, and the payment recognized in the second quarter of 2023 in connection with the amendment of the COUR Collaboration Agreement, our adjusted EBITDA from our organic business was $267.6 million for the year ended December 31, 2023.

2021

(8)
Goal achieved.
(9)
Goal achieved.

2024 Proxy Statement   33


Table of Contents

GRAPHIC 35

[MISSING IMAGE: hr_greenltsm-4c.jpg]

In support of the 20202023 corporate goals identified above, at the beginning of 2020 as well as throughout 2020 in response to changes in the business, Mr. Mallonour compensation and HR committee assigned ownership of a specific subset of individual goals tofor each of our named executive officers as follows:

described below.
[MISSING IMAGE: bc_line-4c.jpg]
Name
NameSummary of Individual Goals
Thomas McCourt

Board and Investor Relations: Engage with the board of directors to align strategic and operational objectives to optimize the value of the company. Engage with shareholders, analysts, and potential shareholders to convey the potential value of the company and associated risks and ultimately foster stock price growth.

Strategic Opportunities: Lead the assessment of strategic opportunities and champion efforts where appropriate to drive corporate value. Drive the successful integration of VectivBio into Ironwood to optimize value.

Operational Performance: Lead and motivate the business towards the accomplishment of the 2023 corporate goals established by the board of directors.

Talent & Leadership: Continue to strengthen the effectiveness of the executive leadership team, providing opportunities to advance their professional development and enhance team dynamics. Serve as the cultural champion of the organization.
Gina ConsylmanSravan Emany

Deliver target adjusted EBITDA from continuing operations

Generate cash from operations, requiring substantial

2023 Operating Plan: Champion achievement by collaborating with the commercial and brand teams to ensure proper investment in brand growth drivers and achievement of targeted LINZESS objectives. Drive fiscal management judgmentto ensure the attainment of financial goals.

Investor Relations: Engage with the board of directors, shareholders, analysts, and discipline, including efficient decision-making and cost-center level accountability across all aspectspotential shareholders to convey the potential value of the business

Evaluate inorganic opportunities in effort to drive further value including completing three GI deep divescompany and identifying a potential mid/late-stage asset

Lead corporate strategy,associated risks; ultimately foster stock price growth. Strengthen the investor relations and corporate communications activitiesmessaging and expand analyst coverage.


Corporate Development and Strategy: Collaborate with the Corporate Development function in assessing and negotiating potential transactions to gain alignmentenhance the value of the company. Advise management and the project team on a refreshed corporate strategy

financial opportunities and risks inherent in the transaction and mitigate those risks to the extent possible. Lead the efforts to negotiate and secure required financing to complete the transition.

VectivBio Integration: Lead the effort to sustain required functionalities without disruption, identify integration objectives, and achieve process and system synergies.

Finance Leadership: Oversee and develop the Finance function to ensure appropriate controls are in place over financial reporting and effective management of capital access and structure, and treasury operations.

IT and Facilities: Assume oversight of the Information Technology, or IT, and Facilities functions, including reassessing capabilities, risk, and investment to support operations and potential business development transactions.
Andrew Davis
Thomas McCourt

Deliver

Corporate Strategy: Lead efforts towards a well-defined and executed corporate strategy. Ensure the board of directors and company leadership are aligned on objectives. Continually evaluate potential alternatives and adaptations, factoring the degrees of success with various initiatives.

LINZESS net trade salesRevenue and total revenue targets

GrowLife-Cycle Management: Lead the valueCommercial and Brand functions to ensure delivery of IW-3718growth drivers, including achieving pre-determined sale targets. Expanding the commercial use of LINZESS with respect to pediatric patients ages 6-17 years old with FC.


Commercial Leadership: Strengthen leadership of the Commercial function, ensuring proactive ownership, communication, and engagement in refractory GERDgrowth strategies and advance MD-7246 IBS-D pain programtactics. Maintain and additional early-stage pipeline assets

Maximize the value delivered from our salesforce optimizing our GIVLAARI partnership with Alnylam Pharmaceuticals, Inc. and securing an additional commercial product

Establish one new innovative payer contract workingbuild a relationship with our commercialU.S. partner, for LINZESS, AbbVie, during 2020 in an effort to stabilize and ultimately improve net price

Build needed capabilities aimed at becoming the recognized leader in GI including optimizing our sales force, enhancing healthcare provider engagement, and certain talent upgrades

AbbVie.

36   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Name
Jason RickardSummary of Individual Goals

Lead the company's response to the COVID pandemic*

Facilitate the smooth transition of all linaclotide international supply responsibilities to AstraZeneca AB and Astellas Pharma Inc.

Execute operations relative to IW-3718 and MD-7246 programs including pharmaceutical development, supply chain and GxP quality

Further IT operational efficiencies including optimizing certain enterprise systems

Lead the company's reduction in force effort*

Deliver on our people priorities; inspire through our mission and strategy, advance our equality, diversity and inclusion program and grow/challenge our people with targeted individual development programs


Corporate Development Leadership: Lead the Corporate Development function in identifying, assessing, and closing on strategic initiatives to expand our product portfolio. Ensure proper prioritizing of opportunities, robust diligence and valuation work, negotiation of terms, and completion of transactions.

VectivBio Integration: Create and manage the framework to successfully integrate VectivBio into Ironwood, preserving the value and sustaining focus on progressing the apraglutide pipeline. Assume leadership for apraglutide’s commercial and distribution plans.
John Minardo

LINZESS Support: Effectively partner with the Commercial and R&D functions, as well as our U.S. partner, AbbVie, to support LINZESS, including advice on new consumer messaging and interactions with healthcare professionals on the new pediatric opportunity. Oversee our promotional review process and ensure compliance and timely review of the materials. Advise the business on the potential impacts and strategies to address potential generic challenges.

Corporate Risk Review: Partner with the board of directors and senior leadership to identify and mitigate organizational risks and minimize corporate exposure through effective legal counsel that balances or achieves business objectives and reduces opportunities for claims against Ironwood.

Corporate Development and Strategy: Lead the legal assessment of potential proposed transactions. Advise management and the project team on business risks inherent in the transaction, including intellectual property matters and mitigate risks to the extent possible through agreement negotiations and drafting. Lead the legal structuring and closing of transactions.

VectivBio Integration: Lead the effort to complete the public transaction of the acquired business. Improve the contracting process by incorporating VectivBio business to minimize disruption to the business. Build capabilities to support foreign operations.

Strengthen the leadership of the Legal team: Appropriately align and develop our legal capabilities in corporate governance, contracts, SEC filings, intellectual property, employee matters, public disclosures and corporate compliance.

DE&I Champion: Guide the DE&I Council, adding new perspectives to the dialogue. Co-lead the Reverse Mentorship Program and engage with our employee resource groups. Effectively advocate and promote the initiative to ensure the attainment of DE&I goals.
Michael Shetzline, M.D., Ph.D.

Gain

LINZESS Life-Cycle Management: Lead efforts to obtain regulatory approval of sNDAan expanded indication for pediatric patients ages 6-17 years old with FC in collaboration with our U.S. partner, AbbVie. Lead Data Sciences, Medical Affairs and our GI Insights Center to reflect resultsdeliver a publication plan to maximize the value of Phase IIIbour clinical trial in LINZESS label, negotiatingdata.

GI Pipeline Advancement: Expand our GI pipeline by advancing IW-3300 and securing additional languageCNP-104 studies. Identify potential life cycle management opportunities within the portfolio.

GI Pipeline Expansion: Collaborate with the U.S. FDA documentingCorporate Development function in identifying and assessing strategic initiatives to expand our product portfolio. Ensure proper prioritizing of opportunities and robust diligence from an R&D perspective.

VectivBio Integration and apraglutide program management: Identify and assimilate leadership to ensure the reliefsuccessful integration of overall abdominal symptomsVectivBio talent into the R&D function. Assess, prioritize, and manage sustained progress on apraglutide nonclinical, clinical, and chemistry, manufacturing, and controls (CMC) development, factoring life-cycle management considerations.

Strengthen leadership of IBS-Cthe R&D function: Develop talent in the LINZESS product label

Obtain IW-3718 top-line Phase III data in refractory GERD, implementing programs to accelerate screeningresearch and participant recruitment and gaining U.S. FDA consent to certain trial design changes to strengthen the overall program

Make go / no go decision on IW-3718 based on the clinical outcomes with a thorough assessment on strategic implications under various scenarios

Complete the data analysis and make go / no go decision on MD-7246 based on the clinical outcomes with a thorough assessment on strategic implications under various scenarios

Co-lead the GI landscape assessment to evaluate the existence and accessibility of GI assets across the industry, identifying and prioritizing potential assets

Establish a team of world classdrug development function as world-class experts and trusted opinion leaders in gastroenterology to provide valued insight and advice to the drug development and commercial teams

GI.

* Additional goal added during 2020 in response to changing business needs.

34    Ironwood


Table of Contents

GRAPHIC

In early 2021,2024, Mr. MallonMcCourt evaluated the individual performance in 20202023 of each of the named executive officers (other than himself) and provided feedback and made recommendations to our compensation and HR committee. The compensation and HR committee then determined the named executive officers'officers’ compensation, taking into account Ironwood's


2024 Proxy Statement   37

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Ironwood’s level of achievement of its 2023 corporate goals as determined by our board, and the fact that each named executive officer strongly metexceeded or exceededachieved performance expectations for 2020, as well as2023, and peer group and other market data from the competitive assessment undertaken by our compensation and HR committee'scommittee’s independent compensation consultant, Aon,Alpine Rewards, LLC, or Alpine, as discussed below.

Additional information on the basis for decisions about 20202024 compensation relating to our named executive officers is available throughout this section and elsewhere in this proxy statement under the captions Role of the Compensation and HR Committee and Role of the Compensation Consultant: Benchmarking and Peer Group Analysis.

Analysis.
Compensation Decisions for 2023

Compensation Decisions for 2020 and 2021

Named Executive Officer Compensation Program

As in prior years, the three primary elements of our executive compensation program arefor 2023 were base salary, cash bonus and long-term equity incentive compensation.

2023 Base Salary

Base salaries are determined at an executive'sexecutive’s commencement of employment and are generally re-evaluated annually and adjusted, if warranted, to realign salaries with market levels or in connection with promotions or other changes in role and to reflect the performance of the named executive officer. In determining whether to adjust or recommend an adjustment to a named executive officer'sofficer’s base salary, our compensation and HR committee takes into consideration factors such as our corporate performance in prior years, general economic factors and compensation parity among our named executive officers, as well as the abilities, performance and experience of the named executive officer. Our compensation and HR committee also reviews our named executive officers'officers’ past compensation at the company and market data. Beginning in 2021,In addition, our compensation and HR committee recommends, and our board approves, compensation determinations for our chief executive officer. Please see Role of the Compensation and HR Committee and Role of the Compensation Consultant: Benchmarking and Peer Group Analysis for further information.

In January 2020,February 2023, our compensation and HR committee reviewed and approved 2023 base salaries for 2020our named executive officers for 2023, except for Mr. Mallon, Ms. ConsylmanMcCourt whose base salary is reviewed and recommended by our compensation and HR committee and approved by the independent directors of our board of directors. In March 2023, following a recommendation by our compensation and HR committee, the independent directors of our board of directors approved Mr. McCourt.McCourt’s 2023 base salary. The increases in base salary for Mr. Mallon, Ms. ConsylmanMessrs. McCourt, Emany, Davis and Mr. McCourtMinardo and Dr. Shetzline were based on our compensation and HR committee's determination that we achieved 130%committee’s (and the board of our corporate goals in 2019 and,directors’, in the case of Ms. Consylman and Mr. McCourt, recognitionMcCourt) determination that each executive farofficer achieved or exceeded all or substantially all of her or his respective individual goals for 2019. These2022. In May 2023, the compensation and HR committee approved an additional increase to Mr. Emany’s 2023 base salary from $520,000 to $545,000 in recognition of the additional workload Mr. Emany would be assuming in connection with the elimination of the company’s chief operating officer role. The base salary determinations also took into account peer group and other market data from the Aon competitive assessment discussed below. In addition, the increase in base salary for Mr. McCourt in 2020 includes an adjustment to better align his base salary with the external market in his role as the company's president. In April 2020, the compensation and HR committee also ratified and approved 2020 base salaries for Mr. Rickard and Dr. Shetzline, in connection with their respective designation as executive officers of the company. In ratifying and approving Mr. Rickard and Dr. Shetzline's respective base salaries,conducted by Aon, our compensation consultant at the time, and HR committee considered a number of factors, including each of Mr. Rickard and Dr. Shetzline's backgrounds, the compensation paid to executivesdiscussed in similar positions at our peer group companies and other benchmark data, and executive compensation parity within Ironwood, as well as input from Aon.

2021  Proxy Statement    35


Table of Contents

GRAPHIC

more detail below. Base salary information for 20202023 compared to base salary information for 2019 for our named executive officers, as applicable, is as follows:

Named Executive Officer

2019
Base Salary
2020
Base Salary
Increase ($)Increase (%)

Mark Mallon

$750,000$772,500$22,5003%

Gina Consylman

$480,000$494,400$14,4003%

Thomas McCourt

$520,000$556,400$36,4007%

Jason Rickard

*$456,750**

Michael Shetzline, M.D., Ph.D.

*$448,050**

* Mr. Rickard and Dr. Shetzline became executive officers of Ironwood effective April 17, 2020.

In February 2021, our compensation and HR committee reviewed and approved base salaries for our named executive officers for 2021. Base salary information for 2021 compared to base salary information for 20202022 for each of our named executive officers is as follows:

[MISSING IMAGE: bc_line-4c.jpg]
Named Executive Officer2022
Base Salary
2023
Base Salary
Increase ($)Increase (%)
Thomas McCourt$806,000$834,210$28,2103.5%
Sravan Emany$500,000$545,000(1)$45,0009.0%
Andrew Davis$460,000$480,000$20,0004.3%
John Minardo$494,000$512,728$18,7283.8%
Michael Shetzline, M.D., Ph.D.$513,040$533,562$20,5224.0%

Named Executive Officer

2020
Base Salary
2021
Base Salary
Increase ($)Increase (%)

Gina Consylman

$494,400$509,400$15,0003%

Thomas McCourt

$556,400$573,200$16,8003%

Jason Rickard

$456,750$484,200$27,4506%

Michael Shetzline, M.D., Ph.D.

$448,050$484,000$35,9498%
(1)

The

In May 2023, the compensation and HR committee did not recommend, and the board did notapproved an additional increase to Mr. Mallon'sEmany’s 2023 base salary from $520,000 to $545,000 in 2021 becauserecognition of the additional workload Mr. Mallon had provided noticeEmany would be assuming in connection with the elimination of his intent to resign from the company at the time salary determinationscompany’s chief operating officer role.

38   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Annual Cash Incentive Program for 2021 were made. Information on Mr. McCourt's salary for his service as our interim chief executive officer beginning in March 2021 is available elsewhere in this proxy statement under the caption Chief Executive Officer Transition.

Cash Bonus

2023 Performance

Our annual cash incentive program, or ACIP or cash bonus programaward, is designed to reward the achievement of our annual corporate goals and individual goals. The program is also intended to foster and support our performance-driven culture by setting clear, high-value goals, rewarding outstanding performers and making sure our employees know clearly that we value their contributions. Each target bonus award, expressed as a percentage of an executive'sexecutive’s base salary, is determined annually and is based on the extent to which we achieved our corporate goals for the preceding year, as well as the executive'sexecutive’s individual performance in that year against his or her individual goals. In 2020, Mr. Mallon's targetgoals as well as peer group and other market data. Target bonus was 75%percentages for 2023 for each of his base salary, Ms. Consylman's target bonus was 50% of her base salary, and Mr. McCourt's target bonus was 60% of his base salary. Upon their designation asour named executive officers, in April 2020,which were unchanged from the compensation and HR committee ratified and approved Mr. Rickard and Dr. Shetzline'srespective target bonus percentages for 2020, which for Mr. Rickard was 50% of his base salary and for Dr. Shetzline was 40% of his base salary. 2022, are as follows:
[MISSING IMAGE: bc_line-4c.jpg]
Named Executive Officer2023 Target Bonus
(as a % of base salary)
Thomas McCourt75%
Sravan Emany50%
Andrew Davis50%
John Minardo45%
Michael Shetzline, M.D., Ph.D.45%
We believe that these target bonus percentages align the target total cash compensation, as defined below, of our named executive officers with that of our peers, place appropriate emphasis on the achievement of our annual performance objectives and facilitate recruiting, retaining, and motivating our executive officers.

36    Ironwood


Table of Contents

GRAPHIC

For each of our named executive officers, other than our chief executive officer, 70% of each 2023 cash bonus award paid in 2021 for 2020 performance was based solely on the achievement of our corporate goals and 30% was based on the named executive officer'sofficer’s achievement of his or her individual goals which, as described above, for named executive officers other than Mr. Mallon, included specific accountability for certain ofand our corporate goals. In recommending for approval by the board the amount of Mr. Mallon'sMcCourt’s 2023 cash bonus, to be paid in 2021 for 2020 performance, our compensation and HR committee equateddetermined to set Mr. Mallon'sMcCourt’s individual performance in 2023 to be equal to the company's 2020company’s performance achievement multiplierfactor of 101%120%. The board reviewed and followed this recommendation in approving Mr. Mallon'sMcCourt’s cash bonus award for 2020 performance, which he remained eligible to receive as a result of being employed as our chief executive officer on the date cash bonus awards for 2020 performance were paid in 2021.

2023 performance.

The following table summarizes the calculation of our named executive officers'officers’ cash bonus awards, paid in 2021other than for 2020 performance:

our chief executive officer. Mr. McCourt’s 2023 cash bonus was calculated by multiplying his target bonus percentage (75%) by the corporate performance factor, as noted above.
[MISSING IMAGE: bc_line-4c.jpg]
Component Calculation
Company Performance
Only Component
(Weighted 70%)
70% Weighting×
Component Calculation
Company Performance
Only Component
(Weighted 70%)
70% Weighting×Target Bonus×Corporate Performance

Achievement Multiplier
=Company
Performance

Only Component
Payout
+
Company and Individual
Performance Component
(Weighted 30%)


30% Weighting×Target Bonus×Corporate
Performance
Achievement
Multiplier



×Individual
Performance
Achievement
Multiplier



=Company and
Individual Performance
Component Payout
+
Company and Individual
Performance
Component
(Weighted 30%)
30% Weighting×Target Bonus×Corporate
Performance
Achievement
Multiplier
Total Annual
Bonus
×Individual
Performance
Achievement
Multiplier
=Company and Individual
Performance
Component
Payout
Total Annual
Bonus Payout

This approach was intended to closely align cash bonus award payouts with the achievement of our corporate goals, while taking into account individual performance (or, in the case of Mr. Mallon,McCourt, equating company performance with

2024 Proxy Statement   39

[MISSING IMAGE: hr_greenltsm-4c.jpg]
individual performance) and making bonus determinations in a transparent way. As described above, the company performance achievement multiplier for 20202023 was 101%120%. In February 2021,2024, our compensation and HR committee, determined that each of our named executive officers other(other than Mr. Mallon, strongly metMcCourt, whose individual performance was equated with company performance) achieved or exceeded performance expectationspre-established individual goals for 2020,2023, resulting in the following individual performance achievement multipliers and bonus ratios to target bonus percentage (after applying the 70%/30% weighting and taking into account the company performance achievement multiplier of 101%120%): Ms. Consylman, 120% individual performance, resulting.The compensation and HR committee then reviewed and approved (or, in actual bonus to target bonus ratiothe case of 107%; Mr. McCourt, 120% individualrecommended that the board approve, which recommendation was followed by the board) the following bonuses for 2023 performance resulting in actual bonus to target bonus ratio of 107%; Mr. Rickard, 140% individual performance, resulting in actual bonus to target bonus ratio of 113%; and Dr. Shetzline, 125% individual performance, resulting in actual bonus to target bonus ratio of 109%. for our named executive officers:
[MISSING IMAGE: bc_line-4c.jpg]
Named Executive OfficerIndividual PerformanceActual Bonus to Target Bonus
Ratio
Annual Cash Incentive Program
for 2023 Performance
Thomas McCourt120%(1)120%$750,780
Sravan Emany135%133%$361,335
Andrew Davis140%134%$322,560
John Minardo110%124%$284,929
Michael Shetzline, M.D., Ph.D.125%129%$309,733
(1)
As described above, our compensation and HR committee also recommended, and our board determined that Mr. Mallon'sMcCourt’s individual performance achievement multiplier was 101%120% on the basis that such multiplier was equal to the corporate performance achievement multiplier of 101%120%. The compensation and HR committee (or the board, in the case of Mr. Mallon) reviewed and approved the following bonuses for 2020 performance for our named executive officers:

Named Executive Officer

Annual Cash Bonus
for 2020 Performance

Mark Mallon

$585,169

Gina Consylman

$264,652

Thomas McCourt

$357,409

Jason Rickard

$258,338

Michael Shetzline, M.D., Ph.D.

$194,588

2021  Proxy Statement    37


Table of Contents

GRAPHIC

In addition to the annual cash bonus for 2020 performance described above, in January 2020, Dr. Shetzline received a payment of $100,000, reflecting the second installment of his sign-on bonus under the terms of his employment offer letter.

2023 Long-Term Equity Awards

Long-term equity incentive compensation granted in 20202023 represented, on average, approximately 70% of each named executive officer'sofficer’s total compensation for the year (based on the grant date fair value of equity awards, with performance-based restricted stock unit, or PSU, awards measured at target). We believe this emphasis on equity, and particularly performance-based equity, strongly reinforces the principle of "pay“pay for performance",performance” and closely ties our executives'executives’ pay outcomes to stockholder value creation. We also use equity awards as our incentive vehicle for long-term compensation to attract, reward and retain our named executive officers and to align the interests of our named executive officers with those of stockholders. We typically grant equity awards in the first quarter of each year based on our performance in the prior year.
Throughout the year, our compensation and HR committee may award additional equity grants as circumstances warrant. Our compensation and HR committee does not apply a rigid formula in allocating equity awards to our named executive officers as a group or to any particular named executive officer, but setsfor 2023 set an equity pool each year based on peer group and other market data from the Aona competitive assessment prepared by its compensation consultant as discussed below. In addition to peer group and market data, our compensation and HR committee also considers other factors, including input from Aonits compensation consultant and the amount of unvested equity held by a named executive officer, in determining the size of individual equity awards.

    2020

2023 Annual Equity Awards

In 2020, our compensation and HR committee decided to introduce PSUs into our 2020 executive equity compensation program in an effort drive accountability to achieve key milestones and deliver stockholder returns. In introducing PSUs in 2020 and providing for an equal number of PSUs and RSUs to our named executive officers,early 2023, the compensation and HR committee sought to design a 2020 executive equity compensation program that provides the appropriate combination of equity awards to incentivize performance, align executive interests with those of our stockholders, and encourage executive retention.

To facilitate the transition in 2020 from the use of stock options, which vested on a monthly basis, to PSUs, which were subject to two or three year performance periods, 2020 RSU grants to our named executive officers vest as to approximately 33% of the underlying shares on each approximate anniversary of the grant date of the award. Performance goals underlying 2020 PSU awards must be achieved over a two to three-year performance period based, in part, on our long-range operating plan. Our compensation and HR committee selected the following performance goals for our 2020 PSU awards, which were intended to drive executive accountability for delivering value to our stockholders:

1)
Gaining the U.S. FDA's acceptance of one or more additional NDAs through internal development or acquisition of development-stage or commercial-stage programs, or NDA Acceptance PSUs;

2)
Growing revenue and controlling expenses as measured by cumulative adjusted organic EBITDA, or Adjusted EBITDA PSUs; and

3)
Realizing rTSR goals, or 2020 rTSR PSUs.

38    Ironwood


Table of Contents

GRAPHIC

The 2020 PSUs use the following metrics, weighting and vesting opportunity:

Performance MetricWeightPerformance PeriodThreshold Goals
(50% attainment)
Target Goals
(100% attainment)
Stretch Goals
(200% attainment)
NDA Acceptance PSUs40%Ending December 2022N/AAcceptance by the U.S. FDA of an NDA for IW-3718 or other internal or external development programAcceptance by the U.S. FDA of two NDAs, including IW-3718 and/or other internal or external development programs
Adjusted EBITDA PSUs30%2020 - 2021
Cumulative Target
Threshold cumulative adjusted organic EBITDA through 2021Target cumulative adjusted organic EBITDA through 2021Stretch target cumulative adjusted organic EBITDA through 2021
2020 rTSR PSUs30%Ending December 2022rTSR at the 25th percentile compared to rTSR peer group through 2022rTSR at the 50th percentile compared to rTSR peer group through 2022rTSR at the 75th percentile compared to rTSR peer group through 2022

Our compensation consultant, Aon, assisted our compensation and HR committee with assessing our profile and market characteristics versus several potential benchmarks and then identifying a peer group of commercial pharmaceutical and biotechnology companies for purposes of the 2020 rTSR PSUs. At the time they were designated, the peer group identified for the purposes of the 2020 rTSR PSUs ranged between $750 million and $10 billion in market capitalization; Ironwood's market capitalization at that time was at the 47th percentile relative to this custom peer group. Our compensation and HR committee then approved the following custom rTSR measurement peer group for the 2020 rTSR PSUs, which included all of our executive compensation peers at the time the custom rTSR peer group was designated:

2021  Proxy Statement    39


Table of Contents

GRAPHIC
ACADIA Pharmaceuticals, Inc.Ionis Pharmaceuticals, Inc.
Aerie Pharmaceuticals, Inc.Jazz Pharmaceuticals plc
Agios Pharmaceuticals, Inc.Karyopharm Therapeutics Inc.
Akcea Therapeutics, Inc.Ligand Pharmaceuticals Incorporated
Akebia Therapeutics, Inc.Momenta Pharmaceuticals, Inc.
Alkermes plcOPKO Health, Inc.
Amicus Therapeutics, Inc.Pacira BioSciences, Inc.
Amphastar Pharmaceuticals, Inc.Perrigo Company plc
bluebird bio, Inc.Portola Pharmaceuticals, Inc.
Blueprint Medicines CorporationPrestige Consumer Healthcare Inc.
Catalent, Inc.PTC Therapeutics, Inc.
Coherus BioSciences, Inc.Radius Health, Inc.
Corcept Therapeutics IncorporatedSage Therapeutics, Inc.
Eagle Pharmaceuticals, Inc.Sarepta Therapeutics, Inc.
Emergent BioSolutions Inc.Spectrum Pharmaceuticals, Inc.
Endo International plcSupernus Pharmaceuticals, Inc.
Exelixis, Inc.Taro Pharmaceutical Industries Ltd.
Flexion Therapeutics, Inc.Theravance Biopharma, Inc.
GW Pharmaceuticals plcUltragenyx Pharmaceutical Inc.
Halozyme Therapeutics, Inc.United Therapeutics Corporation
Heron Therapeutics, Inc.Vanda Pharmaceuticals Inc.
Horizon Therapeutics Public Limited CompanyVeracyte, Inc.
Insmed IncorporatedVericel Corporation
Intercept Pharmaceuticals, Inc.

40    Ironwood


Table of Contents

GRAPHIC

In 2020, our named executive officers were granted the following equity awards under our 2019 Plan:

Named Executive Officer

2020 Annual PSU Grant
(# of Shares of Class A common stock
Subject to PSUs) (at target)
2020 Annual RSU Grant
(# of Shares of Class A common stock
Subject to RSUs)

Mark Mallon

221,061221,061

Gina Consylman

68,32768,327

Thomas McCourt

100,482100,482

Jason Rickard

60,28960,289

Michael Shetzline, M.D., Ph.D.

48,875*48,875*

* Comprised of 28,135 PSUs and 28,135 RSUs granted in February 2020, as well as an additional 20,740 PSUs and 20,740 RSUs granted in April 2020 in connection with Dr. Shetzline's designation as an executive officer of the company. The compensation and HR committee approved this additional award based on Aon's input and in order to further align Dr. Shetzline's unvested equity position with that of the other executive officers. The PSUs and RSUs granted to Dr. Shetzline in April 2020 were subject to the same terms as described above related to equity grants to named executive officers in 2020.

In connection with their designation as executive officers of the company in April 2020, the compensation and HR committee ratified and approved the PSU and RSU grants listed above for Mr. Rickard and Dr. Shetzline.

As of the date of this proxy statement, none of the PSUs granted in 2020 had vested.

    2021 Annual Equity Awards

In early 2021, our compensation and HR committee again determined as it had in 2020, that the annual long-term equity incentive compensation awards for our named executive officers should consist of an approximately even number of PSUs and RSUs. TheFor PSUs, the compensation and HR committee chosefurther determined that performance under our PSU awards should be measured against total shareholder return, or TSR, using absolute TSR (50%), or aTSR, and relative TSR (50%), or rTSR, performance as the sole PSU performance metricmetrics in our 2021 executive equity compensation programorder to tie further tie the compensation of our named executive officers to stockholder value. Aon assisted thevalue creation and hold our executives accountable for our stock price performance. The compensation and HR committee with identifying a peer group specificallyfurther determined that the three-year performance period for purposes of the rTSR measurement goal related2023 PSUs should start on March 1, 2023 and end on February 28, 2026. This change to how the performance period is measured (relative to PSUs granted in 2021,prior years, in which the performance period aligned with the calendar year) will enable both performance metrics to take into account current financial information through the most recent fiscal year-end, as well as any changes in


40   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
financial guidance that may have affected the stock price of the company and the rTSR peer group companies throughout the performance period.
The 2023 PSUs use the following metrics, weighting and vesting opportunity:
[MISSING IMAGE: bc_line-4c.jpg]
Performance
Metric
WeightPerformance
Period
ThresholdTargetAbove TargetMaximum
2023 aTSR PSUs50%Three years ending February 28, 202650%
attainment:

30 calendar-day average closing share price of $13.23 or above
100% attainment:
30 calendar-day average closing share price of $13.80 or above
200% attainment:
30 calendar-day average closing share price of $15.53 or above
400% attainment:
30 calendar-day average closing share price of $17.25 or above
2023 rTSR PSUs(1)50%Three years ending February 28, 202650%
attainment:

rTSR at the 25th percentile compared to rTSR peer group through February 2026
100% attainment:
rTSR at the 50th percentile compared to rTSR peer group through February 2026
N/A200% attainment:
rTSR at the 75th percentile compared to rTSR peer group through February 2026
(1)
If the TSR percentile rank falls between Threshold, Target or Maximum goals, the 2021percentage of rTSR PSUs which group differed from the peer group selectedearned shall be interpolated on a straight-line basis. Attainment for the 20202023 rTSR PSUs. PSUs is capped at 100% where the company’s TSR is negative.
At the time they were designated, the peer group identifiedcompanies selected for the purposes of the 20212023 rTSR PSUs consisted of commercial pharmaceutical and biotechnology companies that ranged between $750 million and $10 billion in market capitalization; Ironwood'sIronwood’s 30-day market value capitalization at that timeas of December 31, 2022, was at the 3947th percentile relative to this custom peer group. Our compensation and HR committee then approved the following custom rTSR measurement peer group for the 20212023 rTSR PSUs, which included all of our executive compensation peers with the exceptions of Akcea Therapeutics, Inc., which was acquired, and Horizon Therapeutics plc, which had exceeded the market capitalization range at the time the 2021 rTSR PSU peer group was designated:

2021peers:


2024 Proxy Statement   41


Table of Contents

GRAPHIC


[MISSING IMAGE: hr_greenltsm-4c.jpg]
[MISSING IMAGE: bc_line-4c.jpg]
ACADIA Pharmaceuticals, Inc. (Nasdaq: ACAD)Jazz Pharmaceuticals plcInsmed, Inc. (Nasdaq: INSM)
Acceleron PharmaADMA Biologics (Nasdaq: ADMA)Intercept Pharmaceuticals, Inc. (Nasdaq: ICPT)
KaryopharmAlkermes plc (Nasdaq: ALKS)Ionis Pharmaceuticals, Inc. (Nasdaq: IONS)
Amicus Therapeutics, Inc. (Nasdaq: FOLD)Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA)
AgiosApellis Pharmaceuticals, Inc. (Nasdaq: APLS)Kronos Bio, Inc.
Alkermes plcLigand Pharmaceuticals Incorporated (Nasdaq: LGND)
Amarin Corporation plcArcus Biosciences, Inc. (Nasdaq: RCUS)MannKind CorporationMyriad Genetics, Inc. (Nasdaq: MYGN)
Amicus Therapeutics,Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR)MiMedx Group,Natera, Inc. (Nasdaq: NTRA)
AmphastarAvid Bioservices, Inc. (Nasdaq: CDMO)Novavax, Inc. (Nasdaq: NVAX)
BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX)Neurocrine Biosciences,Organogenesis Holdings Inc. (Nasdaq: ORGO)
Biohaven Pharmaceutical Holding Company Ltd.Ocular Therapeutix, Inc.
bluebird bio, Inc.Omeros Corporation
Blueprint Medicines Corporation (Nasdaq: BPMC)OPKO Health, Inc.
Coherus BioSciences, Inc.Pacira BioSciences, Inc. (Nasdaq: PCRX)
Corcept Therapeutics IncorporatedPerrigo Company plc
DecipheraCatalyst Pharmaceuticals, Inc. (Nasdaq: CPRX)Prestige Consumer Healthcare Inc.
Emergent BioSolutions Inc.PTC Therapeutics, Inc. (Nasdaq: PTCT)
Endo International plcCoherus BioSciences, Inc. (Nasdaq: CHRS)Radius Health,REGENXBIO Inc. (Nasdaq: RGNX)
Epizyme, Inc.Corcept Therapeutics Incorporated (Nasdaq: CORT)Revance Therapeutics, Inc.
Esperion Therapeutics, Inc.Sage Therapeutics, Inc.
Exelixis, Inc.Sorrento Therapeutics, Inc.
Global Blood Therapeutics, Inc.Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN)
GWCytokinetics, Inc. (Nasdaq: CYTK)Syndax Pharmaceuticals, plcInc. (Nasdaq: SNDX)Taro Pharmaceutical Industries Ltd.
Deciphera Pharmaceuticals (Nasdaq: DCPH)Travere Therapeutics, Inc. (Nasdaq: TVTX)
Denali Therapeutics, Inc. (Nasdaq: DNLI)Vanda Pharmaceuticals Inc. (Nasdaq: VNDA)
Dynavax Technologies Corporation (Nasdaq: DVAX)Veracyte, Inc. (Nasdaq: VCYT)
Exact Sciences Corporation (Nasdaq: EXAS)Vericel Corporation (Nasdaq: VCEL)
Exelixis, Inc. (Nasdaq: EXEL)Vir Biotechnology, Inc. (Nasdaq: VIR)
FibroGen, Inc. (Nasdaq: FGEN)Xencor Inc. (Nasdaq: XNCR)
Halozyme Therapeutics, Inc. (Nasdaq: HALO)Theravance Biopharma, Inc.
Harmony Biosciences Holdings, Inc.United Therapeutics Corporation
Heron Therapeutics, Inc.Veracyte, Inc.
Insmed IncorporatedVericel Corporation
Intercept Pharmaceuticals, Inc.Viela Bio, Inc.
Ionis Pharmaceuticals, Inc.Zogenix, Inc.

In February 2021,March 2023, our named executive officers (other than Mr. Mallon) were granted RSUs and in March 2021, our named executive officers (other than Mr. Mallon) were granted PSUs, in each case under our 2019 Plan. Unlike the RSUs granted in 2020, which vest in equal installments over three years to facilitate a transition in 2020 away from stock options that vested on a monthly basis, RSUs granted in 20212023, other than for our chief executive officer, vest as to approximately 25% of the underlying shares on each approximate anniversary of the grant date of the award, subject to continued employment on each vesting date, which is the vesting schedule typically used for RSU awards granted to employees. RSUs granted in 2023 to Mr. McCourt vest as to 33.3% of the underlying shares on each approximate anniversary of the grant date of the award, subject to his continued employment on each vesting date. As stated previously,described above, the 20212023 PSU awards are subject to a singleaTSR and rTSR performance goal, which isgoals, and are measured over a three-year performance period ending December 31, 2023.

February 28, 2026.


42   Ironwood


Table of Contents

GRAPHIC

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]

The RSURSUs and PSUs granted to our named executive officers (other than Mr. Mallon) in February and March of 2021, respectively,2023 were as follows:

[MISSING IMAGE: bc_line-4c.jpg]
Named Executive Officer2023 Annual PSU Grant
(# of Shares of Class A common stock
Subject to PSUs) (at target)
2023 Annual RSU Grant
(# of Shares of Class A common stock
Subject to RSUs)
Thomas McCourt240,594240,595
Sravan Emany74,23574,236
Andrew Davis74,32574,236
John Minardo65,50265,502
Michael Shetzline, M.D., Ph.D. 69,869 69,869

Named Executive Officer

  2021 Annual PSU Grant
(# of Shares of Class A common stock
Subject to PSUs) (at target)
  2021 Annual RSU Grant
(# of Shares of Class A common stock
Subject to RSUs)
 

Gina Consylman

 84,541 84,951 

Thomas McCourt

  144,927  145,631 

Jason Rickard

 84,541 84,951 

Michael Shetzline, M.D., Ph.D.

  57,971  58,252 

In making its determinations with respect to the size of the equity awards awardedgranted to each of our named executive officers, our compensation and HR committee took into account peer group and other market data from the Aon competitive assessment discussed below, as well as other factors including each executive'sexecutive’s current equity holdings, expected future contributions and retention. Mr. Mallon did not receive

In February and March 2024, our compensation and HR committee certified that, with respect to the 2023 aTSR PSUs, the achievement of the “threshold” and “target” company share price targets, as specified in the 2023 PSUs metrics table above, were satisfied, resulting in 50% and 100% attainment, respectively, of the 2023 aTSR PSUs performance metric. Additional 2023 aTSR PSUs may vest upon the achievement of the additional stock price vesting targets specified above during the performance period ending February 28, 2026.
2021 rTSR PSUs Payout
In early 2021, our compensation and HR committee chose rTSR performance as the sole PSU performance metric in our 2021 executive equity awardscompensation program to further tie the compensation of our named executive officers to stockholder value, as described in our 2022 proxy statement filed with the SEC on April 21, 2022.
The 2021 because herTSR PSUs had provided noticethe following metrics and vesting opportunities:
[MISSING IMAGE: bc_line-4c.jpg]
Performance MetricPerformance PeriodThreshold Goals
(50% attainment)
Target Goals
(100% attainment)
Stretch Goals
(200% attainment)
2021 rTSR PSUsThree years
ending
December 31, 2023
rTSR at the 25th percentile compared to rTSR peer group through 2023rTSR at the 50th percentile compared to rTSR peer group through 2023rTSR at the 75th percentile compared to rTSR peer group through 2023(1)
(1)
Attainment for the 2021 rTSR PSUs is capped at 100% where the company’s TSR is negative.
In January 2024, our compensation and HR committee certified that, with respect to the 2021 rTSR PSUs, the achievement of his intentthe rTSR percentile rank compared to resign from the company atrTSR peer group for the time annual equity awards were granted.

performance period, which ended on December 31, 2023, was 72%, resulting in a 100% attainment of this performance metric, since the company’s total stockholder return was negative over the three-year performance period.

Executive Severance Agreements and Benefits in the Event of a Change of Control

The severance arrangements that we have with our named executive officers, as well as other benefits provided in the event of a change of control, are described elsewhere in this proxy statement under the captions Named Executive Officer Severance Arrangements and Benefits in the Event of a Change of Control and Potential Payments Upon Termination or Change of Control. Severance benefits are only payable if the named executive officer has complied with all of our rules and policies, has executed a separation agreement that includes a release of claims and complies with his or her post-employment nondisclosure, noncompetition and non-solicitation obligations. We believe that

2024 Proxy Statement   43

[MISSING IMAGE: hr_greenltsm-4c.jpg]
offering these payments and benefits assists us in recruiting, retaining and motivating executive officers, facilitates the operation of our business, allows our named executive officers to better focus their time, attention and capabilities on our business, and provides for a clear and consistent approach to managing departures with mutually understood separation benefits.

Other Compensation

We maintain broad-based benefits, including health insurance, life and disability insurance, dental insurance, fitnessremote work and transportationwell-being stipends, commuter subsidies (for employees who reside in Massachusetts and neighboring states), and a 401(k) plan with a 75% matching company contribution equal to the greater of: (a) 100% of employee contributions on the first $8,0003% of an employee's annual contribution, which are provided to all employees.

We also maintain a relocation program under which we make certain benefits available to newly hiredeligible compensation and existing employees, including our named executive officers, who are relocating to accept a new position with50% of employee contributions on the company. Our relocation program covers reasonable expenses associated withnext 3% of eligible compensation; or (b) 75% of the move and certain relocation services, including, as applicable, temporary housing assistance payments and a lump-sum relocation allowance, departure home sale assistance, rental assistance, new home search assistance, home purchase assistance, movingfirst $10,000 of household goods and vehicles assistance, and reimbursement of final trip expenses to the new area. We also provide tax assistance to our relocating employees to cover the costs associated with certain non-deductible relocation expenses, as we believe that this benefit is important to our ability to attract employees. Under our relocation program, participants are required to pay back the full amount of all relocation reimbursements in the event that they voluntarily terminate their employment or are terminated for "cause" within specified repayment periods.

2021  Proxy Statement    43


Table of Contents

GRAPHIC employee contributions.

Other than our broad-based benefits, or as otherwise described herein, none of our named executive officers receive perquisites of any nature.

Chief Executive Officer Transition

Effective

Compensation Decisions for 2024
2024 Base Salary
In February 2024, our compensation and HR committee reviewed and approved 2024 base salaries for our named executive officers, except for Mr. McCourt, whose base salary is reviewed and recommended by our compensation and HR committee and approved by the independent directors of our board of directors. In March 12, 2021, Mr. Mallon resigned from his position as2024, following a recommendation by our chief executive officercompensation and a memberHR committee, the independent directors of our board of directors to pursue another opportunity.approved Mr. Mallon did not receive severanceMcCourt’s base salary. The increases in connection withbase salary for our named executive officers were based on our compensation and HR committee’s (and the terminationboard of directors’, in the case of Mr. McCourt) determination that each executive officer achieved or exceeded substantially all of his employment. respective individual goals for 2023. These base salary determinations also took into account peer group and other market data from the competitive assessment conducted by Alpine and discussed in more detail below. Base salary information for 2024 compared to base salary information for 2023 for each of our named executive officers, is as follows:
[MISSING IMAGE: bc_line-4c.jpg]
Named Executive Officer2023
Base Salary
2024
Base Salary
Increase ($)Increase (%)
Thomas McCourt$834,210$867,568$33,3584.0%
Sravan Emany$545,000$569,525$24,5254.5%
Andrew Davis$480,000$510,000$30,0006.3%
John Minardo$512,728$531,745$19,0173.7%
Michael Shetzline, M.D., Ph.D.$533,562$557,572$24,0104.5%
2024 Annual Equity Awards
In addition, Mr. Mallon forfeited 282,231 options, 354,796 RSUsearly February 2024, the compensation and 221,061HR committee again determined that the annual long-term equity incentive compensation awards for our named executive officers should consist of an approximately even number of PSUs and RSUs. For PSUs, the compensation and HR committee further determined that performance under our PSU awards should again be measured against both an aTSR (50%) and an rTSR performance metric (50%) in connection with his resignation.

order to continue to tie the compensation of our named executive officers to stockholder value creation and hold our executives accountable for our stock price performance. The compensation and HR committee further determined that the three-year performance period for the 2024 PSUs should start on March 1, 2024 and end on February 28, 2027, similar to the approach it took in 2023. This approach will enable both performance metrics to take into account current financial


44   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
information through the most recent fiscal year-end, as well as any changes in financial guidance that may have affected the stock price of the company and the rTSR peer group companies throughout the performance period.
The 2024 PSUs use the following metrics, weighting and vesting opportunity:
[MISSING IMAGE: bc_line-4c.jpg]
Performance
Metric
WeightPerformance
Period
ThresholdTargetAbove TargetMaximum
2024 aTSR
PSUs
50%Three years ending February 28, 202750% attainment:
30 calendar-day average closing share price of $16.38 or above
100% attainment:
30 calendar-day average closing share price of $17.09 or above
200% attainment:
30 calendar-day average closing share price of $19.22 or above
400% attainment:
30 calendar-day average closing share price of $21.36 or above
2024 rTSR
PSUs(1)
50%Three years ending February 28, 202750% attainment:
rTSR at the 25th percentile compared to rTSR peer group through February 2027
100% attainment:
rTSR at the 50th percentile compared to rTSR peer group through February 2027
N/A200% attainment:
rTSR at the 75th percentile compared to rTSR peer group through February 2027
(1)
If the TSR percentile rank falls between Threshold, Target or Maximum goals, the percentage of rTSR PSUs earned shall be interpolated on a straight-line basis. Attainment for the 2024 rTSR PSUs is capped at 100% where the company’s TSR is negative.
At the time they were designated, the peer group companies selected for the 2024 rTSR PSUs consisted of commercial pharmaceutical and biotechnology companies that ranged between $500 million and $15 billion in market capitalization; Ironwood’s 30-day average market value capitalization as of December 31, 2023 was at the 44th percentile relative to this custom peer group. Our compensation and HR committee approved the following custom rTSR measurement peer group for the 2024 rTSR PSUs, which included all of our executive compensation peers:

2024 Proxy Statement   45

[MISSING IMAGE: hr_greenltsm-4c.jpg]
[MISSING IMAGE: bc_line-4c.jpg]
ACADIA Pharmaceuticals, Inc. (Nasdaq: ACAD)Krystal Biotech, Inc. (Nasdaq: KRYS)
ADMA Biologics, Inc. (Nasdaq: ADMA)Ligand Pharmaceuticals Incorporated (Nasdaq: LGND)
Agios Pharmaceuticals, Inc. (Nasdaq: AGIO)MacroGenics, Inc. (Nasdaq: MGNX)
Alkermes plc (Nasdaq: ALKS)MannKind Corporation (Nasdaq: MNKD)
Amicus Therapeutics, Inc. (Nasdaq: FOLD)Mirati Therapeutics, Inc. (Nasdaq: MRTX)
Apellis Pharmaceuticals, Inc. (Nasdaq: APLS)Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM)
Ardelyx, Inc. (Nasdaq: ARDX)Neurocrine Biosciences, Inc. (Nasdaq: NBIX)
BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX)Organogenesis Holdings Inc.(Nasdaq: ORGO)
Blueprint Medicines Corporation (Nasdaq: BPMC)Pacira BioSciences, Inc. (Nasdaq: PCRX)
Catalyst Pharmaceuticals, Inc. (Nasdaq: CPRX)PTC Therapeutics, Inc. (Nasdaq: PTCT)
Coherus BioSciences, Inc. (Nasdaq: CHRS)Rhythm Pharmaceuticals, Inc. (Nasdaq: RYTM)
Corcept Therapeutics Incorporated (Nasdaq: CORT)Sage Therapeutics, Inc. (Nasdaq: SAGE)
Deciphera Pharmaceuticals, Inc. (Nasdaq: DCPH)Sarepta Therapeutics, Inc. (Nasdaq: SRPT)
Dynavax Technologies Corporation (Nasdaq: DVAX)Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN)
Exelixis, Inc. (Nasdaq: EXEL)TG Therapeutics, Inc. (Nasdaq: TGTX)
Halozyme Therapeutics, Inc. (Nasdaq: HALO)Travere Therapeutics, Inc. (Nasdaq: TVTX)
ImmunoGen, Inc. (Nasdaq: IMGN)Ultragenyx Pharmaceutical Inc. (Nasdaq: RARE)
Incyte Corporation (Nasdaq: INCY)United Therapeutics Corporation (Nasdaq: UTHR)
Insmed Incorporated (Nasdaq: INSM)Vanda Pharmaceuticals Inc. (Nasdaq: VNDA)
Ionis Pharmaceuticals, Inc. (Nasdaq: IONS)Vericel Corporation (Nasdaq: VCEL)
In connection with his appointment as interimFebruary 2024, our named executive officers, other than our chief executive officer, were granted RSUs and PSUs, in each case under our Amended 2019 Plan. In March 2024, our chief executive officer was granted RSUs and PSUs, in each case under our Amended 2019 Plan. RSUs granted in 2024, other than for our chief executive officer, vest as to 25% of the underlying shares on each approximate anniversary of the grant date of the award, subject to continued employment on each vesting date, which is the vesting schedule typically used for RSU awards granted to employees. RSUs granted in 2024 for Mr. McCourt vest as to 33.3% of the underlying shares on each approximate anniversary of the grant date of the award, subject to his continued employment on each vesting date. As described above, the 2024 PSU awards are subject to aTSR and rTSR performance goals, and are measured over a three-year performance period ending February 28, 2027.

46   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
The RSUs and PSUs granted to our named executive officers in either February or March of 2024, as applicable, were as follows:
[MISSING IMAGE: bc_line-4c.jpg]
Named Executive Officer2024 Annual PSU Grant
(# of Shares of Class A common stock
Subject to PSUs) (at target)
2024 Annual RSU Grant
(# of Shares of Class A common stock
Subject to RSUs)
Thomas McCourt264,876264,876
Sravan Emany65,31265,312
Andrew Davis65,31265,312
John Minardo54,42654,427
Michael Shetzline, M.D., Ph.D.54,42654,427
Basis for Our Compensation Policies and Decisions
Our Values and Goals
The objectives of our compensation policies are to provide compensation and incentives that align employee actions and motivations with the interests of our stockholders; attract, retain, motivate and reward outstanding talent across Ironwood through well-communicated programs that are aligned with our vision and mission; and support a positive company culture and values.
We are guided by the following principles with respect to our compensation determinations:

design compensation and incentive programs that align employee actions and motivations with the interests of our stockholders, support our business objectives and hold employees accountable for the achievement of key goals and milestones;

foster and support our performance-driven culture by setting clear, aggressive, high-value goals, rewarding outstanding performers to the extent these goals are achieved, and making sure our best performers know clearly that we value their contributions;

as with all spending, serve as careful stewards of our stockholders’ assets when making compensation decisions;

maximize our employees’ sense of ownership so that they have a long-term owner’s perspective, can see the impact of their efforts on our success, and can share in the benefits of that success through the opportunity to become stockholders of Ironwood through equity-based awards;

recognize that compensation is one of a number of tools to stimulate and reward productivity, great drug development, and successful commercialization, together with recognizing individual growth potential, providing a great workplace culture, and sharing in our success;

foster a strong team culture, focused on our principles of great drug development and commercialization, which is reinforced through our compensation and incentive programs;

design compensation and incentive programs that are fair, equitable and competitive; and

design compensation and incentive programs that are simple and understandable.

2024 Proxy Statement   47

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Executive Compensation Governance
Highlighted procedures and tools that we use to ensure the effective upon Mr. Mallon's resignation, governance of our compensation plans and decisions include:

our compensation and HR committee recommendedhas the authority to hire independent counsel, compensation consultants and other advisors;

our board determinedcompensation and HR committee conducts a regular review and assessment of risk as it relates to increase Mr. McCourt's annual base salaryour compensation policies and practices;

as part of our insider trading prevention policy, our executive officers and directors are prohibited from $573,200engaging in any hedging or monetization transactions with respect to $775,000our securities, including through the use of financial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds;

other than our broad-based benefits, including health, transportation, remote work and well-being stipends and a 401(k) plan that we make available to increase Mr. McCourt's annual cash incentive bonus target from 60% (of $573,200) to 75% (of $775,000). The increase in annual base salaryour U.S.-based employees, we offer limited perquisites, as described herein;

our executive severance agreements (i) do not provide for tax gross-ups and annual cash incentive bonus target was intended to align Mr. McCourt's compensation(ii) contain double-trigger requirements for his service as our interim chief executive officer with Mr. Mallon's compensation as our chief executive officer. Mr. McCourt's increased salaryequity acceleration and annual cash incentive bonus target will remain in place for a minimum of six months and for so long as Mr. McCourt is serving as our interim chief executive officer. Mr. McCourt's severance arrangements andother benefits in the event of a change of control did not changecontrol;

eight of our nine directors are independent, including all members of our compensation and HR committee, and we have instituted stock ownership guidelines that require directors to accumulate and continuously hold a specified amount of our Class A common stock (see Director Stock Ownership Guidelines elsewhere in connectionthis proxy statement for additional information);

we have instituted executive stock ownership guidelines that require executive officers to accumulate and continuously hold a specified amount of our Class A common stock (see Executive Officer Stock Ownership Guidelines elsewhere in this proxy statement for additional information); and

we adopted a new clawback policy in accordance with his appointment as interim chiefthe requirements of the Dodd-Frank Act, final SEC rules and applicable Nasdaq listing standards effective October 2023. The clawback policy requires the clawback of erroneously awarded incentive-based compensation of former or current executive officer. In making its recommendationsofficers awarded during the three-year period preceding the date on which the company was required to prepare an accounting restatement due to the boardmaterial noncompliance of the company with any financial reporting requirement under the securities laws. There is no fault or misconduct required to trigger a clawback and we will not indemnify any former or current executive officers against the loss of any erroneously awarded compensation that is recouped pursuant to the terms of the clawback policy, or any claims relating to these compensation changes for Mr. McCourt's service as our interim chief executive officer,enforcement of our rights under the clawback policy.
Compensation Determination Process
Our corporate governance guidelines and the charter of the compensation and HR committee considered competitive market practiceprovide that (i) our board should assess the company’s corporate performance and a desire to recognize Mr. McCourt for his willingness to assume the interim chief executive officer role and the increased responsibility associated with such role.

2021 Retention Awards

In light of Mr. Mallon's resignation as the company's chief executive officer in March 2021, in an effort to promote business continuity,(ii) our compensation and HR committee approved a cash retention bonusshould recommend, and an RSU retention award tothe independent directors of our other four namedboard should approve, the compensation determination for our chief executive officers who remained employed withofficer. In determining the companycompensation of our chief executive officer, the independent directors of our board deliberate and vote on the datechief executive officer’s compensation outside of the grant. Cash retention bonuses were valued at 50%presence of the namedchief executive officer's 2021 base salary,officer, and RSU awards were valued at 33%the chief executive officer and any other non-independent directors abstain from such determination.

In January 2024, our board met and, following the recusal of each executive officer's 2021 annual equity target. In establishingnon-independent directors, approved our corporate goal achievement for 2023. Following the size of these grants, Aon presented market data and assistedboard’s corporate goal assessment, our compensation and HR committee with approximatingevaluated the value that another organization could potentially offer as a sign-on grant to recruitperformance of our executive talent relativeofficers (other than Mr. McCourt), including performance against goals and objectives relevant to such executive officers’ compensation, and then approved salary increases, 2023 cash incentive bonuses and 2024 cash incentive bonus targets and equity awards for 2024 for these executives. The compensation and HR committee similarly evaluated Mr. McCourt’s performance and made a recommendation to the

48   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
independent directors of our board relating to Mr. McCourt’s bonus for 2023 performance (which was determined based on company performance) and his annual equity award, base salary and target bonus percentage for 2024. In making these compensation-related decisions or recommendations for 2023 performance, our compensation and HR committee considered the current, unvested Ironwoodcompetitive assessment prepared by Alpine, as described in more detail below, as well as the other factors described in this Compensation Discussion and Analysis.
At its meeting in March 2024, the independent directors of our board approved Mr. McCourt’s 2023 bonus, and 2024 salary increase, equity heldawards and target bonus percentage; Mr. McCourt was not present for the independent directors’ deliberation and determination on these compensation items.
The compensation and HR committee also reviews our bonus pool, which is calibrated based on corporate performance, and approves our equity pools, which are calibrated for competitive market practice, and assigns a portion of each of these pools to all of our employees other than our executive officers. Allocation decisions with respect to these portions are made by members of senior management designated by our namedcompensation and HR committee.
Our compensation and HR committee also evaluates our compensation policies annually, taking into consideration our results of operations, our long and short-term goals, individual goals, market data, the competitive market for our executive officers.

Cash retention bonuses were awarded inofficers and general economic factors. Additionally, our compensation and HR committee or board (in the following amounts: Mr. McCourt (whose cash and RSU retention grants were made in his capacity as president, and not as interimcase of the determinations relating to chief executive officer) received a cashofficer compensation) may recommend or decide, as appropriate, to modify the mix or amount of base salary, bonus, and long-term incentives to best fit an executive officer’s specific circumstances or, if warranted by competitive market conditions, to grant retention bonus of $286,600, Ms. Consylman received a cash retention bonus of $254,700, Mr. Rickard received a cash retention bonus of $242,100 and Dr. Shetzline received a cash retention bonus of $242,000. The cash retention bonuses are payable in two equal payments with 50% of the cash retention bonus paid in September 2021 and 50% of the cash retention bonus paid in June 2022, subject to the officer remaining an employee of the company in good standing on each payment date. Each executive also will receive both payments in the event of an involuntary termination of employment prior to June 1, 2022.

RSU retention awards were made in the following amounts: Mr. McCourt received 96,638 RSUs, Ms. Consylman received 56,372 RSUs, Mr. Rickard received 56,372 RSUs and Dr. Shetzline received 38,665 RSUs. The RSU retention awards are subject to provisions relating to the acceleration of time-basedor additional equity awards under eachto attract, retain and motivate skilled personnel. We believe that this discretion and flexibility allows our compensation and HR committee and board (in the case of determinations of our chief executive officers' severance agreement, as described elsewhere in this proxy statement under the captions Executive Severance Agreements and Benefits in the Event of a Change of Control and Potential Payments Upon Termination or Change of Control.

44    Ironwood


Table of Contents

GRAPHIC officer’s compensation) to better achieve our compensation objectives.

Executive Officer Stock Ownership Guidelines

Following a competitive assessment of market data related to executive officer stock ownership requirements provided by Aon and guidance published by Investor Advisory Service, in October 2020, our compensation and HR committee recommended, and, in December 2020, our board approved, Executive Officer Stock Ownership Guidelines. In February 2022, our compensation and HR committee amended and restated our Executive Officer Stock Ownership Guidelines to exclude the value of vested “in the money” stock options towards satisfying our executive officer stock ownership requirements. We believe our Executive Officer Stock Ownership Guidelines further align the interests of our executive officers with those of our stockholders and also incentivize executive officers to focus on maximizing long-term value.

Our Executive Officer Stock Ownership Guidelines, which apply to each of our executive officers as defined in the Exchange Act,amended, provide that our chief executive officer is required to hold shares of the Company'scompany’s Class A common stock with a value equal to at least four (4) times his or her annual base salary and that othereach executive officers areofficer is required to hold shares of the Company'scompany’s Class A common stock with a value equal to one (1) times his or her annual base salary. Executive officers are required to achieve the applicable level of ownership by the later of December 2025 (five years from the date of adoption of the Executive Officer Stock Ownership Guidelines)Guidelines in December 2020) or the fifth anniversary of the date a person was initially designated as an executive officer of the Company.company. Shares that count towards satisfaction of the Executive Officer Stock Ownership Guidelines include among other forms of ownership, shares held outright by the executive officer or a member of his or her immediate family, shares held in trust for the benefit of the executive officer or a member of his or her immediate family, shares held in the company’s employee stock purchase plan or deferred compensation retirement plans and unvested RSUs net of applicable taxes. Vested “in the in-the-money value of vestedmoney” stock options and certain other vested and unvested equity awards (other than unearned performance-based awards), netawards do not count towards satisfaction of applicable taxes and the exercise price (if applicable).

these ownership requirements.

Compliance with the stock ownership requirements will be measured on the date of the annual meeting of stockholders of the company each year based on the annualized salary then in effect for each officer. Failure to comply with the Executive Officer Stock Ownership Guidelines will (among other things, as may be determined by the compensation and HR committee) require executive officers to retain at least 100% of the shares, net of applicable tax withholding and the payment of any exercise or purchase price (if applicable), received upon the vesting or settlement of equity

2024 Proxy Statement   49

[MISSING IMAGE: hr_greenltsm-4c.jpg]
awards or the exercise of stock options.

Basis for Our Compensation Policies and Decisions

Our Values and Goals

The objective As of our compensation policies is to provide compensation and incentives that align employee actions and motivations with the interestsMarch 31, 2024, each of our stockholders; attract, retain, motivate and reward outstanding talent across Ironwood through well-communicated programs that are aligned with our vision and mission; and support a positive company culture.

We are guided by the following principles with respect to our compensation determinations:

    design compensation and incentive programs that align employee actions and motivations with the interests of our stockholders, support our business objectives and hold employees accountable for the achievement of key goals and milestones;

    foster and support our performance-driven culture by setting clear, aggressive, high value goals, rewarding outstanding performers to the extent these goals are achieved, and making sure our best performers know clearly that we value their contributions;

    as with all spending, serve as careful stewards of our stockholders' assets when making compensation decisions;

2021  Proxy Statement    45


Table of Contents

GRAPHIC
    maximize our employees' sense of ownership so that they have a long-term owner's perspective, can see the impact of their efforts on our success, and can share in the benefits of that success through the opportunity to become stockholders of Ironwood through equity-based awards;

    recognize that compensation is one of a number of tools to stimulate and reward productivity, great drug development, and successful commercialization, together with recognizing individual growth potential, providing a great workplace culture, and sharing in our success;

    foster a strong team culture, focused on our principles of great drug development and commercialization, which is reinforced through our compensation and incentive programs;

    design compensation and incentive programs that are fair, equitable and competitive; and

    design compensation and incentive programs that are simple and understandable.

Executive Compensation Governance

Highlighted procedures and tools that we use to ensure effective governance of compensation plans and decisions include:

    our compensation and HR committee has the authority to hire independent counsel, compensation consultants and other advisors;

    our compensation and HR committee conducts a regular review and assessment of risk as it relates to our compensation policies and practices;

    as part of our insider trading prevention policy, our executive officers and directors are prohibited from engagingwas in any hedging or monetization transactionscompliance with respect to our Class A common stock, including through the use of financial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds;

    we have no perquisites other than broad-based benefits, including health and welfare benefits, transportation and fitness stipends, a 401(k) plan and a relocation program that we make available to all of our employees; under our relocation program, participants are required to pay back the full amount of all relocation benefits in connection with their departure from Ironwood in certain circumstances;

    our executive severance agreements (i) do not provide for tax gross-ups and (ii) contain double-trigger requirements for equity acceleration and other benefits in the event of a change of control;

    nine of our ten directors are independent, including all members of our compensation and HR committee, and we have instituted stock ownership guidelines that will require directors to accumulate and continuously hold a specified amount of our Class A common stock (see Director Stock Ownership Guidelines elsewhere in this proxy statement for additional information);

    we have instituted executive stock ownership guidelines that will require executive officers to accumulate and continuously hold a specified amount of our Class A common stock (see Executive Officer Stock Ownership Guidelines elsewhere in this proxy statement for additional information); and

    we have a clawback policy that provides our board of directors, in the event of a financial restatement due to material noncompliance with financial reporting requirements and where an executive engaged in intentional misconduct that caused or partially caused the need for the restatement, with the discretionary right to recover from our current and former executive officers that portion of the bonus or other incentive compensation that was received by the covered executives or effect the cancellation of unvested and vested equity awards previously granted to the covered executives based on our financial performance results and that would not have been awarded based on the restated results. The board of

46    Ironwood


Table of Contents

GRAPHIC Guidelines.

      directors' recovery rights under this policy will be without prejudice to other remedies the company may have for the recovery or adjustment of incentive compensation. Additionally, if we are required to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws as a result of misconduct, our chief executive officer and chief financial officer may be legally required to reimburse us for any bonus or other incentive-based or equity-based compensation they receive in accordance with the provisions of section 304 of the Sarbanes-Oxley Act of 2002.

Compensation Determination Process

Historically, our compensation and HR committee has determined our corporate performance for the prior year and also approved the compensation of all executive officers, including our chief executive officer. In December 2020, the board approved updates to our corporate governance guidelines and the charter of the compensation and HR committee to provide that, beginning in 2021, (i) our board would assess the Company's corporate performance and (ii) our compensation and HR committee would recommend, and our board would approve, the compensation determination for our chief executive officer. In determining the compensation of our chief executive officer, the board deliberates and votes on the chief executive officer's compensation outside of the presence of the chief executive officer, and the chief executive officer and any other non-independent directors abstain from such determination. Our compensation and HR committee and board similarly followed this process in 2021 in determining compensation for Mr. McCourt that specifically related to his service as our interim chief executive officer.

In January 2021, our board met and, following the recusal of non-independent directors, our board approved our corporate goal achievement for 2020. Following the board's corporate goal assessment, our compensation and HR committee evaluated the performance of our executive officers (other than Mr. Mallon), including performance against goals and objectives relevant to such executive officers' compensation, and then approved salary increases, cash bonuses and equity awards for our executive officers (other than Mr. Mallon). The compensation and HR committee similarly evaluated Mr. Mallon's performance and made a recommendation to the board relating to Mr. Mallon's bonus for 2020 performance; the compensation and HR committee did not make a recommendation as to go forward compensation for Mr. Mallon as Mr. Mallon had indicated his intent to resign at the time compensation decisions were made. In making these compensation-related decisions or recommendations for 2020 performance, our compensation and HR committee considered the competitive assessment prepared by Aon, as described in more detail below, as well as the other factors described in this Compensation Discussion and Analysis.

At its meeting in March 2021, following the recusal of non-independent directors, the board voted on Mr. Mallon's 2020 bonus; Mr. Mallon was not present for the board's deliberation on his 2020 bonus.

The compensation and HR committee also approves our bonus pool, which is calibrated based on corporate performance, and our equity pools, which are calibrated for competitive market practice, and assigns a portion of each of these pools to all of our employees other than our executive officers. Prior to Mr. Mallon's resignation, the compensation and HR committee delegated allocation of these portions to an RSU committee, which was comprised only of Mr. Mallon; following Mr. Mallon's resignation, allocation decisions will be made by members of senior management designated by our compensation and HR committee.

Our compensation and HR committee also evaluates our compensation policies annually, taking into consideration our results of operations, our long and short-term goals, individual goals, market data, the competitive market for our executive officers and general economic factors. Additionally, our compensation and HR committee or board (in the case of the determinations relating to chief executive officer compensation) may recommend or decide, as appropriate, to modify the mix or amount of base salary, bonus, and long-term incentives to best fit an executive

2021  Proxy Statement    47


Table of Contents

GRAPHIC

officer's specific circumstances or, if warranted by competitive market conditions, to attract, retain and motivate skilled personnel. For example, our compensation and HR committee may recommend or decide, and our board may decide with respect to our chief executive officer, to grant additional equity awards to an executive officer if that officer receives a base salary or cash bonus award significantly below that of his or her counterparts in our peer group, despite successful attainment of our corporate goals or his or her individual goals. We believe that this discretion and flexibility allows our compensation and HR committee and board (in the case of determinations of our chief executive officer's compensation) to better achieve our compensation objectives.

Role of the Compensation and HR Committee

As set forth in its written charter, our compensation and HR committee has the responsibility for evaluating the performance of our executive officers, taking into account the determination of our board with respect to our corporate performance; reviewing and approving the compensation of our executive officers (other than our chief executive officer); reviewing and recommending to the board our chief executive officer'sofficer’s compensation; recommending to the board the adoption of new compensation plans; administering our existing plans; reviewing and recommending director and committee compensation to the board; reviewing and overseeing our Executive Officer Stock Ownership Guidelines; overseeing succession planning for our senior management; reviewing and recommending to the board for approval of any “clawback” or recoupment policy; reviewing risks associated with our compensation policies and practices.practices; and overseeing our strategies and policies related to human capital management, including with respect to matters such as diversity and inclusion, workplace environment and culture, and talent development and retention. In addition, our compensation and HR committee is responsible for ensuring that our compensation policies are aligned with our compensation philosophy and guiding principles.

In 2020,2023, our compensation and HR committee made all of the compensation determinations with respect to each of our 2020 named executive officers, including ratifying and approving compensation paid or awarded toother than Mr. Rickard and Dr. Shetzline prior to their designation as executive officers of the company in April 2020. As described above, beginning in 2021, our compensation and HR committee recommended, and our board approved, compensation determinations for Mr. Mallon, including compensation determinations made in recognition of performance in 2020, as well as compensation determinations for Mr. McCourt in 2021 in respect of his service as our interim chief executive officer.

McCourt.

In making its determinations with respect to each of our named executive officers (other than Mr. Mallon) relating to compensation for performance in 2020,2023, our compensation and HR committee took into account the feedback and recommendations from Mr. Mallon, as well asMcCourt, including the feedback Mr. McCourt received from the named executive officer'sofficer’s direct reports and other members of our management team.

The components of each of our named executive officer's initial compensation package was based on numerous factors, including:

    the individual's particular background and circumstances, including prior relevant work experience and compensation paid prior to joining us;

    the individual's role with us and the compensation paid to similar persons in the companies represented in the compensation data that our compensation and HR committee reviewed;

    the demand for people with the individual's specific expertise and experience at the time of hire;

    performance goals and other expectations for the position;

    comparison to other executive officers within Ironwood having similar levels of expertise and experience; and

    uniqueness of industry skills.

48    Ironwood


Table of Contents

GRAPHIC

Role of the Compensation Consultant: Benchmarking and Peer Group Analysis

Our compensation and HR committee has the authority to select and retain independent advisors and consultants to assist it with carrying out its responsibilities, and we are required to pay any related expenses approved by the committee. In 2020,2023, our compensation and HR committee exercised such authority and engaged Aon as its compensation consultant.consultant from January until August and replaced Aon with Alpine from September through December. Alpine was selected based upon its reputation and experience as a compensation consultant and in its work with companies similar to Ironwood. Each of Aon and Alpine, at each compensation consultants respective time, reported directly to our compensation and HR committee throughout the period of itseach compensation consultants engagement.
Other than the purchase of certain benefits surveys, director and employee compensation benchmarking data from Aon and Alpine in 20202023 and certain other accounting and consulting services requested by the company related to equity plan matters, including forfeiture rate analysis, PSU award design, and 20202023 rTSR PSU valuation,and Pay versus Performance valuations, Aon and Alpine did not provide us with services in 20202023 other than those requested by our compensation and HR committee and the review of this Compensation Discussion and Analysis for conformance with best practices. Based on the scope of our compensation and HR committee'scommittee’s engagements with both Aon and Alpine, it was determined that neither Aon did not havenor Alpine had a conflict of interest in its roletheir respective roles as compensation consultant under applicable rules.

rules for the period of their engagement.

In order to assist our compensation and HR committee in setting 2020 and 20212023 compensation, respectively, Aon conducted competitive assessments of 2019 and 20202022 target compensation for our named executive officers, with a focus on the following components of our named executive officer compensation:


base salary;


target total cash compensation (which is base salary plus the target bonus);


long-term equity incentives (which are valued based on grant date fair value); and


target total direct compensation (which is target total cash compensation plus the grant date value of the most recent long-term incentive grant).


50   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
In conducting this assessment, Aon analyzed the components of our named executive officer compensation listed above, in each case measured against the 25th, 50th25th, 50th and 75th75th percentiles of our executive compensation peer group. Our peer group is reviewed at least annually by our compensation and HR committee. In setting our peer group, our compensation and HR committee applies a qualitative lens to help focus the potential group on the companies with which we are competing for talent. Our compensation and HR committee first identifies a potential pool of peer companies from a number of sources, including the companies listing Ironwood in their peer groups and the other companies listed in such peer companies'companies’ peer groups, as well as companies included in third party peer group assessments. Our compensation and HR committee then considers certain size filters including market capitalization, revenue, and number of employees, as well as certain business model filters including commercial focus, and growth. The peer group that Aon proposed and that the compensation and HR committee used as a reference point in connection with 20202023 compensation decisions is composed of the following 17 companies, which at the time they were designated as our peer group had a median 30-day average market capitalization of approximately

2021  Proxy Statement    49


Table of Contents

GRAPHIC

$2.7 $2.1 billion, median revenue of approximately $249$380 million, a median of 482495 employees, and a commercial drug or drug candidate in later stage development:

[MISSING IMAGE: bc_line-4c.jpg]
ACADIA Pharmaceuticals, Inc. (Nasdaq: ACAD)Ligand Pharmaceuticals Incorporated (Nasdaq: LGND)
Alkermes plc (Nasdaq: ALKS)Organogenesis Holdings Inc. (Nasdaq: ORGO)
Amicus Therapeutics, Inc. (Nasdaq: FOLD)Pacira BioSciences, Inc. (Nasdaq: PCRX)
Dynavax Technologies Corporation (Nasdaq: DVAX)PTC Therapeutics, Inc. (Nasdaq: PTCT)
Blueprint Medicines Corporation (Nasdaq: BPMC)Radius Health, Inc. (Nasdaq: RDUS)
Coherus BioSciences, Inc. (Nasdaq: CHRS)Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN)
Corcept Therapeutics Incorporated (Nasdaq: CORT)Vanda Pharmaceuticals Inc. (Nasdaq: VNDA)
Halozyme Therapeutics, Inc. (Nasdaq: HALO)Ultragenyx Pharmaceutical Inc. (Nasdaq: RARE)
Agios Pharmaceuticals, Inc.Horizon Therapeutics plc
Akcea Therapeutics, Inc.Intercept Pharmaceuticals, Inc. (Nasdaq: ICPT)
Alkermes plcPacira BioSciences, Inc.
Amicus Therapeutics, Inc.PTC Therapeutics, Inc.
bluebird bio, Inc.Radius Health, Inc.
Blueprint Medicines CorporationSupernus Pharmaceuticals, Inc.
Coherus BioSciences, Inc.United Therapeutics Corporation
Corcept Therapeutics Incorporated

In assisting our compensation and HR committee in setting 20202023 compensation, Aon also presented proxy peer data andas well as results from the Radford Global Life Sciences Survey, or Radford Survey, which was comprised of companies that represent a broader market perspective and similar employee population to us, and a Market Composite, which combined the peer group data and data from the Radford Global Life Sciences Survey data by weighting each source equally. Although this competitive assessment was not used to mandate any specific compensation decisions, our compensation and HR committee considered the results of this assessment when making base salary, cash bonus and long-term equity incentive award determinations with respect to our named executive officers in early 2020.

2023.

In October 2020,2023, our compensation and HR committee re-approved theapproved a new peer group, listed above, which peer group the compensation and HR committee continued to useAlpine used as a reference point in makingadvising our compensation and HR committee regarding compensation decisions throughmade beginning in the datefourth quarter of this proxy statement.

2023. Alpine recommended that five companies from our existing peer group be removed because they either no longer met the revenue screening criterium (Coherus BioSciences, Inc., Organogenesis Holdings Inc. and Vanda Pharmaceuticals, Inc.), or had been, or were in the process of being acquired (Intercept Pharmaceuticals, Inc. and Radius Health Inc.) and identified five potential companies (Ardelyx, Inc., BioCryst Pharmaceuticals, Inc., Insmed, Inc., Mirum Pharmaceuticals, Inc. and Travere Therapeutics, Inc.), to replace the five companies that were recommended to be removed from the prior peer group. This updated peer group is comprised of the following 17 companies, which at the time of approval by our compensation and HR committee had a median 30-day average market capitalization of approximately $1.5 billion, median revenue of approximately $427 million, a median of 250 employees and a commercial drug or drug candidate in later stage development:


2024 Proxy Statement   51

[MISSING IMAGE: hr_greenltsm-4c.jpg]
[MISSING IMAGE: bc_line-4c.jpg]
ACADIA Pharmaceuticals, Inc. (Nasdaq: ACAD)Insmed, Inc. (Nasdaq: INSM)
Alkermes plc (Nasdaq: ALKS)Ligand Pharmaceuticals Incorporated (Nasdaq: LGND)
Amicus Therapeutics, Inc. (Nasdaq: FOLD)Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM)
Ardelyx, Inc. (Nasdaq: ARDX)Pacira BioSciences, Inc. (Nasdaq: PCRX)
BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX)PTC Therapeutics, Inc. (Nasdaq: PTCT)
Blueprint Medicines Corporation (Nasdaq: BPMC)Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN)
Corcept Therapeutics Incorporated (Nasdaq: CORT)Travere Therapeutics, Inc. (Nasdaq: TVTX)
Dynavax Technologies Corporation (Nasdaq: DVAX)Ultragenyx Pharmaceutical Inc. (Nasdaq: RARE)
Halozyme Therapeutics, Inc. (Nasdaq: HALO)
Tax and Accounting Considerations

While our compensation and HR committee may consider the tax and accounting implications of its executive compensation decisions, neither element was a material consideration in the compensation awarded to our named executive officers in 2020.

2023.

Executive Compensation Risk Assessment

Our compensation and HR committee engaged AonAlpine to conduct a formal compensation risk assessment in December 2020.2023. The compensation and HR committee then reviewed our 20202023 compensation policies as generally applicable to our employees and determined that our policies did not encourage excessive and unnecessary risk-taking, and that the level of risk that they did encourage was not reasonably likely to have a material adverse effect on Ironwood.the company. Our compensation and HR committee considered the following, among other factors, in reviewing our compensation policies related to 20202023 compensation:


our use of different types of compensation vehicles provided a balance of long and short-term incentives with fixed and variable components;


we granted equity-based awards withconsisting of a mixed balance of time-based vesting and performance-based awards, which encouraged participants to look to long-term appreciation in equity values;


our annual bonus determinations for each employee were dependent on achievement of a diverse set of company-level goals, which we believe promoted long-term value; and


our system of internal control over financial reporting and code of business conduct and ethics, among other things, reduced the likelihood of manipulation of our financial performance to enhance payments under any of our incentive plans.

50


52   Ironwood



[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Compensation Committee Report
We have:
1.
reviewed and discussed with management the Compensation Discussion and Analysis found herein; and
based on the review and discussions referred to in paragraph (1) above, we recommended to the board of Contents

directors that the Compensation Discussion and Analysis be included in the company’s proxy statement on Schedule 14A for filing with the SEC.
By the Compensation and HR Committee,
Andrew Dreyfus, Chair
Mark Currie, Ph.D.
Jon Duane
Marla Kessler

GRAPHIC
2024 Proxy Statement   53

[MISSING IMAGE: hr_greenltsm-4c.jpg]

Compensation Tables

Summary Compensation Table

The following table sets forth information regarding the compensation paid or accrued to, or earned by, each of our named executive officers during the years ended December 31, 2020, 20192023, 2022 and 2018, as applicable.

2021, or such shorter period of the named executive officer’s service.
[MISSING IMAGE: bc_line-4c.jpg]
Name and Principal Position*YearSalary
($)(1)
Bonus
($)
Stock
Awards
($)(1)
Option
Awards
($)
Non-Equity
Incentive
Plan
Compensation
($)(2)
All Other
Compensation
($)(3)
Total
($)
Thomas McCourt
Chief Executive Officer
2023833,6685,974,255(4)750,78024,5677,583,270
2022805,404143,3006,473,069453,37518,1187,893,266
2021732,053143,3007,236,498680,06318,0908,810,004
Sravan Emany
Senior Vice President, Chief
Financial Officer
2023535,0001,843,347(5)361,33517,5502,757,232
2022500,000198,75013,612712,362
202128,846200,0002,300,100462,528,992
Andrew Davis
Senior Vice President, Chief
Business Officer
2023479,6151,843,347(6)322,56022,1852,667,708
2022
2021
John Minardo
Senior Vice President, Chief
Legal Officer and Secretary
2023511,9271,626,486(7)284,92917,5502,440,891
2022493,6351,734,155166,72515,5252,410,040
2021191,827250,0002,595,002105,0376,4273,148,293
Michael Shetzline
Senior Vice President, Chief
Medical Officer, and Head of
Research and Drug
Development
2023533,1671,734,924(8)309,73317,5502,595,374
2022512,482121,0002,080,982188,73515,5252,918,724
2021483,447121,0001,727,931285,40518,0902,635,873

Name and Principal Position*

  Year  Salary
($)(1)
  Bonus
($)
  Stock
Awards
($)(2)
  Option
Awards
($)(2)
  Non-Equity
Incentive Plan
Compensation
($)(3)
  All Other
Compensation
($)(4)
  Total
($)
 

Mark Mallon*

 2020 801,173  5,423,731  585,169 11,040 6,821,113 

Former Chief Executive

 2019 750,000 880,000 3,692,810 3,804,331 797,063 144,596 10,068,800 

Officer

 2018        

Gina Consylman

  2020  512,751    1,676,402    264,652  11,040  2,464,845 

Chief Financial Officer and

  2019  480,000  250,000  1,467,731  888,546  358,800  8,502  3,453,579 

Senior Vice President

  2018  415,000    782,385  501,764  207,500  8,040  1,914,688 

Thomas McCourt*

 2020 576,120  2,465,327  357,409 11,040 3,409,896 

President and Interim

 2019 511,250  1,760,143 2,370,159 454,272 8,502 5,104,327 

Chief Executive Officer

 2018 465,000  549,641 869,479 232,500 34,002 2,150,622 

Jason Rickard

  2020  473,314    1,479,191    258,338  11,040  2,221,883 

Chief Operating Officer and

  2019               

Senior Vice President

  2018               

Michael Shetzline, M.D., Ph.D.

 2020 464,681 100,000(5)1,121,001(6) 194,558 11,040 1,891,310 

Chief Medical Officer, Senior

 2019        

Vice President and Head of

 2018        

Drug Development Development

                 
*
*
Mr. Mallon resigned from the company effective on March 12, 2021. In connection therewith, Mr. McCourt became the company's interim chiefDavis was not a named executive officer in addition to his role as the company's president.

(1)
Salaries reported for 2020 reflect amounts paid in 2020 (as opposed to annual base salary rates). Fiscal year 2020 included one more pay date than fiscal years 20192021 and 2018.

(2)
For 2020, reflects2022.
(1)
Reflects the fair value of RSU and PSU awards on the date of grant calculated in accordance with Financial Accounting Standards Board issued Accounting Standards Codification Topic 718, Compensation—Stock Compensation, or ASC 718. For a discussion of the assumptions used in the valuation of awards made in 2020,2023, see Note 1413 to our consolidated financial statements for the year ended December 31, 20202023 included in our Annual Report on Form 10-K that we filed with the SEC on February 17, 2021.16, 2024. All values reported exclude the effects of potential forfeitures. Unless otherwise noted, amounts reported reflect the grant date fair value of RSUs and PSUs awarded in February 2020 in connection with annual equity awards. With respect to rTSR PSUs and aTSR PSUs granted to the named executive officers in 2020,2023, the aggregate grant date fair value was determined based on the probable outcometarget number of the performance conditions associated with such awards (target) at the date of grant. Assuming the maximum level of performance (200%) is achieved for the rTSR PSUs, the aggregate grant date fair value of the rTSR PSUs granted in 20202023 is as follows: $5,586,210 for Mr. Mallon, $1,726,622 for Ms. Consylman, $2,539,182$3,394,781 for Mr. McCourt, $1,523,504$1,047,442 for Mr. Rickard,Emany, $1,047,442 for Mr. Davis, $924,233 for Mr. Minardo and $1,145,974$985,837 for Dr. Shetzline.

(3)
Assuming the maximum level of performance (400%) is achieved for the aTSR PSUs, the aggregate grant date fair value of the aTSR PSUs granted in 2023 is as follows: $6,771,496 for Mr. McCourt, $2,089,327 for Mr. Emany, $2,089,327 for Mr. Davis, $1,834,510 for Mr. Minardo and $1,966,447 for Dr. Shetzline.
(2)
Consists of payments made under our annual cash bonus programACIP for performance in the relevant year. For a description of bonuses paid in 20212024 for performance in 2020,2023, see the disclosure included elsewhere in this proxy statement under the caption Annual Cash BonusIncentive Program for 2023 Performance.

(4)
(3)
For each executive officer, for 2020, $6,000 of such amount consists of matching contributions made under our 401(k) plan, and the remainder isas well as an amount attributable to a transportation stipendremote work and a fitness stipend.

(5)
Reflects paymentwell-being stipends. The 401(k) matching contribution for each named executive officer for 2023 was $14,850. Amounts for Messrs. McCourt and Davis also include $7,017 and $4,636, respectively, for the incremental cost of gifts, spousal travel and attendance at certain Ironwood-sponsored events and meetings where the second installmentexecutives’ attendance was requested by the company, as well as the value of Dr. Shetzline's sign-on bonus, which wasgifts received; these amounts are inclusive of tax gross-ups of $3,112 and $1,326 paid in early 2020 in accordance with the terms of his employment offer.

(6)
to Messrs. McCourt and Davis, respectively.
(4)
Includes the aggregate grant date fair value of (a) 28,135240,595 RSUs and 28,135240,594 PSUs awarded to Mr. McCourt in March 2023, in connection with annual equity awards.
(5)
Includes the aggregate grant date fair value of 74,236 RSUs and 74,235 PSUs awarded to Mr. Emany in March 2023, in connection with annual equity awards.
(6)
Includes the aggregate grant date fair value of 74,236 RSUs and 74,235 PSUs awarded to Mr. Davis in March 2023, in connection with annual equity awards.
(7)
Includes the aggregate grant date fair value of 65,502 RSUs and 65,502 PSUs awarded to Mr. Minardo in March 2023, in connection with annual equity awards.
(8)
Includes the aggregate grant date fair value of 69,869 RSUs and 69,869 PSUs awarded to Dr. Shetzline in February 2020March 2023, in connection with annual equity awards and (b) 20,740 RSUs and 20,740 PSUs awarded to Dr. Shetzline in April 2020 as a recognition award in connection with his designation as an executive officer of the company.awards.

2021  Proxy Statement    51


Table of Contents


GRAPHIC
54   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]

Grants of Plan-Based Awards

The following table sets forth information regarding non-equity and equity awards granted to each of our named executive officers during the year ended December 31, 2020.2023. All non-equity incentive plan awards were made pursuant to our cash bonus program described in more detail elsewhere in this proxy statement under the caption Annual Cash BonusIncentive Program for 2023 Performance.

We granted RSUs and PSUsannual long-term equity incentive compensation awards to our named executive officers in February 2020. We also granted Dr. Shetzline additionalthe form of RSUs and PSUs in April 2020 in connection with his designation as an executive officer of the company.

March 2023.

All RSUs and PSUs granted in 20202023 represented the right to receive shares of our Class A common stock upon the vesting of such awards. The vesting schedule of each such award included in the following table is described in the footnotes to the Outstanding Equity Awards at Fiscal Year-End table.

[MISSING IMAGE: bc_line-4c.jpg]
NameType of AwardGrant DateEstimated
Future Payouts
Under Non-Equity
Incentive Plan
Awards(1)
Target ($)
Estimated Future Payouts Under
Equity Incentive Plan Awards(2)(#)
All Other
Stock Awards:
Number of
Shares of
Stock or Units
(#)(3)
Grant Date
Fair Value of
Stock Awards
($)(4)
ThresholdTargetMaximum
Thomas McCourtRSUs3/8/2023240,595$2,583,990
rTSR PSUs3/8/202360,149120,297240,594$1,697,397
aTSR PSUs3/8/202360,149120,297481,188$1,692,874
ACIP$625,658
Sravan EmanyRSUs3/8/202374,236$797,295
rTSR PSUs3/8/202318,55937,11774,234$523,721
aTSR PSUs3/8/202318,55937,118148,472$522,332
ACIP$272,500
Andrew DavisRSUs3/8/202374,236$797,295
rTSR PSUs3/8/202318,55937,11774,234$523,721
aTSR PSUs3/8/202318,55937,118148,472$522,332
ACIP$240,000
John MinardoRSUs3/8/202365,502$703,491
rTSR PSUs3/8/202316,37632,75165,502$462,117
aTSR PSUs3/8/202316,37632,751131,004$460,878
ACIP$230,525
Michael ShetzlineRSUs3/8/202369,869$750,393
rTSR PSUs3/8/202317,46734,93469,868$492,919
aTSR PSUs3/8/202317,46834,935139,740$491,612
ACIP$240,103

     Compensation
and HR
Committee
Approval Date
(if different than
  Estimated
Future Payouts
Under Non-
Equity Incentive
Plan Awards(2)
  Estimated Future Payouts Under
Equity Incentive Plan Awards(3)(#)
  All Other
Stock Awards:
Number of
Shares of
Stock or
  Grant
Date Fair
Value of Stock
 

Name

  Grant Date  Grant Date)  Target ($)  Threshold  Target  Maximum  Units (#)(4)  Awards ($)(5)
 

Mark Mallon

 2/27/2020 2/20/2020     221,061 2,630,626 

 2/27/2020 2/20/2020  66,318 221,061 442,122  2,793,105 

   579,375      

Gina Consylman

  2/27/2020  2/20/2020          68,327  813,091 

  2/27/2020  2/20/2020    20,498  68,328  136,656    863,311 

      247,200           

Thomas McCourt

 2/27/2020 2/20/2020     100,482 1,195,736 

 2/27/2020 2/20/2020  30,145 100,482 200,964  1,269,591 

   333,840      

Jason Rickard

  2/27/2020  (1)         60,289  717,439 

  2/27/2020  (1)   18,087  60,289  120,578    761,752 

      228,375           

Michael Shetzline,

 2/27/2020 (1)    28,135 334,807 

    M.D., Ph.D.

 2/27/2020 (1) 8,441 28,135 56,270  355,487 

 4/24/2020(6)4/18/2020     20,740 213,207 

 4/24/2020(6)4/18/2020  6,222 20,740 41,480  217,500 

   179,220      
(1)
(1)
February 2020 equity awards for Mr. Rickard and Dr. Shetzline were granted on the date specified in the preceding column and were subsequently ratified by the compensation and HR committee following the appointment of each individual as an executive officer of the company.

(2)
Consists of the target cash bonus paymentamount for 20202023 performance under our cash bonus program.ACIP. As described in more detail elsewhere in this proxy statement under the caption Annual Cash BonusIncentive Program for 2023 Performance, in 2020, Mr. Mallon had an individual bonus target of 75% of his base salary,2023, Mr. McCourt had an individual bonus target percentage of 60%75% of his base salary, Ms. ConsylmanMessrs. Emany and Mr. Rickard eachDavis had an individual bonus target percentage of 50% of their respective base salaries, and Mr. Minardo and Dr. Shetzline had an individual bonus target percentage of 40%45% of histheir base salary. Seventy percent (70%)salaries. 70% of bonuses awarded for performance in 20202023 were tied solely to the achievement of our corporate goals for 2020,2023, and 30% of bonuses awarded were tied to the achievement of corporate and individual performance goals. In determining Mr. Mallon'sMcCourt’s cash bonus for 2020,2023, the board equated Mr. Mallon'sMcCourt’s individual performance with that of the company'scompany’s performance. Actual bonus payments for 20202023 performance are set forth in the Summary Compensation Table elsewhere in this proxy statement.

(3)
(2)
Awards listed in the "Estimated“Estimated Future Payouts Under Equity Incentive Plan Awards" Awards”column are rTSR and aTSR PSUs, and represent threshold, target and maximum potential future payouts underwith respect to the PSUsawards granted to each of our named executive officers in 2020.2023. The rTSR PSUs are eligible to vest based

52    Ironwood


Table of Contents

GRAPHIC

    on the achievement of certainan rTSR performance goalsgoal over a two or three-year performance period and aTSR PSUs are eligible to vest based on the achievement of share price targets during a three-year period as described elsewhere in this proxy statement under the caption 2020 Annual2023 Long-Term Equity Awards.

(4)
in the Compensation Discussion and Analysis above.
(3)
Stock awards listed in the "All“All Other Stock Awards: Number of Shares of Stock or Units (#)" column are RSUs.

(5)
(4)
Reflects the fair value of RSU and PSU awards on the date of grant calculated in accordance with ASC 718, excluding the effects of potential forfeitures, with the grant date fair value of PSUs determined based on the probable outcometarget number of the performance conditions (target) associated with such awards onat the grant date.date of grant. For a discussion of the assumptions used in the valuation of the RSU and PSU awards granted to our named executive officers in 2020,2023, see footnote 12 to the Summary Compensation Table elsewhere in this proxy statement.

(6)
Awarded to Dr. Shetzline in April 2020 as a recognition award in connection with his designation as an executive officer of the company.

2021


2024 Proxy Statement   53


Table of Contents

GRAPHIC 55

[MISSING IMAGE: hr_greenltsm-4c.jpg]

Outstanding Equity Awards at Fiscal Year-End

As described in our proxy statement relating to our 2020 annual meeting of stockholders, filed with the SEC on April 21, 2020,2021 Proxy Statement, portions of certain Ironwood equity awards were converted into Cyclerion equity awards in connection with our separation from Cyclerion Therapeutics, Inc., or Cyclerion, in April 2019, or the Separation.Separation, and are subject to substantially the same terms and conditions as were applicable to the Ironwood equity awards prior to the distribution. The following tables set forth information regarding outstanding Ironwood and Cyclerion equity awards held by each of our named executive officers on December 31, 2020,2023, the last day of our last fiscal year. Information presented has been adjusted, as necessary, to reflect the impact of the Separation.

The Cyclerion equity awards were granted to Mr. McCourt in connection with the Separation. None of our other named executive officers hold any Cyclerion equity awards.

Ironwood Equity Awards at Fiscal Year-End

[MISSING IMAGE: bc_line-4c.jpg]
Option AwardsStock Awards
NameNumber of
Securities
Underlying
Unexercised
Options
Exercisable
Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
Equity
Incentive
Plan
Awards:
Number of
Securities
Underlying
Unearned
Options (#)
Option
Exercise
Price ($)
Option
Expiration
Date
Number of
Shares of
Units of
Stock That
Have Not
Vested (#)
Market
Value of
Shares or
Units of
Stock That
Have Not
Vested ($)(1)
Equity
Incentive
Plan
Awards:
Number of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested (#)
Equity
Incentive
Plan
Awards:
Market or
Payout
Value of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested ($)(1)
Thomas McCourt80,50412.563/3/2024(2)
97,50013.913/16/2025(2)
179,0569.123/1/2026(2)
166,01814.932/27/2027(2)
142,40412.952/21/2028(2)
384,98211.491/29/2029(2)
45,70411.785/1/2029(2)
240,595(3)2,752,407
311,811(4)3,567,118
249,617(5)2,855,618
248,868(6)2,847,050
120,297(7)1,376,198
120,297(8)1,376,198
Sravan Emany116,736(4)1,335,460
85,000(5)972,400
37,117(7)424,618
37,118(8)424,630
Andrew Davis165,306(4)1,891,101
39,370(6)450,393
37,117(7)424,618
37,118(8)424,630
John Minardo156,353(4)1,788,678
79,981(5)914,983
67,873(6)776,467
32,751(7)374,671
32,751(8)374,671
Michael Shetzline92,69813.193/1/2029(9)
160,081(4)1,831,327
57,971(5)663,188
81,447(6)931,754
34,934(7)399,645
34,395(8)399,656
 
  
  
  
  
  
  
  
  
  
 

 Option Awards   Stock Awards   

Name

  Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
  Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
  Number of
Securities
Underlying
Unexercised
Unearned
Options (#)
  Option
Exercise
Price ($)
  Option
Expiration
Date
  Number
of Shares or
Units of Stock
That Have Not
Vested (#)
  Market Value
of Shares or
Units of Stock
That Have Not
Vested ($)(1)
  Equity Incentive
Plan Awards:
Number of
Unearned
Share, Units
or Other Rights
That Have Not
Vested (#)
  Equity Incentive
Plan Awards:
Market Value
of Unearned
Shares, Units
or Other Rights
That Have Not
Vested ($)(1)
 

Mark Mallon

 92,349 100,380  10.97 1/9/2029(2)    

 202,711 200,338  14.02 4/1/2029(2)    

      221,061(8)2,517,885   

      233,556(9)2,660,203   

        198,954(10)2,266,086 

Gina Consylman

  43,563      13.78  7/1/2024(2)            

  8,500      13.91  3/16/2025(3)            

  5,077      10.20  9/16/2025(3)            

  30,695      9.12  3/1/2026(3)            

  12,374  3,862    13.60  1/2/2028(3)            

  46,840  18,259    12.95  2/21/2028(3)            

  76,947  84,857    11.49  1/29/2029(3)            

            41,150(7) 468,699     

            68,327(8) 778,245     

            87,429(9) 995,816     

                61,494(10) 700,417 

Thomas McCourt

 95,971   13.11 2/1/2022(4)    

 110,962   11.65 2/1/2023(4)    

 80,504   12.56 3/3/2024(3)    

 97,500   13.91 3/16/2025(3)    

 179,056   9.12 3/1/2026(3)    

 162,331 3,687  14.93 2/27/2027(3)    

 102,463 39,941  12.95 2/21/2028(3)    

 183,082 201,900  11.49 1/29/2029(3)    

 18,091 27,613  11.78 5/1/2029(3)    

      115,220(7)1,312,356   

      100,482(8)1,144,490   

      36,800(9)419,152   

        90,435(10)1,030,055 

Jason Rickard

  18,041      11.65  2/1/2023(3)            

  7,754      11.76  6/10/2023(3)            

  10,309      9.66  12/16/2023(3)            

  40,834      12.02  11/3/2024(3)            

      11,236  13.11  2/1/2022(5)            

  2,000      13.11  2/1/2022(6)            

  15,550      13.91  3/16/2025(3)            

  6,046      9.79  9/1/2025(3)            

  17,956      9.12  3/1/2026(3)            

  39,535  43,598    11.49  1/29/2029(3)            

  5,426  8,285    11.78  5/1/2029(3)            

            41,153(7) 468,733     

            60,289(8) 686,692     

            60,616(9) 690,416     

                54,261(10) 618,033 

Michael Shetzline, M.D., Ph.D.

 44,418 48,280  13.19 3/1/2029(3)    

      43,869(7)499,668   

      48,875(8)556,686   

      11,586(9)131,965   

        43,989(10)501,035 
(1)
(1)
Market value reflectsis calculated by multiplying the number of RSUs or PSUs that have not vested by the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020, the last day of our fiscal year,29, 2023, which was $11.39.

54    Ironwood


Table of Contents

GRAPHIC $11.44.
(2)
(2)
The options vest as to 25% of the shares on the first anniversary of the vesting commencement date and 1/48th of the shares each month thereafter for the next 36 months, generally subject to the executive's continued employment with the company on the applicable vesting date.

(3)
The options vestvested as to 1/48th of the shares on each monthly anniversary of the vesting commencement date, generally subject to the executive'sexecutive’s continued employment with the company on the applicable vesting date.

(4)
The options vested as to 1.25% on each monthly anniversary of the vesting commencement date for the first 36 months, and as to 4.5833% of the award on each monthly anniversary thereafter, generally subject to the executive's continued employment with the company on the applicable vesting date.

(5)
The option vests upon global pharmaceutical product net sales (including partnered or licensed product revenue) exceeding $1 billion, generally subject to the executive's continued employment with the company on the applicable vesting date.

(6)
This option vested upon the acceptance by the U.S. FDA of an NDA for DUZALLO® (lesinurad).

(7)
RSUs vest in full on November 18, 2021, generally subject to continued employment with the company.

(8)

56   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
(3)
RSUs vest over three years as to 33.3% of the award on each approximate anniversary of the grant thereof, generally subject to continued employment with the company on the applicable vesting date.

(9)
(4)
RSUs vest over four years as to 25% of the award on each approximate anniversary of the grant thereof, generally subject to continued employment with the company on the applicable vesting date.

(10)
(5)
The 2021 rTSR PSUs vestvested over a two- to three-year period based on the achievement of the performance metrics discussed elsewhere in this proxy statement under the caption 20202021 rTSR PSUs Payout. The number of shares reported herein reflects target performance for the 2021 rTSR PSUs in accordance with SEC requirements. The payout for the 2021 rTSR PSUs, which was certified by the compensation and HR committee on January 17, 2024, was 100% of the target number of PSUs.
(6)
The 2022 rTSR PSUs vest over a three-year period based on the achievement of the performance metrics. The number of shares reported in this column assumes target performance for the 2022 rTSR PSUs in accordance with SEC requirements. Actual payouts for these PSUs could range from 0% to 200% of the target number of PSUs based on actual performance results. The 2022 rTSR PSUs also have a service-based vesting condition that generally will be satisfied by continued employment with the company through the last day of the applicable performance period. For a discussion of the treatment of rTSR PSUs following certain terminations of employment and/or a change of control of Ironwood, please see Named Executive Officer Severance Arrangements and Benefits in the Event of a Change of Control elsewhere in this proxy statement.
(7)
The 2023 rTSR PSUs vest over a three-year period based on the achievement of the performance metrics discussed elsewhere in this proxy statement under the caption 2023 Annual Equity Awards. The number of shares reported in this column assumes target performance for NDA Acceptance PSUs and the 20202023 rTSR PSUs and maximum performance for the Adjusted EBITDA PSUs, in each case in accordance with SEC requirements. Actual payouts for thethese PSUs could range from 0% to 200% of the target number of PSUs subject to an award based on actual performance results. The 2023 rTSR PSUs also have a service-based vesting condition that generally will be satisfied by continued employment with the company through the last day of the applicable performance period. For a discussion of the treatment of PSUs following certain terminations of employment and/or a change of control of Ironwood, please see Named Executive Officer Severance Arrangements and Benefits in the Event of a Change of Control elsewhere in this proxy statement.

2021  Proxy Statement    55


Table

The 2023 aTSR PSUs vest during a three-year period based on the achievement of Contents

GRAPHIC the performance metrics discussed elsewhere in this proxy statement under the caption 2023 Annual Equity Awards. The number of shares reported in this column assumes target performance for the 2023 aTSR PSUs in accordance with SEC requirements. Actual payouts for these PSUs could range from 0% to 400% of the target number of PSUs based on actual performance results. For a discussion of the treatment of aTSR PSUs following certain terminations of employment and/or a change of control of Ironwood, please see Named Executive Officer Severance Arrangements and Benefits in the Event of a Change of Control elsewhere in this proxy statement.
(9)
The options vested as to 25% of the shares on the first anniversary of the vesting commencement date and 1/48th of the shares each month thereafter for the next 36 months, generally subject to the executive’s continued employment with the company on the applicable vesting date.

Cyclerion Equity Awards at Fiscal Year-End

[MISSING IMAGE: bc_line-4c.jpg]
Number of Securities Underlying
Unexercised Options Exercisable(1)
Option
Exercise Price ($)(1)
Option
Expiration Date
Thomas McCourt379310.803/3/2024
487344.003/16/2025
710225.603/1/2026
442369.402/27/2027
205320.402/27/2028
107284.201/29/2029
(1)
The Cyclerion equity awards reflected innumber of securities underlying unexercised options exercisable and the following tableoption exercise price were granted to Ms. Consylman and Messrs. McCourt and Rickardadjusted in connection with the Separation. Each Ironwood equity award that was converted into a Cyclerion equity award is subject to substantially1-for-20 reverse stock split of Cyclerion’s common stock effected on May 16, 2023. Accordingly, the same termsnumber of securities and vesting conditions as were applicable tooption exercise prices shown in the Ironwood equity awards prior to the distribution. Neither Mr. Mallon nor Dr. Shetzline hold any Cyclerion equity awards.

table above reflect post reverse stock split holdings.

2024 Proxy Statement   57

[MISSING IMAGE: hr_greenltsm-4c.jpg]
 
  
  
  
 
Name
 Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable

 Option
Exercise
Price ($)

 Option
Expiration
Date

 

Gina Consylman

 1,117 17.05 7/1/2024 

 850 17.20 3/16/2025 

 437 12.61 9/16/2025 

 2,437 11.28 3/1/2026 

 500 16.82 1/2/2028 

 1,875 16.02 2/21/2028 

 906 14.21 1/29/2029 

Thomas McCourt

  5,464  12.24  2/1/2021 

  8,713  16.21  2/1/2022 

  10,221  14.40  2/1/2023 

  7,591  15.54  3/3/2024 

  9,750  17.20  3/16/2025 

  14,218  11.28  3/1/2026 

  8,859  18.47  2/27/2027 

  4,101  16.02  2/21/2028 

  2,156  14.21  1/29/2029 

Jason Rickard

 200 16.21 2/1/2022 

 857 14.40 2/1/2023 

 543 14.55 6/10/2023 

 750 11.95 12/16/2023 

 3,324 14.87 11/3/2024 

 1,555 17.20 3/16/2025 

 562 12.11 9/1/2025 

 1,425 11.28 9/1/2026 

 465 14.21 1/29/2029 

56    Ironwood


Table of Contents

GRAPHIC

Option Exercises and Stock Vested Table

The following table sets forth certain information regarding the exercise of options to purchase our Class A common stock and the vesting of RSUs that were held by our named executive officers during the year ended December 31, 2020.

2023.
[MISSING IMAGE: bc_line-4c.jpg]
Option AwardsStock Awards
NameNumber of Shares
Acquired on Exercise
(#)
Value Realized
on Exercise
($)(1)
Number of Shares
Acquired on Vesting
(#)
Value Realized
on Vesting
($)(2)
Thomas McCourt110,962(3)$46,816242,469$2,688,303
Sravan Emany21,250$200,600
Andrew Davis40,613$419,655
John Minardo36,941$389,749
Michael Shetzline89,069$991,313
 
  
  
  
  
 

 Option Awards   Stock Awards   

Name

  Number of Shares
Acquired on
Exercise
(#)
  Value Realized
on Exercise
($)(1)
  Number of Shares
Acquired on
Vesting
(#)
  Value Realized
on Vesting
($)(2)
 

Mark Mallon

   77,853 839,334 

Gina Consylman

      45,435  535,562 

Thomas McCourt

 119,988(3)$284,331 19,232 220,407 

Jason Rickard

      31,074  363,220 

Michael Shetzline, M.D., Ph.D.

   3,863 46,395 
(1)
(1)
Computed by determining the difference between the market price of our Class A common stock on the date of exercise and the exercise price of the exercised stock option, multiplied by the number of shares acquired upon exercise of the option.

(2)

Computed by multiplying the number of shares of Class A common stock underlying the vested RSUs by the market price of our Class A common stock on the vesting date.

(3)
Includes 99,988
Represents shares of our Class A common stock that Mr. McCourt acquired through an option exercise as such stock options were expiring of which 81,089 shares were surrendered to the company in a net share settlement and 18,899 shares were retained by Mr. McCourt, thereby increasing his ownership of our Class A common stock by such amount. Also includes 20,000 shares of our Class A common stock that Mr. McCourt acquired through option exercises as such stock options were expiring, and then sold on the open market.

Named Executive Officer Severance Arrangements and Benefits in the Event of a Change of Control

We have entered into severance arrangements with each of our named executive officers. Under the severance arrangements, our named executive officers are eligible to receive certain payments and benefits in the event of an involuntary termination without "cause"“cause” or a "constructive“constructive termination." Each of our executives is also eligible to receive enhanced payments and benefits in the event of a change of control plus an actual or constructive involuntary termination of employment (such double trigger event, a "change“change of control termination"termination”). For additional information, please see the definition of "change“change of control termination," below. The following descriptions reflect the payments and benefits that would have been payable to each of our named executive officers as of December 31, 20202023, under their respective severance arrangements.

The benefits for our named executive officers described elsewhere in this proxy statement under the captions Severance Benefits not in Connection with a Change of Control and Change of Control Severance Benefits are only payable if the named executive officer complies with all of Ironwood'sIronwood’s rules and policies, executes a separation agreement that includes a release of claims and complies with any post employmentpost-employment non-disclosure, non-competition and non-solicitation obligations. The executive severance agreements further provide that in connection with the sale of all or substantially all of the assets of Ironwood, Ironwood would cause the acquirer of such assets to assume the executives'executives’ severance arrangements.

2021  Proxy Statement    57


Table of Contents

GRAPHIC

Severance Benefits not in Connection with a Change of Control

In the event of a termination without cause or a constructive termination not qualifying as a change of control termination, each of our named executive officers would be entitled to receive the following: (i) for Messrs. Davis, Emany and Minardo, a lump-sum payment equal to 12 months of his or herbase salary for the year of termination; for Mr. McCourt, a lump-sum payment equal to 18 months of his base salary for the year of termination; and for Dr. Shetzline, a lump-sum payment equal to 12 months of his base salary for the year of termination plus an amount equal to a maximum of six months of his or her base salary for the period beginning as of the first anniversary of his or her termination date, provided he or she has not secured new, reasonably similar full-time employment (for our former chief executive officer, a lump-sum payment equal to 18 months of his base salary for the year of termination);employment; (ii) a lump-sum payment equal to his or her target cash bonus for the year of termination, pro-rated based on the percentage of the year worked prior to the triggering

58   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
event; (iii) a lump-sum payment equal to his or her actual bonus for the prior year if not yet paid as of the termination date; (iv) a lump-sum payment equal to his or her full target cash bonus for the year of termination (for our former chief executive officer,Mr. McCourt, multiplied by 1.5); (v) for Messrs. Davis, Emany and Minardo, up to 12 months of subsidized COBRA benefits; for Mr. McCourt, a period of up to 18 months of subsidized COBRA benefits; and for Dr. Shetzline, 12 months of subsidized COBRA benefits plus up to an additional six months of subsidized COBRA benefits for the period beginning as of the first anniversary of his or her termination date, provided he or she has not been eligible to participate in the group medical plan of another employer (for our former chief executive officer, 18 months of subsidized COBRA benefits);employer; and (vi) outplacement assistance benefits. The non-equity basednon-equity-based severance benefits described in items (i) through (vi) of this paragraph, collectively, are referred to as the "Non Equity“Non-Equity Severance Benefits."

In addition, eachthe executive severance agreement for Mr. McCourt and Dr. Shetzline provides that any outstanding equity awards subject solely to time-based vesting would vest as to (1) the portion of the equity award that would have vested if the named executive officer had remained employed for 18 months (for our former chief executive officer, 24 months) following the termination date and (2) an additional portion of the equity award that would have vested on the next regular vesting date after such 18-month period (for our former chief executive officer, such 24 month period) as if the equity award vested on a daily basis from the last regular award vesting date occurring prior to the end of the 18 month period (for our former chief executive officer, the 24 month period) through such next regular vesting date. Any equity awards that do not vest pursuant to the preceding sentence would remain outstanding and eligible to vest upon the occurrence of a change of control termination (as defined below) in the time periods described below for such a termination. Further, the exercisability of any outstanding vested stock options held by the named executive officer as of the termination date (including, other than for our former chief executive officer and Dr. Shetzline,Mr. McCourt, any vested options to purchase Cyclerion common stock that were granted in connection with the Separation in substitution for or replacement of vested options to purchase Ironwood Class A common stock) would be extended through the earlier of 24 months (for our former chief executive officer, 36 months) following the termination date (or, in the event that Ironwood publicly announced it was conducting negotiations leading to a change of control or entered into a definitive agreement that would have resulted in a change of control during such 24 month period, (for our former chief executive officer, such 36 month period), the later of (A) the expiration of the 24 month period (for our former chief executive officer, the 36 month period) or (B) the first to occur of the date that is three months following the change of control and 30 days following the date on which Ironwood announced that such definitive agreement had been terminated or that Ironwood'sIronwood’s efforts to consummate the change of control contemplated by the previously announced negotiations or by a previously executed definitive agreement had been abandoned) or the stock option'soption’s final expiration date. The equity-based severance benefits described in this paragraph are referred to as the "Equity“Equity Severance Benefits."

Moreover, with respect to PSUs, in the event of the named executive officer'sofficer’s involuntary termination without cause or constructive termination (collectively, a "qualifying termination"“qualifying termination”), the awards, to the extent then outstanding, will not terminate upon such termination of employment and instead will remain eligible to vest based on the attainment of the applicable performance goals. Specifically, the NDA Acceptance2023 aTSR PSUs and 2024 aTSR PSUs will generally remain outstanding and eligible to vest based upon the achievement of an NDAtheir respective 2023 aTSR and 2024 aTSR performance goalgoals until

58    Ironwood


Table of Contents

GRAPHIC

the earlier of (A) the end of the performance period or (B) the twelve (12)-month period following the date of the qualifying termination.termination, with the number of PSUs actually delivered subject to proration based on the number of days the named executive officer remained employed during the respective performance period. The Adjusted EBITDA2022 rTSR PSUs, 2023 rTSR PSUs and the 20202024 rTSR PSUsPRUs will generally remain outstanding and eligible to vest based upon the achievement of the cumulative adjusted organic EBITDA andtheir respective rTSR performance goals, respectively, until the end of the applicabletheir respective performance period, with the number of PSUs actually delivered subject to proration based on the number of days the named executive officer remained employed during the applicablerespective performance period.

Change of Control Severance Benefits

In the event of a change of control termination, each of our named executive officers would be entitled to receive the following benefits under his or her executive severance agreement: (1) a lump-sum payment in an amount equal to 18 months (for our chief executive officer,Mr. McCourt, 24 months) of his or her base salary as of the time of termination; (2) a lump-sum payment of his or her target cash bonus for the year of termination, pro-rated based on the percentage of the year worked prior to the triggering event; (3) a lump-sum payment equal to his or her actual bonus for the prior year if not yet paid as of the termination date; (4) a lump-sum payment equal to his or her full target cash bonus for the year of termination, multiplied by 1.5 (for our former chief executive officer,Mr. McCourt, multiplied by 2.0); (5) 18 months (for our former chief executive officer,Mr. McCourt, 24 months) of subsidized COBRA benefits; and (6) outplacement assistance benefits.


2024 Proxy Statement   59

[MISSING IMAGE: hr_greenltsm-4c.jpg]
In addition, in the event of a change of control termination, each executive severance agreement provides for acceleration of all outstanding equity awards subject solely to time-based vesting as of the later of (1) the termination date or (2) the change of control. Further, the exercisability of any outstanding vested stock options held by the named executive officer as of the termination date (including, other than for our former chief executive officer and Dr. Shetzline,Mr. McCourt, any vested options to purchase Cyclerion common stock granted in connection with the Separation in substitution for or replacement of vested options to purchase Ironwood Class A common stock) would be extended through the earlier of 24 months (for our former chief executive officer, 36 months) following the termination date (or, if later the date that was three months following the change of control) or the stock option'soption’s final expiration date.

Under each executive severance agreement, a "change“change of control termination"termination” consists of an involuntary termination without "cause"“cause” or a "constructive termination" (each“constructive termination” ​(each as defined in the agreement), in either event during the period commencing six months prior to the earlier of (1) the date that Ironwood first publicly announces it is conducting negotiations leading to a change of control, or (2) the date that Ironwood enters into a definitive agreement that would result in a change of control, and ending on the earlier of (A) the date on which Ironwood announces that the definitive agreement has been terminated or the negotiations have been abandoned or (B) the date that is 24 months after the change of control.control, provided that if such change of control contemplated by a public announcement or such a definitive agreement, in either case, is not consummated, or if an involuntary or constructive termination occurs later than 24 months following the change of control, such involuntary or constructive termination, as the case may be, shall not be a “change of control termination”. Under each executive severance agreement, a change of control occurs when: (I) any person becomes, pursuant to a transaction or a series of transactions not approved by the Ironwood board of directors, the beneficial owner, directly or indirectly, of Ironwood securities representing more than 50% of the total voting power; (II) a merger or consolidation of Ironwood occurs, whether or not approved by the Ironwood board of directors, which results in the holders of Ironwood'sIronwood’s voting securities holding less than 50% of the combined voting power of the surviving entity immediately after such merger or consolidation; (III) the sale or disposition of more than two-thirds of the assets of Ironwood; or (IV) the date a majority of members of the Ironwood board of directors is replaced during any 12-month period by directors whose appointment or election was not endorsed by a majority of members of the Ironwood board of directors before the date of the appointment or election.

Treatment of PSUs in the Event of a Change of Control

In the event of a change of control of Ironwood, the performance- and service-based vesting conditions applicable to the PSUs, to the extent then outstanding, will generally be treated as follows: the NDA Acceptance

2021  Proxy Statement    59


Table of Contents

GRAPHIC

2023 aTSR PSUs and Adjusted EBITDA2024 aTSR PSUs will become earned at the applicable target level (and subject to vesting as described below) as of immediately prior to the change of control provided that if the NDA Acceptance PSUs had already been earned at target as ofbased on the change of control no additional portion of such NDA Acceptancestock price. The 2022 rTSR PSUs, will become earned as a result of the change of control. The 20202023 rTSR PSUs and 2024 rTSR PSUs will become earned at target (and subject to vesting as described below) as of immediately prior to the change of control, provided that if the resulting rTSR percentile rank, determined after accounting for the stock price performance of Ironwood stock in connection with the change of control, would result in the 20202022 rTSR PSUs, 2023 rTSR PSUs or 2024 rTSR PSUs, as applicable, being earned above target, the 20202022 rTSR PSUs, 2023 rTSR PSUs or the 2024 rTSR PSUs, as applicable, will be deemed to be earned (and subject to vesting as described below) at such higher level in accordance with the terms of the award.

Any PSUs that become earned in connection with a change of control as described above shall vest in equal installments on a quarterly basis over the remaining portion of the applicable performance period, generally subject to a named executive officer'sofficer’s continued employment on each such vesting date. In the event of the occurrence of a qualifying termination in connection with or during the 24-month period immediately following the change of control and prior to the completion of the performance period, any earned but unvested PSUs held by the named executive officer will immediately vest in full in connection with such qualifying termination. If a named executive officer underwent a qualifying termination prior to a change of control, any outstanding PSUs held by the named executive officer as of the time of the change of control would become earned as described in the preceding paragraph but, in the case of the Adjusted EBITDA2022 rTSR PSUs, 2023 rTSR PSUs, 2024 rTSR PSUs, 2023 aTSR PSUs and the 2020 rTSR2024 aTSR PSUs remain subject to proration based on the number of days the named executive officer remained employed during the applicable performance period.


60   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Treatment of Equity in the Event of Death or Permanent Disability

For all employees, including our named executive officers, outstanding stock option and RSU awards subject solely to time-based vesting accelerate in full in the event of the death of the award holder. This term applies to all outstanding time-based stock option and RSU awards made under our equity incentive plans, including the 2019 Plan. Our current form of stock option and RSU agreements for awards issued under our 2019 Plan include similar provision for the acceleration of unvested time-based awards upon the death of an award holder, including our named executive officers.
In addition, the post-termination exercise window of all vested stock options held by a participant that were granted under our Amended and Restated 2010 Employee, Director and Consultant Equity Incentive Plan, 2019 Plan and Amended 2019 Plan, is extended to one year (or the stock option'soption’s final expiration date, if earlier) following the participant'sparticipant’s termination of employment by reason of his or her death.

With respect to PSUs, in the event of a termination of the named executive officer'sofficer’s employment as a result of his or her death or permanent disability, the awards, to the extent then outstanding, will not terminate and will remain eligible to vest based on the attainment of the applicable performance goals. Specifically, 2023 aTSR PSUs and 2024 aTSR PSUs will generally remain outstanding and eligible to vest based upon the NDA Acceptanceachievement of their respective 2023 aTSR or 2024 aTSR performance goals until the earlier of (A) the end of the performance period or (B) the 12-month period following the death or permanent disability with the number of PSUs actually delivered subject to proration based on the number of days the named executive officer remained employed during the applicable 2023 aTSR or 2024 aTSR performance period. The 2022 rTSR PSUs, 2023 rTSR PSUs or 2024 rTSR PSUs will generally remain outstanding and eligible to vest based upon the achievement of the NDA acceptance performance goal until the earlier of (A) the end of the performance period or (B) the twelve (12)-month period following the death or permanent disability. The Adjusted EBITDA PSUs and 2020 rTSR PSUs will generally remain outstanding and eligible to vest based upon the achievement of applicable performance goals until the end of the applicable rTSR performance period with the number of PSUs actually delivered subject to proration based on the number of days the named executive officer remained employed during the applicable rTSR performance period.

Employee Proprietary Information, Intellectual Property and Non-competition Agreements

Agreement

The employee proprietary information, intellectual property and non-competitionnoncompetition agreement that the company entered into with our former chief executive officerMessrs. Davis, Emany and Minardo provides that as consideration for entering into the noncompetition restrictions set forth in the eventsuch agreement, each of Messrs. Davis, Emany and Minardo will be eligible to participate in our 2019 Plan. The employee proprietary information, intellectual property and noncompetition agreement that the company determined to enforce the non-competition restriction included therein and a court determinedentered into with Mr. McCourt provides that such provision was

60    Ironwood


Table of Contents

GRAPHIC

unenforceable for lack of consideration, the company will provide for the payment of at least 50% of the former chief executive officer's highest annualized base salary in the last two years prior to the last day of our chief executive officer's employment for the length of the non-competition period as additional consideration for entering into the noncompetition restrictions set forth in such non-competition provisions.agreement, Mr. McCourt was eligible for cash incentive awards for performance in 2021. In addition, the employee proprietary information, intellectual property and non-competition agreementsnoncompetition agreement that the company entered into with Mr. McCourt and Dr. Shetzline provideprovides for an extended exercisability period for vested, unexercised nonqualified stock options for one year from the last date of employment in the event that the company determines to enforce the non-competition restriction included in such agreement.

2021


2024 Proxy Statement   61


Table of Contents

GRAPHIC

[MISSING IMAGE: hr_greenltsm-4c.jpg]

Potential Payments Upon Termination or Change of Control

Except as described in this proxy statement, there are currently no other agreements or arrangements pursuant to which our named executive officers would receive severance or other benefits in the event of a termination of employment or change of control of Ironwood. The following table presents our estimate of the amount of severance and other benefits to which our named executive officers would be entitled if a triggering event described below occurred on December 31, 2020.2023. The closing price of our Class A common stock as listed on the Nasdaq Global Select Market on December 31, 202029, 2023 was $11.39$11.44 per share. As described above, Mr. Mallon terminated employment on March 12, 2021 and, in connection with such termination, did not receive any severance benefits from the company.

[MISSING IMAGE: bc_line-4c.jpg]
Involuntary
Termination without
Cause or a Constructive
Termination(1)
Termination
Following a
Change of
Control(1)
Death(2)
Thomas McCourtCash Severance$1,251,315$1,668,420
Non-Equity Incentive Plan
Compensation
$1,564,144$1,876,973
Equity Acceleration(3)
RSUs$5,310,951$6,319,525$6,319,525
PSUs$7,078,866
Other Benefits(4)$74,871$79,828
Total$8,201,281$17,023,612$6,319,525
Sravan EmanyCash Severance$545,000$817,500
Non-Equity Incentive Plan
Compensation
$545,000$681,250
Equity Acceleration(3)
RSUs$1,335,460$1,335,460
PSUs$1,397,018
Other Benefits(4)$60,000$60,000
Total$1,150,000$4,291,228$1,335,460
Andew DavisCash Severance$480,000$720,000
Non-Equity Incentive Plan
Compensation
$480,000$600,000
Equity Acceleration(3)
RSUs$1,891,101$1,891,101
PSUs$875,011
Other Benefits(4)$87,429$101,143
Total$1,047,429$4,187,255$1,891,101
John MinardoCash Severance$512,728$769,092
Non-Equity Incentive Plan
Compensation
$461,455$576,819
Equity Acceleration(3)
RSUs$1,788,678$1,788,678
PSUs$2,066,121
Other Benefits(4)$69,238$73,857
Total$1,043,421$5,274,567$1,788,678
Michael Shetzline, M.D., Ph.D.Cash Severance(5)$800,343$800,343
Non-Equity Incentive Plan
Compensation
$480,206$600,257
Equity Acceleration(3)
RSUs$1,363,602$1,831,327$1,831,327
PSUs$1,994,587
Other Benefits(4)$60,000$60,000
Total$2,704,151$5,286,514$1,831,327

    Involuntary
Termination
without Cause or
a Constructive
Termination (1)
  Qualifying
Termination In
Connection with
or Following a
Change of
Control
  Death(2)
 

Mark Mallon

 Cash Severance $1,158,750 $1,545,000  

 Non-Equity Incentive Plan Compensation $1,448,438 $1,738,125  

 Equity Acceleration(4)    

     Options $41,942 $42,160 $42,160 

     RSUs $4,786,089 $5,178,088 $5,178,088 

     PSUs  $2,517,885  

 Other Benefits(5) $99,139 $112,185  

 Total $7,534,358 $11,133,442 $5,220,247 

Gina Consylman

 Cash Severance(3) $741,600 $741,600   

 Non-Equity Incentive Plan Compensation $494,400 $618,000   

 Equity Acceleration(4)          

     Options       

     RSUs $1,921,482 $2,242,759 $2,242,759 

     PSUs   $778,245   

 Other Benefits(5) $99,139 $99,139    

 Total $3,256,621 $4,479,743 $2,242,759 

Thomas McCourt

 Cash Severance(3) $834,600 $834,600  

 Non-Equity Incentive Plan Compensation $667,680 $834,600  

 Equity Acceleration(4)    

     Options    

     RSUs $2,568,992 $2,875,998 $2,875,998 

     PSUs  $1,144,490  

 Other Benefits(5) $74,144 $74,144  

 Total $4,145,416 $5,763,832 $2,875,998 

Jason Rickard

 Cash Severance(3) $685,125 $685,125   

 Non-Equity Incentive Plan Compensation $456,750 $570,938   

 Equity Acceleration(4)          

     Options       

     RSUs $1,598,040 $1,845,841 $1,845,841 

     PSUs   $686,692   

 Other Benefits(5) $57,094 $57,094   

 Total $2,797,009 $3,845,689 $1,845,841 

Michael Shetzline, M.D., Ph.D.

 Cash Severance(3) $672,075 $672,075  

 Non-Equity Incentive Plan Compensation $358,440 $448,050  

 Equity Acceleration(4)    

     Options    

     RSUs $1,020,066 $1,188,319 $1,118,319 

     PSUs  $556,686  

 Other Benefits(5) $53,766 $53,766  

 Total $2,104,347 $2,918,896 $1,188,319 
(1)

62    Ironwood


Table of Contents

GRAPHIC
(1)
Represents amounts payable under the terms of the named executive officer severance arrangements. Non-equity incentive plan compensation payment amount assumes no bonus amounts for 20202023 have been paid to the executive officer as of December 31, 2020,2023, and that all 20192022 bonus amounts have been paid as of such date, in each case, as would be consistent with Ironwood'sIronwood’s historical practice.


62   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
(2)
With respect to options, reflects the in-the-money value of the unvested portion of such named executive officer's options that have vesting provisions based solely on time, and not performance milestones, and that would be fully accelerated, in each case, in accordance with the terms of the award agreements issued under our equity incentive plans in connection with his or her death. The value is calculated by multiplying the amount (if any) by which $11.39, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020, exceeds the exercise price of the option by the number of shares subject to the accelerated portion of the option.



With respect to RSUs, the value is calculated by multiplying the number of unvested RSUs with vesting provisions based solely on time that would be fully accelerated (if any) in connection with the named executive officer'sofficer’s death by $11.39,$11.44, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020,29, 2023, in accordance with the terms of the award agreements issued under our equity incentive plans.


With respect to PSUs, the treatment of such awards in the event of the named executive officer'sofficer’s death or permanent disability is described elsewhere in this proxy statement under the caption Treatment of Equity in the Event of Death or Permanent Disability and in footnote 4 to this table.

(3)

With respect to RSUs, the value is calculated by multiplying the number of unvested RSUs with vesting provisions based solely on time that would be accelerated (if any) by $11.44, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 29, 2023, in each case, in accordance with the terms of our severance arrangements with each executive officer.
With respect to PSUs, the value in the case of a qualifying termination in connection with a change of control is calculated by multiplying the number of unvested and unearned PSUs that would be accelerated (if any) by $11.44, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 29, 2023, as described in further detail above under the caption Treatment of PSUs in the Event of a Change of Control. In the case of a qualifying termination or death prior to a change in control, the PSUs will remain eligible to vest based on the attainment of the applicable performance goals, subject to applicable proration, as described above under the captions Severance Benefits not in Connection with a Change of Control and Treatment of Equity in the Event of Death or Permanent Disability. The values in this table include the 2021 rTSR PSUs, for which the performance period ended on December 31, 2023, at 100% of target as the PSUs became earned at 100% of the target, with such earned PSUs vesting amount certified by the compensation and HR committee on January 17, 2024. The values in this table assume that the 2022 rTSR PSUs and 2023 rTSR PSUs will become earned at 100% based on their actual TSR as of December 31, 2023, and that the 2023 aTSR PSUs remain unearned based on actual stock price performance as of December 31, 2023.
(4)
Includes outplacement assistance benefits and subsidized COBRA benefits. With respect to an involuntary termination without cause or a constructive termination, includes the value of the payment of an additional amount equal to six months of subsidized COBRA benefits for Dr. Shetzline in the event he is not eligible to participate in the group medical plan of another employer following the one-year anniversary of his termination date.
(5)
With respect to an involuntary termination of employment without cause or a constructive termination, includes the value of the payment of an additional amount equal to six months of base salary for all named executive officers (other than Mr. Mallon)Dr. Shetzline in the event he or she does not obtain full-time employment within six months following the one yearone-year anniversary of his or her termination date.

(4)
With respect to options, reflects the in-the-money value of the unvested portion of such named executive officer's options that have vesting provisions based solely on time, and not performance milestones, and that would be accelerated, in each case, in accordance with the terms of our severance agreements with each executive officer. The value is calculated by multiplying the amount (if any) by which $11.39, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020, exceeds the exercise price of the option by the number of shares subject to the accelerated portion of the option.



With respect to RSUs, the value is calculated by multiplying the number of unvested RSUs with vesting provisions based solely on time that would be accelerated (if any) by $11.39, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020, in each case, in accordance with the terms of our severance arrangements with each executive officer.


With respect to PSUs, the value in the case of a change of control termination is calculated by multiplying the number of unvested and unearned PSUs that would be accelerated (if any) by $11.39, the closing price of our Class A common stock on the Nasdaq Global Select Market on December 31, 2020, as described in further detail above under the caption Treatment of PSUs in the Event of a Change of Control. In the case of a qualifying termination or death prior to a change of control, the PSUs will remain eligible to vest based on the attainment of the applicable performance goals, subject to applicable proration, as described above under the captions Severance Benefits not in Connection with a Change of Control and Treatment of Equity in the Event of Death or Permanent Disability. The values in this table assume that the PSUs will become earned at target.

(5)
Includes outplacement assistance benefits and subsidized COBRA benefits. With respect to involuntary termination without cause or a constructive termination, includes the value of the payment of an additional amount equal to six months of subsidized COBRA benefits for all named executive officers (other than Mr. Mallon) in the event he or she is not eligible to participate in the group medical plan of another employer following the one year anniversary of his or her termination date.

2021


2024 Proxy Statement   63


Table of Contents

GRAPHIC

[MISSING IMAGE: hr_greenltsm-4c.jpg]

CEO Pay Ratio

Under the Dodd-Frank Wall Street Reform and Consumer Protection Act, we are required to disclose the median of the annual total compensation of our employees, the annual total compensation of our principal executive officer on December 31, 2020,2023, Mr. Mallon,McCourt, and the ratio of these two amounts. For 2020,2023, our last completed fiscal year:


The estimated median of the annual total compensation of all employees of our company (other than Mr. Mallon)McCourt) was $222,011;$275,531; and


Mr. Mallon'sMcCourt’s annual total compensation, as reported in the Summary Compensation Table included elsewhere in this proxy statement, was $6,821,113.

$7,583,270.

Based on this information for 2020,2023, we estimate that the ratio of the annual total compensation of Mr. MallonMcCourt to the median annual total compensation of all employees was approximately 3128 to 1. We believe this pay ratio is a reasonable estimate calculated in a manner consistent with SEC rules based on our payroll and employment records, and the methodology described below. Because the SEC rules for identifying the median of the annual total compensation of our employees and calculating the pay ratio based on that employee'semployee’s annual total compensation allow companies to adopt a variety of methodologies, to apply certain exclusions, and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices, the pay ratio reported by other companies may not be comparable to the pay ratio for Ironwood, as other companies have employees based in different locations (including other countries), have different business models and employee needs, have different employee populations and compensation practices and may utilize different methodologies, exclusions, estimates and assumptions in calculating their pay ratios.

To identify the median of the annual total compensation of all our employees, as well as to determine the annual total compensation of our median employee and Mr. Mallon,McCourt, we took the following steps:


We determined that it was appropriate to re-identify our median employee for the purposes of the pay ratio disclosure for 2020.2023. We determined that, as of December 31, 2020,2023, our employee population consisted of 305 individuals.216 individuals, excluding 44 individuals who joined Ironwood as a result of our acquisition of VectivBio Holding AG in 2023. This population consisted of our full- and part-time employees. We utilized a December 31, 20202023 identification date as it is consistent with our CEO pay ratio reporting last year, our year-end financial reporting, and other reporting dates used in this proxy statement. The year-end identification date enables us to make such identification in a reasonably efficient and economical manner.


To identify the "median employee"“median employee” from our employee population, we started with the gross earnings of our employees as reflected in our payroll records for 20202023 as of the identification date, and, for our U.S. employees, as reportable to the Internal Revenue Service on Form W-2. We subtracted 20202023 equity earnings from stock option exercises and stock award vesting and replaced them with the grant-date fair value of equity awards granted in 2020.2023. We subtracted 20192022 annual bonuses (paid in 2020)2023) and replaced them with 20202023 annual bonus awards (paid in 2021)2024). We also added the company'scompany’s 401(k) matching contribution.contribution for our U.S. employees. For employees hired during 2020,2023, we annualized base salary and 20202023 bonus amounts, but not the value of equity granted in 20202023 as new hire awards are made on a one-time basis.

We did not make any cost-of-living adjustments in identifying the "median“median employee."

Once we identified the median employee, for purposes of the pay ratio, we calculated his or her compensation in the same manner as we do for Summary Compensation Table purposes.

64   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Pay Versus Performance
Under Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(v) of Regulation S-K, we are presenting information that demonstrates the relationship between compensation actually paid, as computed under SEC rules, to our named executive officers and certain financial performance measures for the years ended December 31, 2023, 2022, 2021 and 2020. The compensation and HR committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the fiscal years shown. For additional information about our performance-based pay philosophy and how we align executive compensation with Ironwood’s performance, please refer to the Compensation Discussion and Analysis section included elsewhere in this proxy statement.
[MISSING IMAGE: bc_line-4c.jpg]
YearSummary
Compensation
Table Total
for First PEO
[Mark Mallon]
Summary
Compensation
Table Total
for Second PEO
[Thomas
McCourt]
Compensation
Actually
Paid to
First PEO
[Mark Mallon]
Compensation
Actually
Paid to
Second PEO
[Thomas
McCourt]
Average
Summary
Compensation
Table Total
for Non-PEO
NEOs
Average
Compensation
Actually
Paid to
Non-PEO
NEOs
Value of Initial Fixed $100
Investment Based On:
Net Income
(Loss)
(in millions)
Adjusted
EBITDA from
Organic Business
(in millions)
Total
Shareholder
Return
Peer Group
Total
Shareholder
Return
(a)(b)(1)(b)(1)(c)(2)(c)(2)(d)(3)(e)(4)(f)(5)(g)(6)(h)(7)(i)(8)
2023$N/A$7,583,270$N/A$4,632,286$2,615,301$1,967,644$85.95$115.42$(1,031.56)$267.64
2022$N/A$7,893,266$N/A$10,159,660$2,305,695$2,952,674$93.09$111.27$175.07$253.07
2021$170,576$8,810,004$(8,684,142)$9,733,970$2,917,054$2,581,189$87.60$124.89$528.45$253.97
2020$6,821,113$N/A$4,419,700$N/A$2,496,976$2,958,190$85.57$125.69$106.18$162.56
(1)
The dollar amounts reported in column (b) are the amounts of total compensation reported for Mr. Mallon, our former chief executive officer, and Mr. McCourt, our current chief executive officer, for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to Summary Compensation Table elsewhere in this proxy statement for information on Mr. McCourt’s compensation. Mr. Mallon served as our chief executive officer during 2020 and 2021. Effective March 12, 2021, Mr. Mallon resigned from his position as chief executive officer and Mr. McCourt became interim chief executive officer and subsequently permanent chief executive officer effective June 2, 2021.
(2)
The dollar amounts reported in column (c) represent the “compensation actually paid” to the principal executive officers, or PEOs, Messrs. Mallon and McCourt, as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid to Messrs. Mallon and McCourt, as applicable, during the applicable years, and are based on valuation assumptions required by the SEC, which are unlikely to reflect actual amounts realized at vesting or exercise of equity awards, as applicable. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to Messrs. Mallon’s and McCourt’s total compensation for each applicable year to determine the compensation actually paid:
[MISSING IMAGE: bc_line-4c.jpg]
YearPEO NameReported
Summary
Compensation
Table Total
for PEO
Reported
Value of
Equity
Awards
(a)
Equity Award
Adjustments
(b)
Compensation
Actually
Paid to PEO
2023Thomas McCourt$7,583,270$(5,974,225)$3,023,271$4,632,286
2022Thomas McCourt$7,893,266$(6,473,069)$8,739,463$10,159,660
2021Mark Mallon$170,576$$(8,854,718)$(8,684,142)
2021Thomas McCourt$8,810,004$(7,236,498)$8,160,464$9,733,970
2020Mark Mallon$6,821,113$(5,423,731)$3,022,318$4,419,700
(a)
Represents the deduction from the “Reported Summary Compensation Table purposes.

    With respect toTotal for PEO” column for the annual total compensationgrant date fair value of our CEO, we used the amountequity awards reported in the "Total"“Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year.
(b)
The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year; (ii) the amount of change as of the end of the applicable year (from the end of the prior year) in fair value of any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (iii) for awards that are granted and vest in the same applicable year, the fair

2024 Proxy Statement   65

[MISSING IMAGE: hr_greenltsm-4c.jpg]
value as of the vesting date; (iv) for awards granted in prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. Equity values are calculated in accordance with ASC 718. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. The amounts deducted or added in calculating the equity award adjustments are as follows:
[MISSING IMAGE: bc_line-4c.jpg]
YearPEO NameYear End
Fair Value
of Equity
Awards
Year over
Year Change
in Fair Value
of Outstanding
and Unvested
Equity Awards
Fair Value as
of Vesting
Date of Equity
Awards
Granted and
Vested in
the Year
Year over Year
Change in Fair
Value of
Equity Awards
Granted in
Prior Years
that Vested in
the Year
Fair Value at
the End of the
Prior Year of
Equity
Awards that
Failed to
Meet Vesting
Conditions in
the Year
Value of
Dividends or
Other Earnings
Paid on Stock
or Option
Awards not
Otherwise
Reflected in
Fair Value
or Total
Compensation
Total Equity
Award
Adjustments
2023Thomas McCourt$6,203,423$(2,858,574)$(321,578)$$3,023,271
2022Thomas McCourt$7,807,002$1,076,844$(144,383)$$8,739,463
2021Mark Mallon$$$(241,452)$(8,613,266)$(8,854,718)
2021Thomas McCourt$8,164,222$57,645$(61,403)$$8,160,464
2020Mark Mallon$4,811,824$(1,031,283)$(758,223)$$3,022,318
(3)
The dollar amounts reported in column (d) represent the average of the amounts reported for the company’s non-PEO named executive officers, or NEOs, as a group in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the non-PEO NEOs included for 2020.purposes of calculating the average amounts in each applicable year are as follows: (i) for 2023, Andrew Davis, Sravan Emany, John Minardo and Michael Shetzline; (ii) for 2022, Sravan Emany, John Minardo, Jason Rickard and Michael Shetzline; (iii) for 2021, Sravan Emany, John Minardo, Jason Rickard, Michael Shetzline and Gina Consylman; and (iv) for 2020, Gina Consylman, Thomas McCourt, Jason Rickard and Michael Shetzline.

64    Ironwood


[MISSING IMAGE: bc_line-4c.jpg]
YearAverage
Reported
Summary
Compensation
Table Total for
Non-PEO NEOs
Average
Reported Value
of Equity Awards
(a)
Average
Equity Award
Adjustments
(b)
Compensation
Actually Paid to
Non-PEO NEOs
2023$2,615,301$(1,762,026)$1,114,369$1,967,644
2022$2,305,695$(1,531,837)$2,178,816$2,952,674
2021$2,917,054$(2,332,567)$1,996,702$2,581,189
2020$2,496,976$(452,817)$914,031$2,958,190
(a)
Represents the deduction from the “Average Reported Summary Compensation Table Total for Non-PEO NEOs” column for the average total grant date fair value of Contents

equity awards reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year.

GRAPHIC
66   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
(b)
The amounts deducted or added in calculating the total average equity award adjustments are as follows:

Compensation Committee Report

We have:

1.
reviewed
[MISSING IMAGE: bc_line-4c.jpg]
YearAverage
Year End
Fair Value
of Equity
Awards
Year over
Year Average
Change
in Fair Value
of Outstanding
and Unvested
Equity Awards
Average Fair
Value as
of Vesting
Date of Equity
Awards
Granted and
Vested in the
Year
Year over
Year Average
Change in Fair
Value of
Equity Awards
Granted in
Prior Years
that Vested in
the Year
Average Fair
Value at
the End of the
Prior Year of
Equity
Awards that
Failed to
Meet Vesting
Conditions in
the Year
Average
Value of
Dividends or
Other Earnings
Paid on Stock
or Option
Awards not
Otherwise
Reflected in
Fair Value
or Total
Compensation
Total
Average
Equity
Award
Adjustments
2023$1,829,617$(633,278)$(81,970)$1,114,369
2022$1,880,771$329,381$(31,337)$2,178,816
2021$2,563,358$(434)$(52,032)$(514,190)$1,996,702
2020$1,512,719$(402,588)$(196,100)$914,031
(5)
Cumulative TSR is calculated by dividing (i) the sum of (A) the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and discussed(B) the difference between Ironwood’s share price at the end and the beginning of the measurement period, by (ii) Ironwood’s share price at the beginning of the measurement period.
(6)
Represents the weighted peer group TSR, weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. The peer group used for this purpose is the Nasdaq Biotechnology Index, our peer group used for purposes of Item 201(e) of Regulation S-K.
(7)
The dollar amounts reported represent the amount of net income (loss) reflected in our audited financial statements for the applicable year. Net income for the year ended December 31, 2021 included a $338 million non-cash, non-recurring income tax benefit related to the release of the valuation allowance against the majority of the company’s deferred tax assets in the second quarter of 2021. Net loss for the year ended December 31, 2023, included a non-recurring charge of approximately $1.1 billion related to acquired in-process research and development from the acquisition of VectivBio in the second quarter of 2023.
(8)
As required by Item 402(v) of Regulation S-K, we have determined that Adjusted EBITDA from organic business is the Company Selected Measure, as it is the most important financial performance measure (that is not otherwise required to be disclosed in the table) used to link compensation actually paid to our NEOs to company performance for the most recently completed year. Adjusted EBITDA from organic business, which is a non-GAAP measure, is calculated by subtracting mark-to-market adjustments on derivatives related to the company’s 2022 convertible senior notes, restructuring expenses, net interest expense, income taxes, depreciation and amortization, revenue and expenses related to corporate development activities, and costs associated with managementa potential CNP-104 option exercise from GAAP net income. This metric and definition is consistent with Adjusted EBITDA from organic business used in the corporate performance goals scorecard, as described in the Compensation Discussion and Analysis found herein; and

2.
based on included elsewhere in this proxy statement. We may change the review and discussions referredCompany Selected Measure from year to year, depending upon a number of factors relating to our business.
Comparative Analysis of the Pay versus Performance Table
As described in paragraph (1) above, we recommended tomore detail in the board of directors that the Compensation Discussion and Analysis be section included elsewhere in this proxy statement, our compensation program is designed to provide compensation and incentives that align employee actions and motivations with the interests of our stockholders; attract, retain, motivate, and reward outstanding talent across the company through well-communicated programs that are aligned with our vision and mission, and support a positive company culture. We consider several performance measures to ensure executives are incentivized to accomplish these objectives, many of which are not presented in the company'spay versus performance table. In accordance with Item 402(v) of Regulation S-K, we are providing the following descriptions of the relationships between information presented in the Pay versus Performance Table above.

2024 Proxy Statement   67

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Comparison of Ironwood Cumulative TSR to Peer Group Cumulative TSR
The graph below shows our cumulative TSR over the four-year period ending December 31, 2023, as compared to the Nasdaq Biotechnology Index, which reflects the company’s industry sector and is also the peer group used in our Annual Report on Form 10-K.
[MISSING IMAGE: lc_index-4c.jpg]
Comparison of  “Compensation Actually Paid” to Cumulative TSR
The “compensation actually paid” in the graph below reflects Mr. Mallon’s CAP in 2020, Mr. McCourt’s CAP in 2022 and 2023, and, for purposes of a graphical representation, a weighted average CAP for both for 2021, or Average PEO CAP. The graph below demonstrates the “compensation actually paid” amounts shown for our PEOs, Messrs. Mallon and McCourt, as applicable, is generally aligned with the company’s cumulative TSR over the four years presented in the Pay versus Performance Table above. The alignment of compensation actually paid with the company’s cumulative TSR over the period presented is because a significant portion of the compensation actually paid to the NEOs is comprised of equity awards. As described in more detail in the Compensation Discussion and Analysis section included elsewhere in this proxy statement, on Schedule 14A for filing within 2023, approximately 79% of the SEC.value of total compensation awarded to our CEO and 68% of the value of total compensation awarded to the other NEOs consists of equity awards, including RSU and PSU awards.
[MISSING IMAGE: bc_tsr-4c.jpg]

68   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Comparison of  “Compensation Actually Paid” to Net Income (Loss)
The graph below reflects the relationship between the Average PEO CAP and average other NEOs CAP and the company’s net income for the years ended December 31, 2020, 2021, 2022 and 2023. Net income for the year ended December 31, 2021, included a $338 million non-cash, non-recurring income tax benefit related to the release of the valuation allowance against the majority of the company’s deferred tax assets in the second quarter of 2021. Net loss for the year ended December 31, 2023, included a non-recurring charge of approximately $1.1 billion related to acquired in-process research and development from the acquisition of VectivBio in the second quarter of 2023. The company does not use net income as a performance metric in its compensation program to determine named executive officers’ compensation.
[MISSING IMAGE: bc_netincome-4c.jpg]

2024 Proxy Statement   69

[MISSING IMAGE: hr_greenltsm-4c.jpg]
Comparison of  “Compensation Actually Paid” to Company-Selected Measure (Adjusted EBITDA from Organic Business)
The graph below reflects the relationship between the Average PEO CAP and average Other NEOs CAP and the company’s Adjusted EBITDA from organic business, which is the Company Selected Measure, for the years ended December 31, 2020, 2021, 2022 and 2023:
[MISSING IMAGE: bc_ebitda-4c.jpg]

70   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Company Performance Metrics
As described in more detail in the Compensation Discussion and Analysis section included elsewhere in this proxy statement, the performance measures we use in our compensation program are weighted toward long-term equity incentive compensation as opposed to short-term or cash-based compensation. We believe this better aligns the interests of our named executive officers and our stockholders and serves to focus further our named executive officers on the creation of long-term stockholder value. As required by Item 402(v) of Regulation S-K, we have identified the following financial performance measures as being the most important in linking actual compensation paid to executives to our performance.
[MISSING IMAGE: bc_line-4c.jpg]
Most Important Performance Measures


Adjusted EBITDA from Organic Business

By the Compensation and HR Committee,


LINZESS U.S. Net Sales

Andrew Dreyfus, Chair
Jon R. Duane
Marla L. Kessler
Revenue
Total Stockholder Return

2021


2024 Proxy Statement   65


Table of Contents

GRAPHIC


Table of Contents

GRAPHIC 71

[MISSING IMAGE: cv_ibc-4c.jpg]
PROPOSAL No. 2
Advisory Vote
on Named
Executive Officer
Compensation

Proposal No. 2

[MISSING IMAGE: ic_check-pn.gif]
OUR BOARD RECOMMENDS THAT YOU
APPROVE THE COMPENSATION OF
OUR NAMED EXECUTIVE OFFICERS AS DISCLOSED IN THIS PROXY STATEMENT

[MISSING IMAGE: ic_prop2-bw.gif]

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Proposal No. 2
At our 20212024 annual meeting, we are providing our stockholders with the opportunity to cast an advisory (non-binding) vote on named executive officer compensation, or a "say-on-pay"“say-on-pay” vote. This is a non-binding vote on the compensation of our "named“named executive officers," as described in the Compensation Discussion and Analysis section, the tabular disclosure regarding such compensation, and the accompanying narrative disclosure, all as set forth in this proxy statement.

The objectiveobjectives of our compensation policies isare to provide compensation and incentives that align employee actions and motivations with the interests of our stockholders; attract, retain, motivate and reward outstanding talent across Ironwood through well-communicated programs that are aligned with our vision and mission; and support a positive company culture. In 2020,2023, the compensation program for our named executive officers consisted principally of base salary, cash bonus and long-term equity incentive compensation in the form of performance-based restricted stock units and restricted stock units. While we offer reasonably competitive base salaries and cash bonuses, our compensation program is weighted toward long-term equity incentive compensation as opposed to short-term or cash-based compensation. We believe this better aligns the interests of our named executive officers and our stockholders and serves to further focus our named executive officers on the creation of long-term stockholder value. If we achieve our corporate goals over the long term, we expect our stock price to reflect our performance and the equity awards currently held by our named executive officers to become an even more significant component of overall compensation. Our compensation and HR committee and board believes that this approach to executive compensation links compensation directly to continuous improvements in corporate performance and, ultimately our stock price, and demonstrates our "pay“pay for performance"performance” compensation philosophy.

Our previous say-on-pay vote was at our 20202023 annual meeting and was approved by approximately 84%98% of the votes cast on such matter. Under the Dodd-Frank Wall Street Reform and Consumer Protection Act, as well as the provisions of Section 14A of the Exchange Act, we must hold the advisory (non-binding) vote on named executive officer compensation at least once every three years. Based on the recommendation of our stockholders in 2017,2023, our board of directors determined to provide our stockholders the opportunity to vote (on an advisory basis) on named executive officer compensation on an annual basis to allow our stockholders to provide us with regular, timely and direct input on our executive compensation philosophy, policies and practices as disclosed in the proxy statement each year. We believe this practice allows us to further align our compensation programs with our stockholders'stockholders’ interests as stockholder feedback may be taken into consideration as part of the compensation review process.

Vote Required

Because this proposal seeks a non-binding, advisory vote, there is no "required vote"“required vote” that would constitute approval. However, our board of directors, including our compensation and HR committee, values the opinions of our stockholders and, to the extent there are a substantial number of votes cast against the executive officer compensation as disclosed in this proxy statement, we will consider our stockholders'stockholders’ concerns and evaluate which actions may be appropriate to address those concerns. Broker nominees do not have discretion to vote on this proposal without your instruction; if you do not instruct your broker nominee how to vote on this proposal, your broker nominee will not vote your shares with respect to this proposal. Any shares that are not voted, whether by abstention, broker non-votes or otherwise, will not affect the outcome of this proposal.

2021


2024 Proxy Statement   67


Table of Contents

73

[MISSING IMAGE: htr_bluegreen-4c.jpg]
Our Stockholders

Security Ownership of Certain Beneficial Owners and Management

The following table sets forth certain information with respect to the beneficial ownership of our Class A common stock at March 31, 20212024 for:


each person whom we know beneficially owns more than five percent of our Class A common stock;


each of our directors;


each of our named executive officers; and


all of our current directors and executive officers as a group.

The number of shares beneficially owned by each stockholder is determined under rules issued by the SEC. Under these rules, beneficial ownership includes any shares as to which the individual or entity has sole or shared voting power or investment power. Each of the stockholders listed has sole voting and investment power with respect to the shares beneficially owned by the stockholder unless noted otherwise, subject to community property laws where applicable.

The percentage of Class A common stock beneficially owned by each person is based on 161,931,012158,957,123 shares of Class A common stock outstanding on March 31, 2021.2024. Shares of Class A common stock that may be acquired within 60 days following March 31, 20212024, pursuant to the exercise of options or the vesting of RSUs, are included in the holdings of each stockholder, as applicable, and are deemed to be outstanding for the purpose of computing the percentage ownership of such holder. Such amounts, however, are not included in the holdings of any other stockholder in the table below and are not deemed to be outstanding for computing the percentage ownership of any other holder shown in the table below. Beneficial ownership representing less than one percent is denoted with an "*“*."

68    Ironwood


Table of Contents


GRAPHIC
74   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]

Unless otherwise indicated, the address for each of the stockholders in the table below is c/o Ironwood Pharmaceuticals, Inc., 100 Summer Street, Suite 2300, Boston, Massachusetts 02110.

[MISSING IMAGE: bc_line-4c.jpg]
Name of Beneficial OwnerNumber of Shares
of our Class A
Common Stock
Percentage
Named Executive Officers and Directors
Thomas McCourt(1)1,621,3261.0%
Sravan Emany(2)175,364*
Andrew Davis(3)128,539*
John Minardo(4)134,540*
Michael Shetzline, M.D., Ph.D.(5)360,430*
Mark Currie, Ph.D.(6)993,377*
Alexander Denner, Ph.D.(7)16,511,93910.3%
Andrew Dreyfus163,919*
Jon Duane121,028*
Marla Kessler96,572*
Julie McHugh162,294*
Catherine Moukheibir128,633*
Jay Shepard102,244*
All executive officers and directors as a group (13 persons)(8)20,700,20512.9%
5% Security Holders
BlackRock, Inc.(9)25,978,89916.3%
Sarissa Capital Management LP(10)16,390,00010.3%
The Vanguard Group(11)16,033,54510.1%
State Street Corporation(12)11,532,0887.3%

Name of Beneficial Owner

  Number of Shares
of our Class A
Common Stock
 Percentage

Named Executive Officers and Directors

    

Mark Mallon(1)

  449,356 *

Gina Consylman(2)

 363,076 *

Thomas McCourt(3)

  1,201,420 *

Jason Rickard(4)

 306,016 *

Michael Shetzline, M.D., Ph.D.(5)

  72,505 *

Mark G. Currie, Ph.D.(6)

 1,352,404 *

Andrew Dreyfus

  109,097 *

Jon R. Duane

 47,421 *

Marla L. Kessler

  47,421 *

Julie H. McHugh

 125,607 *

Catherine Moukheibir

  48,994 *

Lawrence S. Olanoff, M.D., Ph.D.

 68,629 *

Edward P. Owens

  218,954 *

Alexander J. Denner, Ph.D.(7)

 16,429,079 10.1%

Jay P. Shepard

  35,557 *

All current executive officers and directors as a group (14 persons)(8)

 20,426,180 12.6%
​ ​ 

5% Security Holders

     

Wellington Management Group LLP(9)

 21,653,549 13.4%

Brown Capital Management, LLC(10)

  20,150,463 12.4%

Sarissa Capital Management LP(11)

 16,390,000 10.1%

The Vanguard Group(12)

  15,892,347 9.8%

BlackRock, Inc.(13)

 13,044,650 8.1%

Westfield Capital Management Company, LP(14)

  8,488,043 5.2%
(1)
(1)
Includes 333,547 shares of Class A common stock issuable to Mr. Mallon upon the exercise of options that are exercisable within 60 days following March 31, 2021.

(2)
Includes 249,747 shares of Class A common stock issuable to Ms. Consylman upon the exercise of options that are exercisable within 60 days following March 31, 2021.

(3)
Includes (i) 1,094,1501,015,664 shares of Class A common stock issuable to Mr. McCourt upon the exercise of options that are exercisable within 60 days following March 31, 2021 and2024, (ii) 5,71326,172 restricted stock units that vest on May 20, 2021.

(4)
Includes (i) 171,60016, 2024, and (iii) 120,298 performance-based restricted stock units for which shares of Class A common stock issuable to Mr. Rickard upon the exercise of options that are exercisablewere vested and will be delivered within 60 days following March 31, 20212024.
(2)
Includes 37,120 performance-based restricted stock units for which shares were vested and (ii) 1,714will be delivered within 60 days following March 31, 2024.
(3)
Includes (i) 20,000 restricted stock units that vest on May 20, 2021.

16, 2024, and (ii) 37,120 performance-based restricted stock units for which shares were vested and will be delivered within 60 days following March 31, 2024.
(4)
Includes 32,752 performance-based restricted stock units for which shares were vested and will be delivered within 60 days following March 31, 2024.
(5)

Includes (i) 54,07492,698 shares of Class A common stock issuable to Dr. Shetzline upon the exercise of options that are exercisable within 60 days following March 31, 20212024, and (ii) 6,91434,936 performance-based restricted stock units that vest on May 20, 2021.

2021  Proxy Statement    69


Table of Contents

GRAPHIC for which shares were vested and will be delivered within 60 days following March 31, 2024.
(6)
(6)
Includes 824,582449,269 shares of Class A common stock issuable to Dr. Currie upon the exercise of options that are exercisable within 60 days following March 31, 2021.

2024.

2024 Proxy Statement   75

[MISSING IMAGE: hr_greenltsm-4c.jpg]
(7)

Includes (i) 39,079121,939 shares of Class A common stock held directly by Dr. Denner, and (ii) 16,390,000 shares of Class A common stock held by Sarissa Capital Management LP, or Sarissa. See note 1110 below for information regarding the shares of Class A common stock held by Sarissa.

(8)

Includes (i) 2,394,4231,557,631 shares of Class A common stock issuable upon the exercise of options that are exercisable within 60 days following March 31, 2021 and2024, (ii) 14,34146,172 restricted stock units that vest on May 20, 2021.

16, 2024, and (iii) 262,226 performance-based restricted stock units for which shares were vested and will be delivered within 60 days following March 31, 2024.
(9)

Based upon the information provided by Wellington Management Group LLP,BlackRock, Inc., or Wellington, Wellington Group Holdings LLP, or Wellington Group, Wellington Investment Advisors Holdings LLP, or Wellington Investment, and Wellington Management Company LLP, or Wellington Management and, collectively with Wellington, Wellington Group and Wellington Investment, the Wellington Entities,BlackRock, in a Schedule 13G/A filed on February 4, 2021,January 22, 2024, reporting as of December 31, 2020.2023. According to this Schedule 13G/A, (i) Wellington does not have sole voting or sole dispositive power with respect to any of these shares, and has shared voting power with respect to 20,061,000 of these shares and shared dispositive power with respect to all of these shares, (ii) Wellington Group does not have sole voting or sole dispositive power with respect to any of these shares, and has shared voting power with respect to 20,061,000 of these shares and shared dispositive power with respect to all of these shares, (iii) Wellington Investment does not have sole voting or sole dispositive power with respect to any of these shares, and has shared voting power with respect to 20,061,000 of these shares and shared dispositive power with respect to all of these shares, and (iv) Wellington Management does not have sole voting or sole dispositive power with respect to any of these shares, and has shared voting power with respect to 19,476,837 of these shares and shared dispositive power with respect to 19,509,866 of these shares. The address of the Wellington Entities is c/o Wellington Management Company LLP, 280 Congress Street, Boston, MA 02210.

(10)
Based upon the information provided by Brown Capital Management, LLC, or Brown Capital, and The Brown Capital Management Small Company Fund, or Brown Capital Small Fund and, collectively with Brown Capital, the Brown Capital Entities, in a Schedule 13G/A filed on February 12, 2021, reporting as of December 31, 2020. According to this Schedule 13G/A, (i) Brown CapitalBlackrock has sole voting power with respect 12,680,378to 25,253,721 of these shares, and a sole dispositive power with respect toover all of these shares, andshares. Blackrock does not have shared voting power or shared dispositive power with respect to any of these shares, and (ii) Brown Capital Small Fund has sole voting and sole dispositive power with respect to 9,980,218 of these shares and does not have shared voting ornor shared dispositive power with respect to any of these shares. The address of the Brown Capital EntitiesBlackRock is 1201 N. Calvert Street, Baltimore, MD 21202.

(11)
50 Hudson Yards, New York, NY 10001.
(10)
Based upon the information provided by Sarissa and Dr. Denner in a Schedule 13D/A filed on March 1, 2021, reporting as of February 26, 2021, as well as a Form 4 filed on March 10, 2021,19, 2024, reporting as of March 10, 2021.15, 2024. According to this Schedule 13D/A, (i) Sarissa does not have sole voting or sole dispositive power with respect to any of these shares and has shared voting and shared dispositive power with respect to all of these shares, and (ii) Dr. Denner does not have sole voting or sole dispositive power with respect to any of these shares and has shared voting and shared dispositive power with respect to all of these shares. Does not include shares held directly by Dr. Denner, who is a member of our board of directors. The address of each of Sarissa and Dr. Denner is 660 Steamboat Road, Greenwich, CT 06830.

(12)
(11)
Based upon the information provided by The Vanguard Group, or Vanguard, in a Schedule 13G/A filed on FebruaryJanuary 10, 2021,2024, reporting as of December 31, 2020.2023. According to this Schedule 13G/A, Vanguard does not have sole voting power with respect to any of these shares, and has sole dispositive power with respect to 15,368,03515,711,058 of these shares, shared voting power with respect to 373,334163,827 of these shares, and shared dispositive power with respect to 524,312322,487 of these shares. The address of Vanguard is 100 Vanguard Blvd., Malvern, PA 19355.

(13)
(12)
Based upon the information provided by BlackRock, Inc.,State Street Corporation, or BlackRock,State Street, in a Schedule 13G/A filed on January 29, 2021,25, 2024, reporting as of December 31, 2020.2023. According to this Schedule 13G/A, BlackrockState Street does not have sole voting or sole dispositive power with respect to any of these shares, has soleshared voting power with respect to 12,844,04111,117,328 of these shares soleand has shared dispositive power with respect to all of these shares, and does not have shared voting or shared dispositive power with respect to any of these shares. The address of BlackRockState Street is 55 East 52ndState Street New York, NY 10055.

(14)
Based upon the information provided by Westfield Capital Management Company, LP, or Westfield, in a Schedule 13G filed on January 7, 2021, reporting as of December 31, 2020. According to this Schedule 13G, Westfield has sole voting power with respect to 7,660,852 of these shares, sole dispositive power with respect to all of these shares, and does not have shared voting or shared dispositive power with respect to any of these shares. The address of Westfield is 1 Financial Center, 1 Lincoln Street, Boston, MA 02111.

70    Ironwood


Table of Contents

GRAPHIC
76   Ironwood

[MISSING IMAGE: htr_greenorange-4c.jpg]
Certain Relationships and
Related
Person Transactions

Since January 1, 2020,2023, except as described below, there has not been, nor is there currently proposed, any transaction or series of similar transactions to which we were or are a party in which the amount involved exceeded or exceeds $120,000 and in which any of our directors, executive officers, holders of more than 5% of any class of our voting securities, or any member of the immediate family of any of the foregoing persons, had or will have a direct or indirect material interest, other than compensation arrangements with directors and executive officers, which, with respect to our directors and named executive officers are described under the captions Our Board of Directors—Directors — How We AreOur Board is Paid and Executive Compensation appearing elsewhere in this proxy statement.

Indemnification Agreements

Indemnification Agreements

We have entered into indemnification agreements with each of our current directors and certain of our executive officers. These agreements require us to indemnify these individuals to the fullest extent permitted under the General Corporation Law of the State of Delaware law against liabilities that may arise by reason of their service to us and to advance expenses incurred as a result of any proceeding against them as to which they could be indemnified. We intend to enter into indemnification agreements with our future directors and executive officers.

Procedures for Related Party Transactions

The Separation

On April 1, 2019, we completed the Separation. The Separation was effected by means of a distribution of all of the outstanding shares of common stock of Cyclerion through a dividend in-kind of Cyclerion's common stock, with no par value, to our stockholders of record as of the close of business on March 19, 2019. In connection with the Separation, we and Cyclerion entered into certain agreements that effected the separation of Cyclerion's business from us and govern our relationship with Cyclerion after the Separation. The following is a summary of the terms of the material agreements that we have entered into with Cyclerion in connection with the Separation. Dr. Currie, our former senior vice president, chief scientific officer and president of R&D and current member of our board of directors, was president and chief scientific officer of Cyclerion in 2020 and is currently a senior advisor to Cyclerion.

Separation Agreement

In connection with the Separation, Ironwood entered into a separation agreement with Cyclerion, dated as of March 30, 2019, that, among other things, set forth our agreements with Cyclerion regarding the principal actions to be taken in connection with the Separation, including the distribution detailed above. The separation agreement identified assets to be transferred, liabilities to be assumed and contracts to be assigned to each of Ironwood and Cyclerion as part of the Separation, and it provided for when and how these transfers, assumptions and assignments would occur. The separation agreement was intended to provide for those transfers of assets and assumptions of liabilities that were necessary so that after the Separation, Ironwood and Cyclerion would have the assets necessary to operate their respective businesses and retain or assume the liabilities related to those assets. Each of Ironwood and Cyclerion agreed to releases, with respect to pre-distribution claims, and cross indemnities, with respect to post-distribution claims, that, except as otherwise provided in the separation agreement, were principally designed to place financial responsibility for the obligations and liabilities allocated to Ironwood under the separation agreement with Ironwood and financial responsibility for the obligations and liabilities allocated to Cyclerion under the separation agreement with Cyclerion.

2021  Proxy Statement    71


Table of Contents

GRAPHIC

Ironwood and Cyclerion also were each subject to two-year non-solicit and non-hire restrictions, which ended on April 1, 2021. In addition, the parties agreed to certain non-competition restrictions, including Ironwood's agreement not to engage, for three years following the Separation, in the business of discovering, researching, developing, importing, exporting, manufacturing, marketing, distributing, promoting or selling any pharmaceutical product (a) for the diagnosis, prevention or treatment of diabetic nephropathy, heart failure with preserved ejection fraction or sickle cell disease or (b) that contains one or more soluble guanylate cyclase, or sGC, stimulators.

Development Agreement

We entered into a development agreement with Cyclerion whereby Cyclerion provided us with certain research and development services with respect to certain products and product candidates, including without limitation MD-7246 (linaclotide delayed release) and IW-3718. Such research and development activities were governed by a joint steering committee comprised of representatives from both Cyclerion and Ironwood. We paid Cyclerion fees for such research and development services as mutually agreed upon by us and Cyclerion as provided under this development agreement with certain allowances for specified overages. This agreement terminated effective March 31, 2021. We incurred approximately $6.9 million under this agreement.

Transition Services Agreements

Ironwood Transition Services

Prior to the Separation, we provided Cyclerion with certain corporate and shared services and resources related to corporate functions such as finance, human resources, internal audit, research and development, financial reporting and information technology, which we refer to collectively as the "Ironwood Services." Pursuant to this agreement, each of the Ironwood Services was to continue for an initial term of up to two years (as applicable), unless earlier terminated or extended according to the terms of the transition services agreement. This agreement terminated effective March 31, 2020. We received approximately $313,428 in total fees for the Ironwood Services under this agreement, which fees were based on our cost of providing the Ironwood Services.

Cyclerion Transition Services

We also entered into a second transition services agreement whereby Cyclerion provided certain finance, procurement and facilities services to us, which we refer to herein collectively as the "Cyclerion Services." Pursuant to this agreement, each of the Cyclerion Services were available to us for a term of one year; this agreement terminated effective March 31, 2020. We paid approximately $105,060 in total fees for the Cyclerion Services under this agreement, which fees were based on Cyclerion's cost of providing the Cyclerion Services.

Intellectual Property License Agreement

We entered into an intellectual property license agreement with Cyclerion pursuant to which each party granted a license to the other party to certain know-how. We granted Cyclerion a perpetual, worldwide, non-exclusive, royalty-free, fully paid-up license to certain know-how to allow Cyclerion to use such know-how in connection with Cyclerion's ongoing and future research and development activities related to sGC stimulator products in any field. Cyclerion granted us a perpetual, worldwide, non-exclusive, royalty-free, fully paid-up license to certain know-how for use outside of the research and development of sGC stimulator products, including in our existing products and product candidates. Such licenses between the parties generally allow current or future uses of the know-how in connection with each party's respective fields.

72    Ironwood


Table of Contents

GRAPHIC

Tax Matters Agreement

We entered into a tax matters agreement with Cyclerion that governs Ironwood's and Cyclerion's respective rights, responsibilities and obligations with respect to taxes (including taxes arising in the ordinary course of business and taxes, if any, incurred as a result of any failure of the distribution of Cyclerion common stock to Ironwood stockholders and certain related transactions to qualify as tax-free for U.S. federal income tax purposes), tax attributes, the preparation and filing of tax returns, the control of audits and other tax proceedings and assistance and cooperation in respect of tax matters.

The tax matters agreement imposed certain restrictions on Cyclerion and its subsidiaries (including restrictions on share issuances, business combinations, sales of assets and similar transactions) designed to preserve the tax-free status of the distribution and certain related transactions. The tax matters agreement also provided special rules that allocate tax liabilities in the event the distribution, together with certain related transactions, is not tax-free. In general, under the tax matters agreement, each party is expected to be responsible for any taxes imposed on Ironwood or Cyclerion that arise from the failure of the distribution, together with certain related transactions, to qualify as a transaction that is generally tax-free, for U.S. federal income tax purposes, under Sections 355 and 368(a)(1)(D) and certain other relevant provisions of the Code, to the extent that the failure to so qualify is attributable to an acquisition of stock or assets of, or certain actions, omissions or failures to act of, such party. If both Cyclerion and Ironwood are responsible for such failure, liability will be shared according to relative fault. U.S. tax otherwise resulting from the failure of the distribution, together with certain related transactions, to qualify as a transaction that is tax-free generally is the responsibility of Ironwood.

Employee Matters Agreement

We entered into an employee matters agreement with Cyclerion, which allocated assets, liabilities and responsibilities relating to the employment, compensation, and employee benefits of Ironwood and Cyclerion employees, and other related matters in connection with the Separation, including the treatment of outstanding incentive equity awards and certain retirement and welfare benefit obligations. The employee matters agreement generally provided that, unless otherwise specified, Cyclerion is responsible for liabilities associated with employees who transferred to Cyclerion and employees whose employment terminated prior to the Separation but who primarily supported the Cyclerion business, whether incurred prior to or after the Separation, and Ironwood is responsible for liabilities associated with other employees, including employees retained by Ironwood.

Procedures for Related Party Transactions

Under our code of business conduct and ethics, our employees,directors, officers and directorsemployees are discouraged from entering into any transactionactivity that may create or give the appearance of a conflict of interest. In addition, they must report any potential conflict of interest, including related party transactions, to their supervisor, certain members of our management or the chair of our audit committee. Pursuant to its charter, our audit committee must review and approve anyall related party transactions including those transactions involving our directors.required to be disclosed under Item 404 of Regulation S-K under the Exchange Act. In approving or rejecting a proposed transaction, the audit committee considers the relevant facts and circumstances available to and deemed relevant by the audit committee, including the material terms of the transaction, risks, benefits, costs, availability of other comparable services or products and, if applicable, the impact on a director'sdirector’s independence. Our audit committee will approve only those transactions that, in light of known circumstances, are in, or are not inconsistent with, our best interests, as our audit committee determines in the good faith exercise of its discretion. A copy of our code of business conduct and ethics and our audit committee charter are available through the Investors section of our website at www.ironwoodpharma.com, under the heading Corporate Governance.

2021Governance — Governance Documents.


2024 Proxy Statement   73


Table of Contents

GRAPHIC


Table of Contents

GRAPHIC 77

[MISSING IMAGE: cv_ibc-4c.jpg]
PROPOSAL No. 3
Ratification of
Our Selection
of Auditors

Proposal No. 3

[MISSING IMAGE: ic_check-pn.gif]
OUR BOARD RECOMMENDS THAT YOU RATIFY THE SELECTION OF ERNST & YOUNG LLP AS OUR AUDITORS FOR FISCAL YEAR 2024

[MISSING IMAGE: ic_prop3-bw.gif]

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
Proposal No. 3
Our audit committee has appointed Ernst & Young LLP to serve as our auditors for the fiscal year ending December 31, 2021.2024. The firm of Ernst & Young LLP, an independent registered public accounting firm, has served as Ironwood'sIronwood’s auditor since 1998 and has audited our financial statements for the years ended December 31, 2020, 2019 and 2018.1998. Detailed disclosure of the audit audit-related, tax and other fees billed for services rendered by Ernst & Young LLP in 20202023 and 20192022 are set forth below. Detailed disclosure of the audit-related fees in 2023, which were billed for services rendered by VectivBio’s former auditor, Ernst & Young AG, an independent registered public accounting firm and an affiliate of Ernst & Young LLP, or collectively with Ernst & Young LLP, Ernst & Young, are set forth below. There were no tax fees billed for services rendered by Ernst & Young in 2023 or 2022 and no audit-related fees billed for services rendered by Ernst & Young in 2022. Based on these disclosures and information in the audit committee report on page 1922 of this proxy statement, our audit committee is satisfied that our auditors are sufficiently independent of management to perform their duties properly. Although not legally required to do so, our board of directors considers it desirable to seek, and recommends, stockholder ratification of its selection of auditors for fiscal year 2021.

2024.

Representatives of Ernst & Young LLP are expected to attend the virtual annual meeting to answer any questions and they will have the opportunity to make a statement if they wish.

The table below presents aggregate fees for professional audit services rendered by Ernst & Young LLP for the audits of our annual financial statements for the years ended December 31, 20202023 and 20192022 and fees billed for other services rendered by Ernst & Young LLP during those periods. It is the audit committee'scommittee’s policy that all audit and non-audit services to be performed by Ernst & Young LLP be pre-approved. The audit committee annually reviews and pre-approves the permissible services that may be provided by Ernst & Young LLP to assure the provision of such services does not impair the auditor'sauditor’s independence. In accordance with the pre-approval policy, our management informs the audit committee of each service performed by Ernst & Young LLP pursuant to the pre-approval policy. Requests to provide services that require separate approval by the audit committee are submitted to the audit committee or its designee by our chief financial officer chief accounting officer or controller and Ernst & Young LLP.Young. All of the services described in the following fee table were approved in conformity with the audit committee'scommittee’s pre-approval policy.

[MISSING IMAGE: bc_line-4c.jpg]
20232022
Audit$2,639,227$1,132,151
Audit-related$385,104$
All other$$4,615
Total$3,024,331$1,136,766

  2020  2019
 

Audit

 $1,372,342 $1,840,900 

Audit-related

 $ $ 

Tax

 $ $ 

All other

 $6,860 $1,735 

 $1,379,202 $1,842,635 

Audit fees for 2020in 2023 and 20192022 were for professional services rendered by Ernst & Young LLP for the audits of our financial statements and internal controls over financial reporting, including accounting consultations and reviews of quarterly financial statements, as well as for services that are normally providedstatements. The increase in connection with regulatory filings or engagements, including auditor consents. Additionally we incurred approximately $198,000 of audit fees relatedfor 2023 compared to 2022 pertains primarily to the Separation whichacquisition of VectivBio.

Audit-related fees in 2023 were reimbursedfor professional services rendered by Cyclerion pursuant to the Tax Matters Agreement. Audit feesErnst & Young AG for 2020 were significantly lower than they were in 2019 due to services provided in 2019audits, consents, and statutory filings in connection with the Separation, including the review and/or auditacquisition of discontinued operations, as well as accounting review of certain collaboration and co-promotion agreements and debt-related transactions.

OtherVectivBio.

All other services in 2020 and 20192022 include license fees for a web-based accounting research tool.

Other than the foregoing, Ernst & Young LLP did not provide any other services to us in 20202023 or 2019.

2022.

Vote Required

The approval of the proposal to ratify the selection of Ernst & Young LLP as our auditors requires a majority of the votes cast for or against the proposal. Because we believe this matter to be routine, a broker nominee may vote on your behalf if you do not otherwise provide instructions. As a result, we do not expect there will be any broker non-votes on this matter. Abstentions will not affect the outcome of this proposal.

2021


2024 Proxy Statement   75


Table of Contents

79

User's
[MISSING IMAGE: htr_bluegreen-4c.jpg]
User’s Guide

Our board of directors is soliciting proxies for the 20212024 annual meeting of stockholders. This proxy statement explains the agenda, voting information and procedures for the meeting. Please read it carefully. This proxy statement and related materials are first being made available to stockholders on or about April 22, 2021,25, 2024, and the notice of internet availability of proxy materials is first being sent to our stockholders on the same day. All stockholders will also have the ability to access the proxy materials online through the Investors section of our website at www.ironwoodpharma.com, under the heading Financial Information—Financials — SEC Filings.

Who can vote

Only stockholders of record of our Class A common stock at the close of business on April 12, 202119, 2024 can vote at the meeting.

Quorum

In order to hold and complete the business of the annual meeting, we must have a majority of the votes entitled to be cast represented at the meeting or by proxy. On our record date, April 12, 2021,19, 2024, we had 161,935,176158,957,123 shares of our Class A common stock outstanding and entitled to vote. With respect to all matters that will come before the meeting, each share is entitled to one vote.

Notice of internet availability of proxy materials

Pursuant to rules adopted by the SEC, we have elected to provide access to our proxy materials via the internet. Accordingly, we are sending a notice of internet availability of proxy materials to our stockholders. All stockholders will have the ability to access the proxy materials on the website referenced in the notice and to request to receive a printed set of the proxy materials by mail. Instructions on how to access the proxy materials over the internet and how to request a printed copy may be found in the notice. In addition, stockholders may request to receive proxy materials in printed form by mail or electronically by email on an ongoing basis. We encourage stockholders to take advantage of the availability of the proxy materials on the internet or through email to help reduce the environmental impact of our annual meetings.

Voting procedures—procedures — stockholders of record and beneficial owners

You are a stockholder of record if your shares of our stock are registered directly in your own name with our transfer agent, Computershare Trust Company, N.A., or Computershare. You are a beneficial owner if a brokerage firm, bank, trustee or other agent, called a "nominee,"“nominee,” holds your stock. This is often called ownership in "street name"“street name” because your name does not appear in the records of Computershare. If you hold your shares in street name, you should receive a voting instruction form from your nominee.

How to vote your shares.

If you are a stockholder of record, there are four ways to vote:


Online Before the Meeting. You may vote by proxy via the internet by following the instructions provided on the notice of internet availability of proxy materials or the proxy card. You must have the

76    Ironwood


Table of Contents

GRAPHIC

      16-digit control number that is on either the notice of internet availability of proxy materials or the proxy card when voting.


Online During the Meeting. You may vote online during the annual meeting through the link www.virtualshareholdermeeting.com/IRWD2021. The 16-digit control number provided on your notice of internet availability of proxy materials or proxy card is necessary to

80   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
access the website. The meeting will begin at 9:00 a.m. Eastern Time (with log-in beginning at 8:45 a.m. Eastern Time) on Wednesday,Tuesday, June 2, 2021.

18, 2024.

By Telephone. If you request printed copies of the proxy materials by mail and you live in the United States or Canada, you may vote by proxy by calling the toll-free number found on the proxy card. You must have the control number that is on the proxy card when voting.


By Mail. If you request printed copies of the proxy materials by mail, you may vote by proxy by filling out the proxy card and sending it back in the envelope provided.

If you are a beneficial owner of shares held in street name, there are four ways to provide voting instructions:


Online Before the Meeting. You may provide voting instructions via the internet by following the instructions provided on your voting instruction form. You must have the 16-digit control number that is on the voting instruction form when voting.


Online During the Meeting. You may vote online during the annual meeting through the link www.virtualshareholdermeeting.com/IRWD2021.IRWD2024. The 16-digit control number provided on your voting instruction form is necessary to access the website. The meeting will begin at 9:00 a.m. Eastern Time (with log-in beginning at 8:45 a.m. Eastern Time) on Wednesday,Tuesday, June 2, 2021.

18, 2024.

By Telephone. You may provide voting instructions by calling the toll-free number found on your voting instruction form. You must have the control number that is on the voting instruction form when voting.


By Mail. You may provide voting instructions by filling out the voting instruction form and sending it back in the envelope provided.

How you may revoke your proxy or voting instructions. If you are a stockholder of record, you may revoke or amend your proxy before it is voted at the annual meeting by writing to us directly in a timely manner "revoking"“revoking” your earlier proxy, submitting a new proxy in a timely manner with a later date by mail, over the telephone or on the internet, or by attending the meeting and voting. Your last dated proxy timely received prior to or vote cast at the annual meeting will be counted.

What if you receive more than one notice of internet availability of proxy materials, proxy card or voting instruction form? This means that you may have more than one account at Computershare and/or with a nominee. Your notice of internet availability of proxy materials, proxy card or voting instruction form lists the number of shares you are voting. Please vote the shares on all notices of internet availability of proxy materials, proxy cards and voting instruction forms that you receive.

We recommend you consolidate your holdings under the same name, address and tax identification number, if possible. This will eliminate some duplication of mailings and reduce costs. Please contact your nominee to consolidate accounts, or our transfer agent, Computershare, at (800) 368-5948, as applicable.

Householding of proxy materials. SEC rules concerning the delivery of proxy materials allow us or your broker to send a single notice or, if applicable, a single set of our proxy materials to any household at which two or more of our stockholders reside, if we or your broker believe that the stockholders are members of the same family, unless we have received contrary instructions from one or more of the stockholders. This practice, referred to as "householding,"“householding,” benefits both you and us. It reduces the volume of duplicate information received at your

2021  Proxy Statement    77


Table of Contents

GRAPHIC

household and helps to reduce our expenses. The rule applies to our notices, annual reports, proxy statements and information statements.

We will undertake to deliver promptly, upon written request, a separate copy to a stockholder at a shared address to which a single copy of the notice of internet availability of proxy materials was delivered. You may make a written request by sending a notification to our Secretary at the address below, providing your name, your shared address, and the address to which we should direct the additional copy of the notice of internet availability of proxy materials. Multiple stockholders sharing an address who have received one copy of a mailing and would prefer us to mail each stockholder a separate copy of future mailings should contact us at the below address, as well. Additionally, if current stockholders with a shared address received multiple copies of a mailing and would prefer us to mail one copy of future mailings

2024 Proxy Statement   81

[MISSING IMAGE: hr_greenltsm-4c.jpg]
to stockholders at the shared address, notification of that request may also be sent to us at the below address. Stockholders who participate in householding will continue to have access to and utilize separate proxy voting instructions.

Any request relating to receipt of proxy materials should be sent to: Secretary, Ironwood Pharmaceuticals, Inc., 100 Summer Street, Suite 2300, Boston, Massachusetts 02110.

Abstentions and "broker“broker non-votes." If you are a stockholder of record and you vote "abstain"“abstain” or "withhold"“withhold” on any matter, your shares will not be voted on that matter and will not be counted as votes cast in the final tally of votes on that matter. However, your shares will be counted for purposes of determining whether a quorum is present. If you are a beneficial owner holding shares through a broker nominee, you may instruct your broker nominee that you wish to abstain from voting on a proposal or withhold authority to vote for one or more nominees for director.

A broker nominee generally may not vote on "non-routine"“non-routine” matters without receiving your specific voting instructions. A "broker non-vote"“broker non-vote” occurs when a broker nominee holding shares in street name votes shares on some matters at the meeting but not others. Like abstentions, broker non-votes are counted as present and entitled to vote for quorum purposes, but are not counted as votes cast. Broker nominees who hold shares for the accounts of their clients have discretionary authority to vote shares if specific instructions are not given with respect to routine matters. Although the determination of whether a broker nominee will have discretionary voting power for a particular item is typically determined only after proxy materials are filed with the SEC, we expect that at the annual meeting of stockholders your broker nominee will not be able to submit a vote on the election of directors or the advisory votes on named executive officer compensation unless it receives your specific instructions, but will be able to vote on the ratification of the selection of our independent auditors even if it does not receive your instructions. As a result, if your broker nominee does not receive your specific instructions for these proposals, it will submit a broker non-vote on the election of directors or the advisory votes on named executive officer compensation andnon-vote. The broker nominee may, however, vote on the ratification of the selection of our independent auditors even if it does not receive your instructions.

Discretionary authority. If you are a stockholder of record and you properly submit your proxy card without making any specific selections, your shares will be voted on each matter before the annual meeting in the manner recommended by our board of directors. If other matters not included in this proxy statement properly come before the annual meeting, the persons named on the proxy card, or otherwise designated, will have the authority to vote on those matters for you as they determine, to the extent permitted by Rule 14a-4(c)(1) of the Exchange Act. If you are a beneficial owner of shares held in street name, please see the discussion above regarding broker non-votes and the rules related to voting by broker nominees.

Vote required

The required vote for each of the proposals expected to be acted upon at the annual meeting is described below.

78    Ironwood


Table of Contents

GRAPHIC

Proposal No. 1—1 — Election of Class I and Class II Directors:

The sevenboard of director nominees forwill be determined by a plurality of the votes cast, meaning that board of director nominees with the highestgreatest number of affirmative votes cast for election, even if less than a majority, will be elected as directors to serve for one-year terms and until their successors arehis or her successor is duly elected and qualified or until their death, resignation or removal. We expect that broker nominees will not have discretion to vote on this proposal without your instruction; if you do not instruct your broker nominee how to vote on this proposal, your broker nominee will deliver a broker non-vote.non- vote. Because there is no minimum vote required, abstentions and broker non-votes will not affect the outcome of this proposal.

Proposal No. 2—2 — Advisory (non-binding) Vote on Named Executive Officer Compensation, or "Say-on-Pay"“Say-on-Pay”:
Because this proposal calls for a non-binding, advisory vote there is no "required vote"“required vote” that would constitute approval. However, our board of directors, including our compensation and HR committee, values the opinions of our stockholders and, to the extent there are a substantial number of votes cast against the named executive officer compensation disclosed in this proxy statement, we will consider our stockholders'stockholders’ concerns and evaluate what actions may be appropriate to address those concerns. We expect that broker nominees will not have discretion to vote on

82   Ironwood

[MISSING IMAGE: htr_greenorangebanner-4c.jpg]
this proposal without your instruction; if you do not instruct your broker nominee how to vote on this proposal, your broker nominee will deliver a broker non-vote. Any shares that are not voted, whether by abstention, broker non-votes or otherwise, will not affect the outcome of this proposal.

Proposal No. 3—3 — Ratification of Auditors:
The approval of this proposal requires a majority of the votes cast for or against the proposal. Abstentions and broker non-votes will not affect the outcome of this proposal. Further, because we believe this matter to be routine, a broker nominee may vote on your behalf if you do not otherwise provide instructions. As a result, we do not expect there will be any broker non-votes on this matter.

Results of the voting. We expect to announce the preliminary voting results at the annual meeting. The final voting results will be tallied by the inspector of election and published in a Current Report on Form 8-K, which we are required to file with the SEC, within four business days following the annual meeting.

Costs of solicitation and solicitation participants. We will pay the costs of soliciting proxies. These costs also include support for the hosting of the virtual meeting. We will solicit proxies by email from stockholders who are our employees or who previously requested to receive proxy materials electronically. Our directors, our officers and our employees also may solicit proxies on our behalf, personally, electronically or by telephone, facsimile or mail or other means, without additional compensation. We may request that brokerage firms, banks and other agents forward proxy materials to beneficial owners and we would reimburse such institutions for their out-of-pocket expenses incurred.

We may also utilize the assistance of third parties in connection with our proxy solicitation efforts and we would compensate such third parties for their efforts. We have engaged one such third party, MacKenzie Partners, to assist in the solicitation of proxies and provide related advice and informational support, for service fees of up to $12,500 and the reimbursement of certain expenses.

Additional Meeting Information

We encourage you to access the meeting prior to the start time. Please allow sufficient time for online log-in, which begins at 8:45 a.m. Eastern Time. You may check your browser'sbrowser’s compatibility any time prior to the meeting at www.virtualshareholdermeeting.com/IRWD2021IRWD2024. If you want to submit a question you may do so electronically starting at the time of check-in or during the meeting.

If you have technical difficulties or trouble accessing the virtual meeting, there will be technicians ready to assist you. If you encounter any technical difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the virtual stockholder meeting log in page.

2021


2024 Proxy Statement   79


Table of Contents

83

[MISSING IMAGE: htr_bluegreen-4c.jpg]
Stockholder Communications, Proposals
and Nominations for Directorships

Communications

A stockholder may send general communications to our board of directors, any committee of our board of directors or any individual director by directing such communication to Secretary, Ironwood Pharmaceuticals, Inc., 100 Summer Street, Suite 2300, Boston, Massachusetts 02110. All communications will be reviewed by our Secretary and, if requested by the stockholder, forwarded to our board of directors or an individual director, as applicable. Our Secretary reserves the right not to forward to our board of directors or any individual director any abusive, threatening or otherwise inappropriate materials.

Any request for materials or other communications directed to our secretary should be sent to: Secretary, Ironwood Pharmaceuticals, Inc., 100 Summer Street, Suite 2300, Boston, Massachusetts 02110.

Proposals and Nominations

Proposals and Nominations

Stockholders who wish to present a proposal for inclusion in our proxy materials for our 20222025 annual meeting should follow the procedures prescribed in Rule 14a-8 under the Exchange Act and our bylaws. Those procedures require that we receive a stockholder proposal in writing no later than December 23, 202126, 2024 in order for such proposal to be included in our proxy materials.

Under our bylaws, stockholders who wish to nominate a director or include a proposal in our 20222025 annual meeting of stockholders (but do not wish to include such proposal in our proxy materials) must give us timely notice. To be timely, a notice of director nomination or other proposal for the 20222025 annual meeting of stockholders must be received by us no earlier than March 4, 202220, 2025 and no later than April 3, 2022,19, 2025, unless the date of the 20222025 annual meeting of stockholders is more than 30 days from the anniversary date of the 20212024 annual meeting of stockholders, in which event the notice must be received by us on or before 15 days after the day on which the date of the 20222025 annual meeting of stockholders is first disclosed in a public announcement. The notice must contain specified information that is prescribed in our bylaws about you and the director nominee or the proposal, as applicable. If any director nomination or stockholder proposal is submitted after April 3, 2022,19, 2025, our bylaws provide that the nomination or the proposal shall be disregarded.

80    Ironwood


Table Any stockholder who intends to solicit proxies in support of Contents

a director nominee other than the company’s nominees must also comply with Rule 14a-19 under the Exchange Act.
GRAPHIC
84   Ironwood

We file annual, quarterly and current reports, as well as other information with the SEC. You can obtain any of them from the SEC at its website at www.sec.gov. The documents are also available from us without charge by requesting them in writing or by telephone from Ironwood Pharmaceuticals, Inc., 100 Summer Street, Suite 2300, Boston, Massachusetts 02110, Attention: Corporate Communications, telephone: (617) 621-7722, or by visiting the Investors section of our website at www.ironwoodpharma.com.

2021


2024 Proxy Statement   81


GRAPHIC


GRAPHIC


85

[MISSING IMAGE: px_24ironwoodproxy01pg01-bw.jpg]
RONWOOD PHARMACEUTICALS, INC.100 SUMMER STREET, SUITE 2300BOSTON, MA 02110SCAN TOVIEW MATERIALS & VOTEVOTE BY INTERNET BeforeINTERNETBefore The Meeting - Go to www.proxyvote.com Youor scan the QR Barcode aboveYou may use the Internet to transmit your voting instructions and for electronic deliveryelectronicdelivery of information up until 11:59 P.M. Eastern Time the day before the meeting date. Have youron June 17, 2024. Haveyour proxy card in hand when you access the web site and follow the instructions toinstructionsto obtain your records and to create an electronic voting instruction form. IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON, MA 02110 Duringform.During The Meeting - Go to www.virtualshareholdermeeting.com/IRWD2021 YouIRWD2024You may also vote during the meeting. Have the information that is printed in theinthe box marked by the arrow available and follow the instructions. ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALS If you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years. VOTEinstructions.VOTE BY PHONE - 1-800-690-6903 Use1-800-690-6903Use any touch-tone telephone to transmit your voting instructions up until 11:until11:59 P.M. Eastern Time the day before the meeting date.on June 17, 2024. Have your proxy card in hand when youwhenyou call and then follow the instructions. VOTEinstructions.VOTE BY MAIL Mark,MAILMark, sign and date your proxy card and return it in the postage-paid envelopepostage-paidenvelope we have provided or return it to Vote Processing, c/o Broadridge, 51Broadridge,51 Mercedes Way, Edgewood, NY 11717. TO11717.TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: D43110-P53341 KEEP THIS PORTION FOR YOUR RECORDS DETACH AND RETURN THIS PORTION ONLY THISRECORDSTHIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. DETACH AND RETURN THIS PORTION ONLYV42104-P05088 IRONWOOD PHARMACEUTICALS, INC. TheINC.The Board of Directors recommends you vote FOR theALLthe following: For Withhold For All AllAllExcept To withhold authority to vote for any individual nominee(s), mark "For All Except" and write the number(s) of the nominee(s) on the line below. ! !! 1. Election of Directors Nominees: Class I 01) 02) 03) Mark G. Currie, Ph.D. Alexander J. Denner, Ph.D. Jon R. Duane Class II 04) 05) 06) 07) Marla L. Kessler Catherine Moukheibir Lawrence S. Olanoff, M.D., Ph.D. Jay P. Shepard For Against Abstain The Board of Directors recommends you vote FOR the following proposals: ! ! ! ! ! ! 2. Approval, by non-binding advisory vote, of the compensation paid to the named executive officers. 3. Ratification of the selection of Ernst & Young LLP as the Company's independent registered public accounting firm for 2021. NOTE: In their discretion, the Proxies are authorized to vote upon such other business as may properly come before the meeting or any adjournment or postponement thereof. Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint ownersJointowners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signatureofficer.1. Election of Directors. To elect nine director nomineesnumbered 01 through 09 to serve for a one-year termextending until the 2025 annual meeting of stockholdersand their successors are duly elected and qualified. ForAllWithholdAllFor AllExceptTo withhold authority to vote for any individualnominee(s), mark "For All Except" and write thenumber(s) of the nominee(s) on the line below.Nominees:01) Mark Currie, Ph.D.02) Alexander Denner, Ph.D.03) Andrew Dreyfus04) Jon Duane05) Marla Kessler06) Thomas McCourt07) Julie McHugh08) Catherine Moukheibir09) Jay ShepardThe Board of Directors recommends you vote FOR the following proposals:For Against Abstain2. Approval, by non-binding advisory vote, of the compensation paid to the named executive officers.! ! !3. Ratification of the selection of Ernst & Young LLP as Ironwood Pharmaceuticals, Inc.'s independent registered public accounting firm for 2024.! ! !NOTE: In their discretion, the proxies are authorized to vote upon such other business as may properly come before the meeting or any adjournment orpostponement thereof.Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Jointowners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer.Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date


[MISSING IMAGE: px_24ironwoodproxy01pg02-bw.jpg]

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:The Notice, Proxy Statement and Annual Report on Form 10-K are available at www.proxyvote.com. D43111-P53341 IRONWOOD PHARMACEUTICALS, INC. Annual Meeting of Stockholders Wednesday, June 2, 2021 9:00 AM Eastern Time This proxy is solicited by the Board of Directors Thewww.proxyvote.com.V42105-P05088The stockholder(s) hereby appoint(s) Thomas McCourt and Gina Consylman,Sravan Emany, or either of them, as proxies, each with the power to appoint his or her substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of common stockClass A Common Stock of IRONWOOD PHARMACEUTICALS, INC. that the stockholder(s) is/are entitled to vote at the Annual Meeting of Stockholders to be held at 9:00 AM,a.m., Eastern Time on Wednesday,Tuesday, June 2, 202118, 2024 via live webcast at www.virtualshareholdermeeting.com/IRWD2021,atwww.virtualshareholdermeeting.com/IRWD2024, and any adjournment or postponement thereof. The stockholder(s) hereby revoke(s) any proxy previously given and acknowledge(s) receipt of the notice and proxy statement for the Annual Meeting of Stockholders. This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the recommendations of the Board of Directors. ContinuedIRONWOOD PHARMACEUTICALS, INC.Annual Meeting of StockholdersTuesday, June 18, 2024 9:00 a.m. Eastern TimeThis proxy is solicited by the Board of DirectorsContinued and to be signed on reverse side



0001446847 4 2023-01-01 2023-12-31